Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

by Pivonka, Don E.; Chalmers, John M.; Griffiths, Peter R.

• ISBN13: 9780470870877
• ISBN10: 0470870877
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-05-07
• Publisher: Wiley-Interscience
• More Book Details

Summary

Although vibrational spectroscopy is a critical technology within the pharmaceutical industry, currently the literature regarding its applications in the field is fragmented. At present there is no single volume that brings together the diverse aspects of vibrational spectroscopy at a level that will provide value to the dedicated spectroscopist as well as to the synthetic, development and medicinal based chemists, alike. This volume aims to present key themes, established and emerging, within current research as well as presenting detailed contributions on the instrumentation, methodology, data treatment, and applications associated within this area of research. It will provide a consolidated "road map" to the practice of this science within the industry.

Author Biography

Dr Don Pivonka, Principal Chemist I, AstraZeneca Pharmaceuticals, Wilmington, USA.

Professor P.R. Giffiths, University of Idaho, USA.

Mr J.M. Chalmers, Nottingham University, UK.

Table of Contents

Introduction

Introduction to Vibrational Spectroscopy

Part 2

Sampling Techniques and Fiber-Optic Probes

Vibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research

Applications of Vibrational Spectroscopy to Combinatorial Chemistry

Vibrational Spectroscopic Analysis for the Determination of Structure-Activity Relationships (SARs) in Molecular Binding

Applications of Vibrational Optical Activity in the Pharmaceutical Industry

Characterization and Optimization of Chemical Synthesis Using Real-Time Vibrational Spectroscopy

Part 3

Infrared and Raman Spectroscopy for Process Development

The Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy

Raman Analysis of Pharmaceuticals

Vibrational Spectroscopy of Solid-State Forms - Introduction, Principles and Overview

Vibrational Spectroscopy of Solid-State Forms - Applications and Examples

Pharmaceutical Applications of Chemical Mapping and Imaging

Terahertz Spectroscopy for Pharmaceutical Applications

Part 4

History, Trends and Prognostications

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