Autoimmune Diseases and Treatment Organ-Specific and Systemic Disorders, Volume 1051

by Shoenfeld, Yehuda; Gershwin, M. Eric

• ISBN13: 9781573316132
• ISBN10: 157331613X
• Edition: 1st
• Format: Paperback
• Copyright: 2005-08-26
• Publisher: Wiley-Blackwell

Summary

Only in very recent times have therapies been developed that are specific to a particular manifestation of autoimmune disease, and these have begun to replace the all-purpose remedies of the past 30 years. This volume, which draws on the principles of immunology presented in Volume 1050 (Autoimmunity: Concepts and Diagnosis at the Cutting Edge), extends these concepts to the realm of clinical findings and current therapy for many autoimmune and connective tissue disorders. Both organ-specific and organ-nonspecific diseases are covered, and one section is entirely focused on treatment. Treatments using cytokines, chemokines, cognate receptors, and genetic interactions are particularly prominent in these reports, and attention is also paid to the increasing use of intravenous imunoglobulins and both monoclonal and imunosuppressive agents. A therapeutic void remains, but the work reported on here contributes considerably to the effort to fill that void. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

Yehuda Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair of Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. He is also Founder of the Center for Autoimmune Diseases, both at the Sheba Medical Center in Tel Hashomer, Israel.

Table of Contents

Foreword. By YEHUDA SHOENFELD AND M. ERIC GERSHWIN	xiii
Part I. Organ-Specific Autoimmune Diseases
Activation, Apoptosis, and Clearance of Neutrophils in Wegener's Granulomatosis. By ANDRÉ P. VAN ROSSUM, PIETER C. LIMBURG, AND CEES G.M. KALLENBERG	1	(11)
Is PR3-ANCA Formation Initiated in Wegener's Granulomatosis Lesions? Granulomas as Potential Lymphoid Tissue Maintaining Autoantibody Production. By J. VOSWINKEL, A. MÜLLER, AND P. LAMPRECHT	12	(8)
Clinical Relevance of Antiphospholipid Antibodies in Primary Biliary Cirrhosis. By PHILIPP VON LANDENBERG, MICHAEL BAUMGARTNER, JUERGEN SCHOELMERICH, KARL J. LACKNER, AND REINHILD KLEIN	20	(9)
IL-10 and the Cytokine Network in the Pathogenesis of Human Autoimmune Hemolytic Anemia. By CATERINA TORIANI-TERENZI AND ENZO FAGIOLO .	29	(16)
Crohn's Disease Is Associated with Polymorphism of CARD15/NOD2 Gene in a Hungarian Population. By ZSUZSANNA NAGY, OSZKÁR KARÁDI, GYÖRGY RUMI, GYÖRGY RUMI, JR., ALAJOS PÁR, GYULA MÓZSIK, LÁSZLÓ CZIRJÁK, AND GÁBOR SÜTO	45	(7)
Apoptosis in Human Skin: Role in Pathogenesis of Various Diseases and Relevance for Therapy. By ESTHER REEFMAN, PIETER C. LIMBURG, CEES G. M. KALLENBERG, AND MARC BIJL	52	(12)
Cancer-Associated Myositis: Clinical Features and Prognostic Signs. By ANDREA PONYI, TAMÁS CONSTANTIN, MIKLÓS GARAMI, CSILLA ANDRÁS, BÉLA TÁLLAI, ANDREA VÁNCSA, LAJOS GERGELY, AND KATALIN DANKÓ	64	(8)
Control of Type 1 Autoimmune Diabetes by Naturally Occurring CD4+CD25+ Regulatory T Lymphocytes in Neonatal NOD Mice. By C.A. PICCIRILLO, M. TRITT, E. SGOUROUDIS, A. ALBANESE, M. PYZIK, AND V. HAY	72	(16)
