Ashgate Handbook of Cardiovascular Agents

by Milne, G. W. A.; Zeman, E. J.

• ISBN13: 9780566083860
• ISBN10: 0566083868
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-01-01
• Publisher: WILEY

Summary

The cardiovascular system serves to carry essential compounds to the tissues and to remove metabolic by-products. It also plays an important role in maintaining homeostasis, and functions directly or indirectly in the regulation of body temperature, oxygen supply, nutrient distribution, water and electrolyte balance, and endocrine activity. Consisting of a pump, connecting tubes, exchange membranes and blood, this system is governed by a diverse and complex array of regulatory mechanisms, encompassing central neural, autonomic, endocrine, paracrine, and autocrine control. Drugs used in the treatment of cardiovascular disease are disseminated widely in western industrialized countries. In the US alone, nearly $18 billion was spent on drugs for the treatment of cardiovascular disease and stroke in 1999. This Handbook contains records for all the major drugs that directly affect the cardiovascular system. Monographs are provided for over 1900 cardiovascular agents. For each main entry, the following information is provided: the chemical name and a list of proprietary names and synonyms; the Chemical Abstracts Service (CAS) Registry Number; the European Inventory of Existing Commercial Chemical Substances (EINECS) number; and the Merck Index (12th edition) number. The physical properties of each compound are described and the known biological activity and indicated applications are presented. The structure of each compound is provided, together with a summary of the acute toxicity data associated with it, and the manufacturers and suppliers of the drug are also given. Indexes, including a master index of names and synonyms, are appended.

Author Biography

G W A Milne was a Senior Researcher at the National Institutes of Health in Bethesda, MD, USA for 35 years where he worked on the use of spectroscopy for structure determination of organic compounds, and on molecular modeling in the design of drugs for the treatment of cancer and AIDS. He has been active for many years in the fields of chemical information and chemical computation and is the Editor of the American Chemical Society’s Journal of Chemical Information and Computer Science; Gardner’s Chemical Synonyms and Trade Names, Eleventh Edition (Ashgate); and Drugs: Synonyms and Properties (Ashgate).

E J Zeman received her PhD in physical chemistry from Northwestern University and completed a post-doctoral fellowship in computational chemistry at the University of Pittsburgh. She has worked in science publishing for over 12 years and has been on the staff of several peer-reviewed scientific journals. Dr Zeman has also written for and edited magazines, monographs, encyclopedias and reference books.

Table of Contents

Preface	ix
Acknowledgements	xi
How to Use This Book	xiii
Glossary of Units	xvii
Abbreviations and Symbols	xix
PART I MAIN ENTRIES
Vasoactive Agents	3	(13)
ACE Inhibitors	3	(9)
Angiotensin II Antagonists	12	(2)
Bradykinin Antagonists	14	(1)
Protease Inhibitors	15	(1)
Antihypertensive Agents	16	(142)
ACE Inhibitors	16	(1)
alpha-Adrenergic Blockers	16	(8)
beta-Adrenergic Blockers	24	(19)
Antihypertensives	43	(61)
Calcium-Channel Blockers	104	(15)
Diuretics	119	(22)
Ganglionic Blocking Agents	141	(3)
Peripheral Vasodilators	144	(14)
Antianginal, Antiarrhythmic, and Cardiotonic Agents	158	(91)
beta-Adrenergic Blockers	158	(1)
Antianginals	158	(23)
Antiarrhythmics	181	(34)
Bradycardiac Agents	215	(1)
Calcium-Channel Blockers	215	(1)
Cardiotonics	215	(20)
Coronary Vasodilators	235	(14)
Antihypercholesterolemic Agents	249	(18)
Antihyperlipoproteinemics	249	(16)
Cholelitholytic Agents	265	(1)
Lipotropics	266	(1)
Blood Formation and Coagulation Agents	267	(33)
Antifibrotics	267	(1)
Antineutropenics	268	(1)
Antithrombocythemics	269	(1)
Antithrombotics	269	(12)
Fibrinogen Receptor Antagonists	281	(1)
Hematinics	282	(5)
Hematopoietics	287	(1)
Hemolytics	288	(1)
Hemostatics	288	(5)
Thrombolytics	293	(5)
Thromboxane Inhibitors	298
Vasoprotectants	296	(4)
Water and Electrolyte Balancing Agents	300	(25)
Aldosterone Antagonists	300	(2)
Antidiarrheals	302	(4)
Antidiuretics	306	(2)
Antihyperphosphatemics	308	(1)
Antihypertensives	308	(1)
Antihypotensives	308	(4)
Carbonic Anhydrase Inhibitors	312	(2)
Diuretics	314	(1)
Ion Exchangers	314	(1)
Plasma Volume Expanders	314	(1)
Replenishers	315	(5)
Uricosurics	320	(5)
PART II INDEXES	325	(128)
CAS Registry Number Index	327	(20)
EINECS Number Index	347	(10)
Name and Synonym Index	357	(96)
PART III MANUFACTURERS AND SUPPLIERS DIRECTORY	453