Atherosclerosis, Hypertension and Diabetes

by Pierce, Grant N.; Nanago, Makoto, M.D.; Zahradka, Peter; Dhallia, Naranjan S., Ph.D.

• ISBN13: 9781402073113
• ISBN10: 1402073119
• Format: Hardcover
• Copyright: 2003-03-01
• Publisher: Kluwer Academic Pub

Summary

This volume is devoted to atherosclerosis, hypertension, and diabetes, three of the most important disease conditions in the world today. Nutritional intervention, cholesterol lowering agents, lipids themselves, particularly oxidized LDL, protein modification by ADP-ribose, bone marrow study, endothelial cell dysfunction, angiotensin, and the role of infection and inflammation are all discussed in the context of atherosclerotic cardiovascular disease.The hypertension section focuses on factors that may be responsible for high blood pressure, such as genetic predisposition, vascular hyperplasia and remodeling, insulin resistance, neurological aspects such as hypothalamic peptides. Also discussed are the possible contributions of the cellular function of the endothelium, nutrition, kidney dysfunction, leptin, and the brain. Novel routes of drug delivery for treatment of hypertension is also a focus.As for diabetes, the risk factors and mechanisms responsible for diabetic vascular and cardiac dysfunction are discussed. Lipid profile changes and fibrinolysis in diabetic patients is detailed, along with adipogenesis, diabetic cardiomyopathy, energy metabolism in the diabetic heart, vanadate as an alternative to insulin, insulin resistance mechanisms, and neurotransmitters as targets for the prevention of cardiovascular disease and diabetes.These manuscripts were invited from scientists who presented state of the art lectures at the XVII World Congress of the International Society for Heart Research held in Winnipeg in July 2001.