The Role of Methallothioneins in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. By CARMEN ESPEJO AND EVA M. MARTINEZ-CÁCERES	88	(9)
Oxidized Low-Density Lipoprotein/β2-Glycoprotein I Complexes and Autoantibodies in Patients with Type 2 Diabetes Mellitus. By Luis R. LOPEZ, BETH L. HURLEY, DANIEL F. SIMPSON, AND EIJI MATSUURA	97	(7)
Autoantibodies to Human α6 Integrin in Patients with Bullous Pemphigoid. By MÁRIA KISS, ÁDÁM PERENYI, ILONA MARCZINOVITS, JÁNOS MOLNÁR, ATTILA DOBOZY, LAJOS KEMÉNY, AND SÁNDOR HUSZ	104	(7)
Soluble HLA Class I and Class II Molecules in Relapsing-Remitting Multiple Sclerosis: Acute Response to Interferon-β1a Treatment and Their Use as Markers of Disease Activity. By ALIREZA MINAGAR IRENA ADAMASHVILLI, STEPHEN L. JAFFE, MICHAEL F. GLABUS, EDUARDO GONZALEZ-TOLEDO, AND ROGER E. KELLEY	111	(10)
Proinflammatory Cytokines and Autoimmunity in Churg-Strauss Syndrome. By B. HELLMICH, E. CSERNOK, AND W.L. GROSS	121	(11)
Rheumatic Fever: How S. pyogenes–Primed Peripheral T Cells Trigger Heart Valve Lesions. By L. GUILHERME, K.C. FAÉ, S.E. OSHIRO, A.C. TANAKA, P.M.A. POMERANTZEFF, AND J. KALIL	132	(9)
Avidity of Anti-β2-Glycoprotein I and Thrombosis or Pregnancy Loss in Patients with Antiphospholipid Syndrome. By S. CUCNIK, B. BOŽIC, T. KVEDER, M. TOMSIC, AND B. ROZMAN	141	(7)
Neurological Complications of Celiac Disease and Autoimmune Mechanisms: Preliminary Data of a Prospective Study in Adult Patients. By C. BRIANI, G. ZARA, E. TOFFANIN, S. RUGGERO, A. FERRARINI, F. DE LAZZARI, M. LUCA, D. FAGGIAN, F. GRASSIVARO, M. ERMANI, R. PEZZANI, B. GIOMETTO, AND A. D' ODORICO	148	(8)
E2F1¯/¯ C57BL/6 Mice Overexpressing a Human Bc1-2 Transgene in B Cells Develop a Mild Autoimmune Syndrome. By MARIA J. MARIN, ITXASO GARCIA, MARTA PEÑA, AINHOA BOLIVAR, ANA ZUBIAGA, AND MARCOS LÓPEZ-HOYOS	156	(10)
Systemic Thromboembolism in Inflammatory Bowel Disease: Mechanisms and Clinical Applications. By GILAD TWIG, GISELE ZANDMAN-GODDARD, MARTINE SZYPER-KRAVITZ, AND YEHUDA SHOENFELD	166	(8)
Pregnancy Loss and Endometriosis: Pathogenic Role of Anti-Laminin-1 Autoantibodies. By JUNKO INAGAKI, AKANE KONDO, LUIS R. LOPEZ, YEHUDA SHOENFELD, AND EIJI MATSUURA	174	(11)
Primary Biliary Cirrhosis: Solving the Enigma. By ALESSIA GIORGINI, CARLO SELMI, PIETRO INVERNIZZI, MAURO PODDA, MASSIMO ZUIN, AND M. ERIC GERSHWIN	185	(9)
The Stages of Type 1A Diabetes. By NARU BABAYA, MAKI NAKAYAMA, AND GEORGE S. EISENBARTH	194	(11)
Soluble CD4OL in Plasma of Patients with Primary Biliary Cirrhosis. By SABINE OERTELT, PIETRO INVERNIZZI, CARLO SELMI, MAURO PODDA, AND M. ERIC GERSHWIN	205	(6)
Decreased Serum Leptin Levels in Primary Biliary Cirrhosis: A Link between Metabolism and Autoimmunity? By ROMAN RIEGER, SABINE OERTELT, CARLO SELMI, PIETRO INVERNIZZI, MAURO PODDA, AND M. ERIC GERSHWIN	211	(7)
Analysis of the Foxp3/Scurfin Gene in Crohn's Disease. By OGYI PARK, IRINA GRISHINA, PATRICK S. LEUNG, M. ERIC GERSHWIN, AND T. PRINDIVILLE	218	(11)
Part II. Systematic Autoimmune Diseases
Juvenile Systemic Sclerosis: A Follow-up Study of Eight Patients. By SZILVIA SZAMOSI, LÁSZLÓ MARÓDI, LÁSZLÓ CZIRJÁK, ZOLTÁN ELLENES, AND GABRIELLA SZÜCS	229	(6)
Antifodrin Antibodies in Sjögren' s Syndrome: A Review. By TORSTEN WITTE	235	(5)
