Assessing and Modifying the Vulnerable Atherosclerotic Plaque

by Fuster, Valentin; Insull, William

• ISBN13: 9780879934859
• ISBN10: 0879934859
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-06-14
• Publisher: Wiley-Blackwell

Summary

Edited by Valentin Fuster, MD, PhD, former Chairman of the American Heart Association's Committee on Vascular Lesions, Assessing and Modifying the Vulnerable Atherosclerotic Plaque explores the most cutting-edge developments in a field grown richer through technological advances.This monograph is a valuable multidisciplinary resource, written by experts in the fields of mechanical and electrical engineering, pathology, neurology, imaging, clinical and vascular biology, physics, radiology and surgery. The book's nineteen chapters and five transcribed Panel Discussions provides a wealth of information on the identification and treatment of atherosclerotic plaques, including the latest diagnostic applications of numerous imaging techniques, the reasons for selecting a particular method, and what can be learned from the imaging results. Important insights into the structural and cellular components of vulnerable plaque are presented, as well as an examination of factors/activities that trigger thrombosis.

Author Biography

Valentin Fuster, MD, PhD, former Chairman of the American Heart Association's Committee on Vascular Lesions, Assessing and Modifying the Vulnerable Atherosclerotic Plaque explores the most cutting-edge developments in a field grown richer through technological advances.

Table of Contents

Historical Perspective	v
Contributors	ix
Evolving Concepts of Atherothrombosis	1	(28)
Valentin Fuster
Roberto Corti
Cerebrovascular Diseases: Pathophysiology and Management	29	(28)
Debabrata Mukherjee
Jay S. Yadav
Aortic Arch Vulnerable Plaques: Update	57	(28)
Pierre Amarenco
Ariel Cohen
The Vulnerable Atherosclerotic Plaque in Peripheral Vascular Disease	85	(16)
Michael L. Marin
Larry H. Hollier
Valentin Fuster
Jeffrey Goldman
Panel Discussion I. Overview of Pathology: Clinical Correlations of Atherosclerosis	101	(74)
Thermography: A Novel Approach for Identification of Plaques at Risk of Rupture and/or Thrombosis	107	(22)
Mohammad Madjid
Morteza Naghavi
James T. Willerson
Ward Casscells
Intravascular Ultrasound and Plaque Vulnerability: Evidence of a Systemic Disease Process	129	(14)
Paul Schoenhagen
Steven E. Nissen
Intracoronary Angioscopy to Detect Vulnerable Plaques: A Technique Whose Time Has Come?	143	(8)
Sergio Waxman
Electron Beam Computed Tomography in Assessing the Vulnerable Atherosclerotic Plaque	151	(16)
Robert A. O'Rourke
Multirow-Detector Helical Computed Tomography	167	(8)
Christoph R. Becker
Uwe J. Schoepf
Maximilian F. Reiser
Panel Discussion IIA. Overview of Imaging: Coronary Atherosclerosis	175	(44)
Imaging of the High-Risk Plaque Using Magnetic Resonance Imaging	181	(20)
Zahi A. Fayad
Valentin Fuster
Cardiovascular Imaging with Optical Coherence Tomography	201	(18)
Mark E. Brezinski
James Fujimoto
Panel Discussion IIB. Overview of Imaging: Atherosclerotic Regions and Imaging Modalities	219	(50)
Plaque Instability and Remodeling: Mechanisms and Possible Misconceptions	225	(16)
Trine-Line Korsholm
Gerard Pasterkamp
Erling Falk
Structural and Cellular Components of the Vulnerable Plaque: Extracellular Matrix	241	(10)
Renu Virmani
Frank D. Kolodgie
Allen P. Burke
Andrew Farb
Thomas N. Wight
Structural and Cellular Components of the Vulnerable Plaque: Inflammatory Cells	251	(18)
Allard C. van der Wal
Mischa A. Houtkamp
Onno J. de Boer
Anton E. Becker
Panel Discussion III. Structural and Cellular Components of the Vulnerable Atherosclerotic Plaque	269	(58)
Stress and Strain: Biomechanical Guides for Imaging Plaque Stability	277	(10)
Hayden Huang
Richard T. Lee
Endothelium, Flow, and Atherothrombosis	287	(20)
Roberto Corti
Lina Badimon
Valentin Fuster
Juan Jose Badimon
Activities that Trigger Plaque Disruption	307	(20)
Jagmeet P. Singh
James Januzzi
James E. Muller
Panel Discussion IV. Mechanical Forces in Plaque Disruption	327	(38)
Matrix Metalloproteinases and Their Inhibitors	335	(12)
Uwe Schonbeck
Peter Libby
Calcium Deposition in Vulnerable Atherosclerotic Plaques: Pathophysiologic Mechanisms and Potential Implications in the Acute Coronary Syndromes	347	(18)
Pedro R. Moreno
Panel Discussion V. Regulation of Functional Components of the Vulnerable Plaque	365	(6)
Index	371