Ashgate Handbook of Autonomic Nervous System Agents

by Milne, G. W. A.

• ISBN13: 9780566083846
• ISBN10: 0566083841
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-01-01
• Publisher: WILEY

Summary

The Autonomic Nervous System (ANS) supplies all innervated structures of the body other than skeletal muscle, and its effects are therefore pervasive. The range of available ANS-active compounds can effectively modulate any or all body systems. The ANS-active agents include drugs used to treat a wide spectrum of conditions including hypertension, myocardial insufficiency, migraine, nasal congestion, obesity, Parkinson's disease, and glaucoma. Drugs from an array of therapeutic categories, including vasodilators, muscle relaxants, gastroprokinetics, and bronchodilators, can be classified as ANS agents.ThisHandbook contains records for all the major drugs that mimic or block the actions of ANS neurotransmitters or whose activities involve a direct effect on ANS neurotransmitter production, destruction or reuptake, or on junctional transmission. Monographs are provided for 1,996 ANS agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and theMerck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

Author Biography

G.W.A Milne was a Senior Researcher at the National Institutes of Health in Bethesda, MD, USA for 35 years where he worked on the use of spectroscopy for structure determination of organic compounds, and on molecular modeling in the design of drugs for the treatment of cancer and AIDS. He has been active for many years in the fields of chemical information and chemical computation and is the Editor of the American Chemical Society’s Journal of Chemical Information and Computer Science; Gardner’s Chemical Synonyms and Trade Names, Eleventh Edition (Ashgate); and Drugs: Synonyms and Properties (Ashgate).

Table of Contents

Preface	vii
Acknowledgements	ix
How to Use This Book	xi
Glossary of Units	xv
Abbreviations and Symbols	xvii
PART I MAIN ENTRIES	1	(322)
Adrenergic Antagonists	3	(113)
alpha-Adrenergic Blockers	3	(8)
beta-Adrenergic Blockers	11	(19)
Antianginals	30	(12)
Antiarrhythmics	42	(14)
Anti-BPH Agents	56	(2)
Antiglaucoma Agents	58	(8)
Antihypertensives	66	(32)
Antimigraines	98	(2)
Antipheochromocytoma Agents	100	(2)
Vasodilators, Cerebral	102	(4)
Vasodilators, Coronary	106	(1)
Vasodilators, Peripheral	107	(9)
Adrenomimetics	116	(110)
alpha-Adrenergic Agonists	116	(19)
beta-Adrenergic Agonists	135	(15)
Anorexics	150	(9)
Antidepressants	159	(18)
Antihypotensives	177	(4)
Bronchodilators	181	(25)
Cardiotonics	206	(6)
COMT Inhibitors	212	(1)
Decongestants	212	(6)
MAO Inhibitors	218	(4)
Mydriatics, Adrenergic	222	(2)
Tocolytics	224	(2)
Anticholinergic Agents	226	(54)
Anticholinergics	226	(35)
Antiparkinsonians	261	(9)
Antispasmodics	270	(9)
Mydriatics, Anticholinergic	279	(1)
Cholinomimetics	280	(13)
CCK Antagonists	280	(1)
Cholinergics	280	(6)
Cholinesterase Inhibitors	286	(4)
Gastroprokinetics	290	(1)
Miotics	291	(2)
Neuromuscular Junction/Ganglionic Agents	293	(30)
Cholinesterase Reactivators	293	(1)
Ganglionic Blocking Agents	294	(3)
Ganglionic Stimulants	297	(1)
Muscle Relaxants	298	(22)
Neuromuscular Transmission and Blocking Agents	320	(3)
PART II INDEXES	323	(124)
CAS Registry Number Index	325	(20)
EINECS Number Index	345	(12)
Name and Synonym Index	357	(90)
PART III MANUFACTURERS AND SUPPLIERS DIRECTORY	447