Generation and Characterization of Three Monoclonal IgM Antiphospholipid Antibodies Recognizing Different Phospholipid Antigens. By CATHARINA BUSCHMANN, CHRISTIAN FISCHER, VIOLA OCHSENHIRT, CAROLIN NEUKIRCH, KARL J. LACKNER, AND PHILIPP VON LANDENBERG	240	(15)
Premature Immunosenescence in Rheumatoid Arthritis and Multiple Sclerosis Patients. By MARIELLE THEWISSEN, LOES LINSEN, VEERLE SOMERS, PIET GEUSENS, JEF RAUS, AND PIET STINISSEN	255	(8)
Association of Rheumatoid Arthritis with HLA-DR1 and HLA-DR4 in Hungary. By ANOKÓ KAPITÁNY, ERIKA ZILAHI, SÁNDOR SZÁNTÓ, GABRIELLA SZÜCS, ZOLTÁN SZABÓ, ANIKÓ VÉGVARI, PÉTER RASS, SÁNDOR SIPKA, GYULA SZEGEDI, AND ZOLTÁN SZEKANECZ	263	(8)
Plasminogen Activator Inhibitor-1 Is Associated with Impaired Endothelial Function in Women with Systemic Lupus Erythematosus. By EMILY C. SOMERS, WENDY MARDER, MARIANA J. KAPLAN, ROBERT D.BROOK, AND W. JOSEPH MCCUNE	271	(10)
Early Atherosclerosis in Rheumatoid Arthritis: Effects of Smoking on Thickness of the Carotid Artery Intima Media. By ROBERTO GERLI, YANIV SHERER, GAETANO VAUDO, GIUSEPPE SCHILLACI, BORIS GILBURD, ANDREA GIORDANO, ELENA BARTOLONI BOCCI, ROSITA ALLEGRUCCI, SIMONA MARCHESI, ELMO MANNARINO, AND YEHUDA SHOENFELD	281	(10)
Investigation of Arthritic Joint Destruction by a Novel Fibroblast-Based Model. By U. SACK, B. SEHM, F. KAHLENBERG, A. MURR, J. LEHMANN, A. TANNAPFEL, K. UBERLA, A. MOESSNER, A. DIETRICH, F. EMMRICH, F. LANGE, A. JUNGEL, J-M. BRAUN, AND U. ANDEREGG	291	(8)
Prevalence of Antiphospholipid and Antioxidized Low-Density Lipoprotein Antibodies in Rheumatoid Arthritis. By YANIV SHERER, ROBERTO GERLI, GAETANO VAUDO, GIUSEPPE SCHILLACI, BORIS GILBURD, ANDREA GIORDANO, ELENA BARTOLONI BOCCI, ROSITA ALLEGRUCCI, SIMONA MARCHESI, ELMO MANNARINO, AND YEHUDA SHOENFELD	299	(5)
Mono-organic versus Multi-organic Involvement in Primary Antiphospholipid Syndrome. By GABRIELA MEDINA, OLGA VERA-LASTRA, ULISES ANGELES, AND LUIS J. JARA	304	(9)
OxLDL/β2GPI Complexes and Autoantibodies in Patients with Systemic Lupus Erythematosus, Systemic Sclerosis, and Antiphospholipid Syndrome: Pathogenic Implications for Vascular Involvement. By LUIS R. LOPEZ, DANIEL F. SIMPSON, BETH L. HURLEY, AND EIJI MATSUURA	313	(10)
Anti-HSP60 Immunity Is Already Associated with Atherosclerosis Early in Life. By M. KNOFLACH, D. BERNHARD, AND G. WICK	323	(9)
Determinants of Vessel Targeting in Vasculitis. By GARY S. HOFFMAN	332	(8)
Lymphocyte Activation as a Possible Measure of Atherosclerotic Risk in Patients with Sleep Apnea. By LARISSA DYUGOVSKAYA, PERETZ LAVIE, AND LENA LAVIE	340	(11)
Systemic Lupus Erythematosus, Atherosclerosis, and Autoantibodies. By SANDRA ZAMPIERI, LUCA IACCARINO, ANNA GHIRARDELLO, ELENA TARRICONE, SILVIA ARIENTI, PIERCARLO SARZI-PUTTINI, PIER FRANCA GAMBARI, AND ANDREA DORIA	351	(11)
Accelerated Atherosclerosis in Patients with Systemic Autoimmune Diseases By KARINA DE LEEUW, CEES KALLENBERG, AND MARC BIM	362	(10)
Nocturnal Hormones and Clinical Rhythms in Rheumatoid Arthritis. By MAURIZIO CUTOLO, KATI OTSA, OIVI AAKRE, AND ALBERTO SULLI	372	(10)
Xenobiotic-Induced Recruitment of Autoantigens to Nuclear Proteasomes Suggests a Role for Altered Antigen Processing in Scleroderma. By MIN CHEN AND ANNA VON MIKECZ	382	(8)
