Applied Antisense Oligonucleotide Technology

by Stein, Cy A.; Krieg, Arthur M.

• ISBN13: 9780471172796
• ISBN10: 0471172790
• Edition: 1st
• Format: Paperback
• Copyright: 1998-03-19
• Publisher: Wiley-Liss

Summary

Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression. Chapters include oligonucleotide chemistry, DNA triplex formation, delivery mechanisms, pharmocokinetics, toxicity, oligonucleotides.

Author Biography

Cy A. Stein is the editor of Applied Antisense Oligonucleotide Technology, published by Wiley. Arthur M. Krieg is the editor of Applied Antisense Oligonucleotide Technology, published by Wiley.

Table of Contents

PREFACE	ix	(1)
CONTRIBUTORS	x
I CHEMISTRY, OLD AND NEW	1	(108)
1 OLIGONUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND PROPERTIES	3	(20)
Paul S. Miller
2 OLIGO(NUCLEOSIDE PHOSPHOROTHIOATE)S	23	(28)
Piotr Guga
Maria Koziolkiewicz
Andrzej Okruszek
Wojciech J. Stec
3 MODIFIED OLIGODEOXYNUCLEOTIDES AS ANTISENSE THERAPEUTICS	51	(22)
Peter H. Seeberger
Marvin H. Caruthers
4 NOVEL CHEMISTRY	73	(36)
Karl-Heinz Altmann
Bernard Cuenoud
Peter Von Matt
II OLIGONUCLEOTIDE INTERNALIZATION, MECHANISM OF ACTION, AND NON-SEQUENCE SPECIFICITY	109	(64)
5 CELLULAR UPTAKE AND BIODISTRIBUTION OF OLIGODEOXYNUCLEOTIDES	111	(18)
Basil Hanss
C.A. Stein
Paul E. Klotman
6 USE OF CATIONIC LIPID COMPLEXES FOR ANTISENSE OLIGONUCLEOTIDE DELIVERY	129	(18)
C. Frank Bennett
7 NONANTISENSE EFFECTS OF ANTISENSE OLIGONUCLEOTIDES	147	(14)
Leonard M. Neckers
Kanak Iyer
8 RIBONUCLEASE H-MEDIATED ANTISENSE EFFECTS OF OLIGONUCLEOTIDES AND CONTROLS FOR ANTISENSE EXPERIMENTS	161	(12)
David M. Tidd
III.A SEQUENCE-SPECIFIC INHIBITION OF GENE EXPRESSION	173	(124)
9 THE DEVELOPMENT OF C-5 PROPYNE OLIGONUCLEOTIDES AS INHIBITORS OF GENE FUNCTION	175	(18)
W. Michael Flanagan
Richard W. Wagner
10 THE USE OF ANTISENSE OLIGONUCLEOTIDES TO INHIBIT EXPRESSION OF ISOZYMES OF PROTEIN KINASE C	193	(14)
Nicholas M. Dean
Lemonidis, K.
McKay, R.
Miraglia, L.
Trent, K.
Pribble, J.P.
11 BCR-ABL AS A TARGET FOR ANTISENSE INTERVENTION	207	(24)
Stephen G. O'Brien
Toon F.C.M. Smetsers
12 THE NF-kB TRANSCRIPTION FACTOR	231	(14)
Ramaswamy Narayanan
13 DISRUPTION OF THE MAP KINASE SIGNALING PATHWAY USING ANTISENSE OLIGONUCLEOTIDE INHIBITORS TARGETED TO RAS AND RAF KINASE	245	(18)
Brett P. Monia
14 PROTEIN KINASE A-DIRECTED ANTISENSE BLOCKADE OF CANCER GROWTH: SINGLE GENE-BASED THERAPEUTIC APPROACH	263	(20)
Yoon S. Cho-Chung
15 USE OF ANTISENSE OLIGONUCLEOTIDES IN THE CENTRAL NERVOUS SYSTEM: WHY SUCH SUCCESS?	283	(14)
Margaret M. McCarthy
III.B APPLIED ANTISENSE OLIGONUCLEOTIDE THERAPEUTICS	297	(56)
16 PERTURBING HEMATOPOIETIC CELL GENE EXPRESSION WITH OLIGODEOXYNUCLEOTIDES: RESEARCH AND CLINICAL APPLICATIONS	299	(18)
Alan M. Gewirtz
Mariusz Z. Ratajczak
17 BCL2	317	(18)
Burkhard Jansen
Bob D. Brown
18 BIOLOGICAL ACTIVITY OF GUANOSINE QUARTET-FORMING OLIGONUCLEOTIDES	335	(18)
Robert F. Rando
Michael E. Hogan
IV OLIGONUCLEOTIDES AS ANTI-HIV AGENTS	353	(42)
19 PERSPECTIVES ON ANTISENSE TECHNOLOGY AGAINST HIV	355	(10)
Jay E. Gee
Amelie Benoit de Coignac
Ian Robbins
Bernard LeBleu
20 IN VIVO PHARMACOKINETICS OF OLIGONUCLEOTIDES	365	(22)
Sudhir Agrawal
21 EARLY CLINICAL TRIALS WITH GEM 91, A SYSTEMIC OLIGODEOXYNUCLEOTIDE	387	(8)
R. Russell Martin
V THERAPEUTIC OLIGONUCLEOTIDE DATA BASE: PHARMACOKINETICS, IMMUNE STIMULATION, AND USE AS ANTIRESTENOTIC AGENTS	395	(54)
22 ANTISENSE THERAPY TO INHIBIT ANGIOPLASTY RESTENOSIS	397	(10)
Leroy E. Rabbani
Weizheng Wang
23 PHARMACOKINETICS OF OLIGONUCLEOTIDES: A REVIEW OF CURRENT KNOWLEDGE AND ISSUES FOR THE FUTURE	407	(24)
Thomas L. Wallace
Paul A. Cossum
24 LEUKOCYTE STIMULATION BY OLIGODEOXYNUCLEOTIDES	431	(18)
Arthur M. Krieg
VI SELECTED OLIGODEOXYNUCLEOTIDE DEVELOPMENTAL TOPICS: SPLICING AND TRIPLEXES	449	(60)
25 MODIFICATION OF ALTERNATIVE SPLICING OF PRE-mRNA BY ANTISENSE OLIGONUCLEOTIDES	451	(20)
Ryszard Kole
26 GENE-TARGETED TRIPLE-HELIX-FORMING OLIGONUCLEOTIDES	471	(16)
Fedor Svinarchuk
Claude Malvy
27 TRIPLEX-FORMING OLIGONUCLEOTIDES FOR GENETIC MANIPULATION: AN ALTERNATIVE VIEW	487	(22)
A. Fawad Faruqi
Peter M. Glazer
VII A REVIEW OF RIBOZYME TECHNOLOGY	509	(18)
28 THERAPEUTIC RIBOZYMES: PRINCIPLES, APPLICATIONS, AND PROBLEMS	511	(16)
John J. Rossi
INDEX	527