Table of Contents

Dedication: A Tribute to Dr. Setsuro Ebashi	xi
Preface	xv
Acknowledgements	xix
I. ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASE
PPAR-Alpha in Lipid and Lipoprotein Metabolism, Vascular Inflammation and Atherosclerosis	3	(14)
Jean-Charles Fruchart
Bart Staels
Patrick Duriez
The Choice of an Appropriate Animal Species in the Study of Chlamydia pneumoniae as an Atherogenic Agent	17	(10)
Satoru Hirono
Grant N. Pierce
Endothelial Cell Dysfunction---A Key Factor in Atherogenesis and its Reversal (Laboratory and Clinical Study)	27	(26)
Gurmukh S. Sainani
Manisha Sawhney Bhatia
Rajesh Sainani
Biochemical Mechanisms of Hyperhomocysteinemia in Atherosclerosis: Role of Chemokine Expression	53	(10)
Karmin O
Yaw L. Siow
Oxyradicals and Hypercholesterolemic Atherosclerosis	63	(8)
Paul Lee
Kailash Prasad
Identification, Regulation and Function of LOX-1, A Novel Receptor for Ox-LDL	71	(12)
Jacob Joseph
Dayuan Li
Hongjiang Chen
Jawahar L. Mehta
Atherosclerosis and Angiotensin II in Hypercholesterolemia and Diabetes. A Role for AT1 Receptors Beyond Hypertension	83	(16)
William B. Strewn
Richard H. Dean
Carlos M. Ferrario
Basic and Clinical Results of New Statin: Pitavastatin	99	(8)
Yasushi Saito
Reducing Cardiovascular Risk with HMG CoA Reductase Inhibitors, Potential Contribution From Platelets	107	(12)
Stephen Henry
Per L. Katzman
Ratna Bose
Yvette Perry
Shaun Walker
David Mymin
Peter Bolli
Rapamycin-Sensitive Signal Transduction Pathways and the Control of Adipogenesis	119	(12)
Alexander Sorisky
Annemarie Gagnon
Andrea Bell
Darine El-Chaar
II. HYPERTENSION
Genetic Predisposition to Hypertension and Cardiovascular Disease	131	(8)
Toshio Ogihara
Tomohiro Katsuya
Jitsuo Higaki
Role of Sympathetic Nervous System in Hypertension	139	(16)
Chaman Lal Kaul
Poduri Ramarao
Role of Hypothalamic Peptides in the Development of Hypertension	155	(8)
Pallab K. Ganguly
Manoj Chakravarty
Myosin Light Chain Kinase in Endothelial Cell Calcium Signaling and Endothelial Functions	163	(12)
Quang-Kim Tran
Hiroshi Watanabe
Sarpogrelate Inhibits Genes Involved in Vascular Neointimal Hyperplasia and Remodeling	175	(12)
Sushil K. Sharma
Nobuakira Takeda
Amarjit S. Arneja
Naranjan S. Dhalla
A Nutritional Approach to Prevent High Blood Pressure	187	(10)
Sudesh Vasdev
Carol Ann Ford
Linda Longerich
Sushil Parai
Cardiovascular and Renal Actions of Leptin	197	(14)
Prabal K. Guha
Daniel Villarreal
Garry P. Reams
Ronald H. Freeman
Brain Na, K-ATPase Enzymatic Activity and Cardiovascular Regulation	211	(18)
Mary-Anne H. Kent
James W. Van Huysse
Frans H. H. Leenen
Development of Transdermal and Transbuccal Drug Delivery Systems for Cardioactive Drugs with Special Reference to Anti-Hypertensive Agents	229	(18)
S. S. Agrawal
Insulin Resistance and Experimental Hypertension	247	(16)
Denise Galipeau
John H. Mcneill
III. DIABETES MELLITUS
New Paradigm for Insulin Resistance: The HISS Story	263	(14)
W. Wayne Lautt
Vanadium Effects in Diabetes	277	(12)
Tod A. Clark
Grant N. Pierce
Dyslipoproteinemia and Fibrinolysis	289	(12)
Garry X. Shen
Endothelins and Cardiovascular Disease in Diabetes	301	(16)
Subrata Chakrabarti
Usefulness of 5-HT2A Receptor Antagonists for the Treatment of Cardiovascular Complications in Diabetes	317	(10)
Ramesh K. Goyal
Dhananjay N. Umrani
Dipali N. Bodiwala
Naranjan S. Dhalla
Selective Attenuation of Enhanced Angiotensin II Mediated Responses in the Streptozotocin Diabetic Rat Thoracic Aorta by Tempol	327	(12)
Bettadapura N. Srikumar
Shailesh Shastri
Poduri Ramarao
Chaman Lal Kaul
Role of Renin-Angiotensin System in Diabetic Heart Dysfunction and Changes in Phospholipase C Activity	339	(14)
Paramjit S. Tappia
Sushma A. Mengi
Naranjan S. Dhalla
Regulation of Cardiac Function in Diabetes	353	(20)
Thomas Netticadan
Sharad Rastogi
Punam K. Chohan
Ramesh K. Goyal
Naranjan S. Dhalla
Diabetes and Cardiac Dysfunction	373	(14)
David L. Severson
Ellen Aasum
Darrell D. Belke
Terje S. Larsen
Lisa M. Semeniuk
Yakhin Shimoni
Mechanisms Underlying Contractile Dysfunction in Streptozotocin-Induced Type 1 and Type 2 Diabetic Cardiomyopathy	387	(22)
Nicolas K. Bracken
Jaipaul Singh
William Winlow
Frank C. Howarth
Protein Kinase C Signaling and Expression of the Diabetic Cardiac Phenotype	409	(18)
Barinder Pal Singh Kang
Babatunde Fasipe
Kameelah Broadway
Marjan Chegounchi
Leonard G. Meggs
Ashwani Malhotra
Oxidative Stress in Cardiovascular Complications of Diabetes	427	(12)
Firoozeh Farahmand
Huiquan Lou
Pawan K. Singal
Augmented Energy Transfer in Rat Heart Mitochondria: Compensatory Response to Abnormal Household of Energy in Acute Diabetes	439	(16)
Attila Ziegelhoffer
Iveta Waczulikova
Tanya Ravingerova
Barbara Ziegelhoffer-Mihalovicova
Jan Neckar
Jan Styk
Ketosis, Tumor Necrosis Factor-α and Cardiovascular Disease in Type-1 Diabetic Patients	455	(10)
Sushil K. Jain
Robert Mcvie
Joseph A. Bocchini Jr.
Epigenetic Alterations in Diabetic Cardiomyopathy	465	(16)
Patrick K. Umeda
Regina P. Shiau
Makesha Miggins
James B. Caulfield
Index	481