Artificial Self-Assembling Systems for Gene Delivery

by Felgner, Philip L.; Heller, Michael J.; Lehn, Pierre; Behr, Jean-Paul; Szoka, Francis C.

• ISBN13: 9780841234154
• ISBN10: 0841234159
• Format: Hardcover
• Copyright: 1996-05-05
• Publisher: American Chemical Society

Summary

Discusses recent advances in artificial self-assembling systems, including retrotransposon vectors, hairpin ribozymes, triple-helix-forming oligonucleotides, liposome-mediated transfection, and photonic nanostructures. Addresses developing efficient synthetic vectors such as modular self-assembling systems mimicking important features of viral vectors. Presents new developments in synthetic self-assembling gene delivery systems, including innovations in nonviral systems, targeting nucleic acids, ligand-polylysine mediated transfer, dendrimer-mediated transfection, cationic liposomes, and polylysine DNA complexes.

Table of Contents

Synthetic Retrotransposon Vectors and Gene Targeting

A New Retroviral Vector and a New Method To Target Homologous Recombination in Mammalian Cells

Development of the Hairpin Ribozyme as aGene Therapy Approach to Human Immunodeficiency Virus Type-1 Infection

Replicating Plasmid Vectors for Cancer Gene Therapy

Gene Targeting Using Triple-Helix-Forming Oligonucleotides

Effects of Lipololysaccahrideson Liposome-Mediated Transfection and the Consequence for DNA Preparation for Gene Therapy

The Application of Electronic Pulse Delivery in Gene Therapy

Progressand Perspectives

Self-Assembling DNA Photonic Nanostructures

Controllable Gene Therapy Using Nonviral Systems

Progress in Targeting Nucleic Acids to the Liver

Advances in Receptor-Mediated Gene Transfer into Cells In Vitro and In Vivo

Ligand-Polylysine Mediated Gene Transfer

Efficient Transfer of Genetic Material into Mammalian Cells Using Polyamidoamine Dendrimers as Synthetic Vectors

Dendrimer-Mediated Transfection

The Proton Sponge

A Trick the Viruses Did Not Exploit

Biomaterials for Gene Transfer

Self-Assembling Nanostructured Aquasomes

Gene Transfer by Liposome-Entrapped Polycation-Condensed DNA

LPDI and LPDIIR

Gene Transfer into Mammalian Cells Using Synthetic Cationic Lipids

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