Humoral Antigenic Targets of the Ribosomal P0 Lupus Autoantigen Are Not Limited to the Carboxyl Region. By BENJAMIN F. BRUNER, DONNY M. WYNN, MORRIS REICHLIN, JOHN B. HARLEY, AND JUDITH A. JAMES	390	(14)
Clinical Correlations of Potential Activity Markers in Systemic Sclerosis. By R. BECVAR, J. ŠTORK, V. PEŠAKOVA, A. STANOVÁ, H. HULEJOVÁ, L. RYSOVÁ, A. ZATLOUKALOVÁ, P. ZATLOUKAL, M. JÁCHYMOVÁ, AND L. POUROVÁ	404	(9)
Complement Activation: A Novel Pathogenic Mechanism in the Antiphospholipid Syndrome. By SILVIA S. PIERANGELI, MARIANO VEGA-OSTERTAG, XIAOWEI LIU, AND GUILLERMINA GIRARDI	413	(8)
The Interplay of Chemokines and Dendritic Cells in the Pathogenesis of Lupus Nephritis. By MARCO TUCCI, NICOLA CALVANI, HANNO B. RICHARDS, COSIMA QUATRARO, AND FRANCO SILVESTRIS	421	(12)
Cellular and Molecular Mechanisms of Regulation of Autoantibody Production in Lupus. By BEVRA H. HAHN, FANNY EBLING, RAM R. SINGH, RAM P. SINGH, GEORGE KARPOUZAS, AND ANTONIO LA CAVA	433	(9)
The Role of Innate and Adaptive Immunity to Oxidized Low-Density Lipoprotein in the Development of Atherosclerosis. By KAZUKO KOBAYASHI, LUIS R. LOPEZ, YEHUDA SHOENFELD, AND EIJI MATSUURA	442	(13)
Predictive Markers for Development of Severe Organ Involvement in Patients with Systemic Sclerosis. By LAURE YSEBRANT DE LENDONCK, ANNICK OCMANT, FLORENCE ROUFOSSE, AND ELIE COGAN	455	(10)
Hughes Syndrome, the Antiphospholipid Syndrome: A New Chapter in Neurology. By GIOVANNI SANNA, MARIA LAURA BERTOLACCINI, AND GRAHAM R. V. HUGHES	465	(22)
New Facet of Antiphospholipid Antibodies. By GUIDO VALESINI AND CRISTIANO ALESSANDRI	487	(11)
Part III. Treatment
Inhibitor Development in Patients with Hemophilia A after Continuous Infusion of FVIII Concentrates. By CH. VON AUER, J. OLDENBURG, M. VON DEPKA, C. ESCURIOLA-ETTINGHAUSEN, K. KURNIK, H. LENK, AND I. SCHARRER	498	(8)
Increased Spontaneous Apoptosis of CD4+CD25+ T Cells in Patients with Active Rheumatoid Arthritis Is Reduced by Infliximab. By E. TOUBI, A. KESSEL, Z. MAHMUDOV, K. HALLAS, M. ROZENBAUM, AND I. ROSNER	506	(9)
Synergistic Effect of Avemar on Proinflammatory Cytokine Production and Ras-Mediated Cell Activation. By ANDRÁS TELEKES, ENDRE KISS-TÓTH, TÜNDE NAGY, EVA E. QWARNSTROM, ERZSÉBET KÚSZ, TIMEA POLGÁR, AKOS RESETÁR, STEVEN K. DOWER, AND ERNO DUDA	515	(14)
Fermented Wheat Germ Extract (Avemar) in the Treatment of Cancer and Autoimmune Diseases. By LASZLO G. BOROS, MICHELE NICHELATTI, AND YEHUDA SHOENFELD	529	(14)
Open-Label 24-Month Study Evaluating Infliximab Therapy in Patients with Psoriatic Spondyloarthropathy. By J.J. SCALI, A. KAMINSKY, J. SALOMÓN, S. VISENTINI, AND E. DANCZIGER	543	(8)
Cyclosporine: From Renal Transplantation to Autoimmune Diseases. By CLAUDIO PONTICELLI	551	(8)
Autoimmunity and Anti–TNF-α Agents. By FABIOLA ATZENI, MAURIZIO TURIEL, FRANCO CAPSONI, ANDREA DORIA, PIERLUIGI MERONI, AND PIERCARLO SARZI-PUTTINI	559	(11)
Combination Treatment of Rat Adjuvant-Induced Arthritis with Methotrexate, Probiotic Bacteria Enterococcus faecium, and Selenium. By JOZEF ROVENSKY, KAROL ŠVIK, VLADIMIR MATHA, RICHARD IŠTOK, VOJTECH KAMARÁD, LIBOR EBRINGER, MIROSLAV FERENCIK, AND MÁRIA STANCIKOVÁ	570	(12)
