Aquaporins

by Beitz, Eric; Agre, P. (CON); Atkinson, J. C. (CON); Becker, D. (CON); Beitz, E. (CON)

• ISBN13: 9783540798842
• ISBN10: 3540798846
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-05-30
• Publisher: Springer Verlag

Summary

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.

Table of Contents

Introduction	p. 1
Discovery of the Aquaporins and Development of the Field	p. 3
Aquaporin Protein Structure and Selectivity Mechanisms
The AQP Structure and Functional Implications	p. 31
Dynamics and Energetics of Permeation Through Aquaporins. What do we Learn from Molecular Dynamics Simulations?	p. 57
In Vitro Analysis and Modification of Aquaporin Pore Selectivity	p. 77
Aquaporin Function in Mammalian Water Homeostasis
Aquaporins in the Kidney	p. 95
Regulation of Aquaporin-2 Trafficking	p. 133
Role of Aquaporin-4 in Cerebral Edema and Stroke	p. 159
Aquaporins as Potential Drug Targets for Meniere's Disease and its Related Diseases	p. 171
Aquaporins in Secretory Glands and their Role in Sjögren's Syndrome	p. 185
Aquaporin Glycerol Permeability in Mammalian Physiology
Skin Aquaporins: Function in Hydration, Wound Healing, and Skin Epidermis Homeostasis	p. 205
Function of Aquaporin-7 in the Kidney and the Male Reproductive System	p. 219
Role of Aquaporin-7 and Aquaporin-9 in Glycerol Metabolism; Involvement in Obesity	p. 233
New Members of Mammalian Aquaporians: AQP10-AQP12	p. 251
Aquaporin Functions Apart from Water and Glycerol Transport
Structural Function of MIP/Aquaporin 0 in the Eye Lens; Genetic Defects Lead to Congenital Inherited Cataracts	p. 265
pH Regulated Anion Permeability of Aquaporin-6	p. 299
Aquaglyceroporins and Metalloid Transport: Implications in Human Diseases	p. 309
Ammonia and Urea Permeability of Mammalian Aquaporins	p. 327
Knock-Out Models Reveal New Aquaporin Functions	p. 359
Towards Therapeutic Use of Aquaporins
Design, Synthesis and Assaying of Potential Aquaporin Inhibitors	p. 385
Aquaporin-1 Gene Transfer to Correct Radiation-Induced Salivary Hypofunction	p. 403
Index	p. 419
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