Applied Pharmacokinetics and Pharmacodynamics Principles of Therapeutic Drug Monitoring

by Burton, Michael E.; Shaw, Leslie M.; Schentag, Jerome J.; Evans, William E.

• ISBN13: 9780781744317
• ISBN10: 0781744318
• Edition: 4th
• Format: Paperback
• Copyright: 2005-05-19
• Publisher: LWW

Summary

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Table of Contents

Dedication and Acknowledgment	v
Preface	vii
Contributing Authors	ix
Editorial Review Board	xiii
PART I: BASIC CONCEPTS AND PRINCIPLES	1	(256)
General Principles of Clinical Pharmacokinetics	3	(5)
William E. Evans
Guidelines for Collection and Analysis of Pharmacokinetic Data	8	(22)
William J. Jusko
Critical Evaluation of Methods for Therapeutic Drug Monitoring	30	(10)
Victor W. Armstrong
Michael Oellerich
Analysis of Pharmacokinetic Data for Individualizing Drug Dosage Regimens	40	(20)
John H. Rodman
David Z. D'Argenio
Carl C. Peck
Pharmacodynamics	60	(22)
Richard L. Lalonde
Influence of Protein Binding and Use of Unbound (Free) Drug Concentrations	82	(39)
Janis J. MacKichan
Drug Metabolism, Transport, and the Influence of Hepatic Disease	121	(44)
Angela D.M. Kashuba
Joohyun J. Park
Adam M. Persky
Kim L.R. Brouwer
Application of Pharmacogenetic Principles to Clinical Pharmacology	165	(22)
Mark W. Linder
William E. Evans
Howard L. McLeod
Influence of Renal Function and Dialysis on Drug Disposition	187	(26)
Gary R. Matzke
Thomas J. Comstock
Special Pharmacokinetic and Pharmacodynamic Considerations in Children	213	(18)
Holly D. Maples
Laura P. James
Cindy D. Stowe
Special Pharmacokinetic Considerations in the Obese	231	(11)
Robert A. Blouin
Mary H.H. Ensom
Dietary Influences on Drug Disposition	242	(15)
Mary H.H. Ensom
Robert A. Blouin
PART II: MONITORED DRUGS	257	(582)
Asthma Management	259	(26)
Glenn J. Whelan
Stanley J. Szefler
Aminoglycosides	285	(43)
Jerome J. Schentag
Alison K. Meagher
Roger W. Jelliffe
Vancomycin	328	(13)
Pamela A. Moise-Broder
Microbiologic, Clinical, and Economic Outcomes of Dual Individualized Dosing of Antimicrobial Agents	341	(13)
Joseph A. Paladino
Jerome J. Schentag
Antivirals for HIV	354	(56)
Craig R. Rayner
Michael J. Dooley
Roger L. Nation
Digoxin	410	(30)
Jerome J. Schentag
Anthony J. Bang
Jennifer L. Kozinski-Tober
Clinical Pharmacokinetics of Oral Antiarrhythmic Drugs	440	(23)
Jerry L. Bauman
Harumi Takahashi
James H. Fischer
Phenytoin	463	(28)
Michael E. Winter
Thomas N. Tozer
Antiepileptic Drugs	491	(21)
William R. Garnett
Gail D. Anderson
Rebeccah J. Collins
Cyclosporine	512	(17)
Atholl Johnston
David W. Holt
Tacrolimus	529	(34)
Uwe Christians
Taveesak Pokaiyavanichkul
Laurence Chan
Mycophenolic Acid	563	(32)
Arthur Nawrocki
Magdalena Korecka
Sandra Solari
Juseop Kang
Leslie M. Shaw
Sirolimus	595	(22)
Barry D. Kahan
Kimberly L. Napoli
Anticancer Agents	617	(20)
William P. Petros
William E. Evans
Heparin --- UFH and LMWH	637	(78)
Keith A. Rodvold
Sharon M. Erdman
Kelly A. Sprandel
Robert J. Cipolle
Eleanor S. Pollak
Warfarin	715	(37)
Stuart T. Haines
Thomas Dowling
R. Donald Harvey, III
Nonsteroidal Anti-Inflammatory Drugs and Coxibs	752	(29)
Tilo Grosser
Cyclic Antidepressants	781	(17)
C. Lindsay DeVane
Lithium	798	(15)
Tawny L. Bettinger
M. Lynn Crismon
Antipsychotics	813	(26)
James M. Perel
Michael W. Jann
Appendix: A Critical Assessment of the Outcomes of Therapeutic Drug Monitoring	839	(10)
Mary H.H. Ensom
Michael E. Burton
Index	849