Atlas of Clinical Endocrinology, Diabetes

by Korenman, Stanley; Kahn, C. Ronald

• ISBN13: 9780632043996
• ISBN10: 0632043997
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-08-03
• Publisher: Wiley-Blackwell

Summary

The Atlas of Endocrinology series includes five lavishly illustrated volumes in which outstanding experts have contributed state of the art information and expert perspectives on current topics in the field. The series provides a detailed and comprehensive visual exposition of all aspects of clinical endocrinology.

Author Biography

Stanley Korenman is the author of Atlas of Clinical Endocrinology, Volume 2, Diabetes, published by Wiley. Carl Ronald Kahn is an American physician and scientist, best known for his work with insulin receptors and insulin resistance in diabetes and obesity.

Table of Contents

Regulation of Insulin Secretion and Islet Cell Function
Gordon C. Weir
Susan Bonner-Weir
Arun Sharma
Anatomy, Embryology, and Physiology	2	(7)
Insulin Secretion in Type 2 Diabetes	9	(7)
The Mechanisms of Insulin Action
Domenico Accili
Hiroko Kanno
Insulin Receptor	16	(1)
Overview of Insulin Effects	16	(2)
Role of Insulin Receptor Substrate Proteins in Insulin Signaling	18	(2)
Effectors of Insulin Action Downstream from Insulin Receptor Substrate	20	(2)
Alternative Signaling Pathways	22	(1)
Insulin Action on Glucose Metabolism	22	(3)
Other Actions of Insulin	25	(1)
Modulation of Insulin Action	26	(4)
Consequences of Insulin Deficiency
Abbas E. Kitabchi
Structure of the Islets of Langerhans	30	(2)
Definition and Criteria for Insulin-Deficient State	32	(3)
Pathophysiology of Insulin-Deficient State	35	(2)
Treatment of Acute Diabetic Complications	37	(8)
Type I Diabetes
Mark A. Atkinson
Clinical Description	45	(1)
Epidemiology	46	(2)
Genetics	48	(1)
Pathology	49	(8)
Future Directions	57	(3)
Management and Prevention of Complications in Type I Diabetes Mellitus
David M. Nathan
History of Type I Diabetes and Its Treatment	60	(1)
Therapy for Type I Diabetes	60	(3)
Results of Therapy:Glycemia	63	(1)
Long-term Complications: Pathophysiology and Results of Intensive Therapy	64	(3)
New Approaches to Therapy	67	(5)
The Pathogenesis of Type 2 Non-Insulin-Dependent Diabetes
C. Ronald Kahn
Pathogenesis of Type 2 Non-Insulin-Dependent Diabetes	72	(1)
The Role of Genes and the Environment	73	(3)
Insulin Action and Insulin Resistance at the Molecular Level	76	(3)
The Molecular Mechanisms of Insulin Resistance	79	(2)
The Physiologic Basis for Treatment of Type 2 Diabetes	81	(3)
Management and Prevention of Diabetic Complications
Sunder R. Mudaliar
Robert R. Henry
Complications of Diabetes	84	(9)
Future Directions	93	(2)
Insulin Resistance
Ele Ferrannini
Definition and Measurement	95	(2)
Insulin Action	97	(3)
Insulin Resistance	100	(4)
Insulin Resistance Syndrome	104	(6)
Hypoglycemia
John Service
Symptoms, Classification, and Glucose Behavior in Hypoglycemic Disorders	110	(9)
Survival Rates and Recurrence	119	(2)
Mechanisms of Hyperglycemic Damage in Diabetes
Michael Brownlee
Target-Organ Specificity of Hyperglycemic Damage	121	(1)
Major Mechanisms of Hyperglycemic Damage	122	(7)
Interrelationship of Mechanisms of Hyperglycemic Damage	129	(1)
Potential Role of Insulin Resistance	130	(1)
Genetics of Susceptibility to Complications	131	(1)
Development of Complications During Posthyperglycemic Euglycemia	131	(4)
Eye Complications of Diabetes
Lloyd Paul Aiello
Anatomy, Symptoms, and Pathology	135	(2)
Nonproliferative Diabetic Retinopathy	137	(2)
Proliferative Diabetic Retinopathy and Macular Edema	139	(2)
Complications and Causes of Visual Loss	141	(3)
Treatment	144	(4)
Growth Factors and Potential Novel Therapies	148	(3)
Diabetes and the Kidney
Robert C. Stanton
Demographics and Incidence	151	(1)
Diabetic Nephropathy Diagnosis	152	(6)
Treatment and Prevention	158	(6)
Diabetic Neuropathies
Aaron Vinik
Pathogenesis	164	(1)
Mononeuropathy and Entrapment	165	(1)
Distal Neuropathy	166	(1)
Components of Cutaneous Nerve	166	(1)
Large Fiber Neuropathy	167	(2)
C-Fiber Dysfunction in Small Fiber Neuropathy	169	(2)
Neuroarthropathy	171	(1)
Autonomic Neuropathy	172	(2)
Gastropathy	174	(6)
Secondary Forms of Diabetes
Veronica M. Catanese
Abnormal Glucose Homeostasis Secondary to Endocrinologic Disorders: Acromegaly	180	(1)
Cushing Syndrome	181	(2)
Glucagonoma	183	(1)
Pheochromocytoma	184	(1)
Thyrotoxicosis	185	(1)
Hyperprolactinemia	185	(1)
Pancreatoprivic Diabetes: Pancreatectomy and Chronic Pancreatitis	186	(1)
Hemochromatosis	186	(1)
Pharmacologic Effects on Glucose Homeostasis	187	(1)
Genetic Syndromes Affecting Glucose Tolerance	188	(3)
Obesity
Eleftheria Maratos-Flier
Prevalence of Obesity	191	(1)
Obesity and the Risk for Other Diseases	192	(1)
Role of Molecular Mechanisms	192	(2)
Role of Monogenic Mechanisms	194	(5)
Treatment of Obesity	199	(3)
Relative Risk for Obesity	202	(3)
Index	205