Comparative Analysis of Antigen Specificities in the Monomeric and Dimeric Fractions of Intravenous Immunoglobulin. By SYLVIA M. MIESCHER, ALEXANDER SCHAUB, MARCO GHIELMETTI, MICHAEL BAUMANN, MONIQUE VOGEL, REINHARD BOLLI, AND BEDA STADLER	582	(9)
Treatment of Pemphigus Vulgaris with Protein A Immunoadsorption: Case Report of Long-Term History Showing Favorable Outcome. By NINA FROST, GERALD MESSER, GERHARD FIERLBECK, TEUT RISLER, AND SIMON D. LYTTON	591	(6)
Immunosuppressive Therapy and Clinical Evolution in Forty-nine Patients with Antineutrophil Cytoplasmic Antibody–Associated Glomerulonephritis. By E. KOKOLINA, E. ALEXOPOULOS, C. DIMITRIADIS, A. VAINAS, P. GIAMALIS, A. PAPAGIANNI, D. EKONOMIDOU, AND D. MEMMOS	597	(9)
Management of Thrombosis in Antiphospholipid Syndrome and Systemic Lupus Erythematosus in Pregnancy. By GUILLERMO RUIZ-IRASTORZA AND MUNTHER A. KHAMASHTA	606	(7)
Gene-Gun Biolistic Immunization Encoding Glutamic Acid Decarboxylase: A Model for Studying Langerhans Cell Abnormalities and Mimicry in the Nonobese Diabetic Mouse. By BÉATRICE JOUSSEMET, ANH-TUAN VU, PIERRE SAI, AND JEAN-MARIE BACH	613	(13)
Intra-bone Marrow–Bone Marrow Transplantation: A New Strategy for Treatment of Stem Cell Disorders. By SUSUMU IKEHARA	626	(9)
Removal of Pathogenic Autoantibodies by Immunoadsorption. By ALON Y. HERSHKO AND YAAKOV NAPARSTEK	635	(12)
Chemokine Receptors: Attractive Targets for Drug Discovery. By NURIA GODESSART	647	(11)
Rationale for T Cell Inhibition by Cyclosporin A in Major Autoimmune Diseases. By G.F. FERRACCIOLI, P. TOMIETTO, AND M. DE SANTIS	658	(8)
Partial Response to Anti-CD20 Monoclonal Antibody Treatment of Severe Immune Thrombocytopenic Purpura in a Patient with Common Variable Immunodeficiency. By J. CARBONE, A. ESCUDERO, M. MAYAYO, M. BALLESTEROS, A. PEREZ-CORRAL, S. SANCHEZ-RAMON, E. SARMIENTO, D. MICHELOUD, AND E. FERNANDEZ-CRUZ	666	(6)
CD20 Mimicry by a mAb Rituximab-Specific Linear Peptide: A Potential Tool for Active Immunotherapy of Autoimmune Diseases. By FEDERICO PEROSA, ELVIRA FAVOINO, MARIA ANTONIETTA CARAGNANO, AND FRANCO DAMMACCO	672	(12)
Anticytokine Therapy, Especially Anti–Interferon-γ, as a Pathogenetic Treatment in TH-1 Autoimmune Diseases. By SIMON SKURKOVICH AND BORIS SKURKOVICH	684	(17)
Therapeutic T Cell–Based Vaccination for Neurodegenerative Disorders: The Role of CD4+CD25+ Regulatory T Cells. By MICHAL SCHWARTZ AND JONATHAN KIPNIS	701	(8)
Tumor Necrosis Factor Inhibitor Therapy for Rheumatoid Arthritis. By STANLEY M. NAGUWA	709	(7)
Pathogenesis of Rheumatoid Arthritis: Targeting Cytokines. By JOCHE ZWERINA, KURT REDLICH, GEORG SCHETT, AND JOSEF S. SMOLEN	716	(14)
Anti-inflammatory and Immune Regulatory Properties of 5-Androsten-3β, 17β-Diol (HE2100), and Synthetic Analogue HE3204: Implications for Treatment of Autoimmune Diseases. By D. Auci, F. NICOLETTI, K. MANGANO, R. PIETERS, S. NIERKENS, L. MORGAN, H. OFFNER, J. FRINCKE, AND C. READING	730	(13)
Inmunomodulatory Effects of Intravenous Immunoglobulins as a Treatment for Autoimmune Diseases, Cancer, and Recurrent Pregnancy Loss. By TAL SAPIR, MIRI BLANK, AND YEHUDA SHOENFELD	743	(36)
Response of Vasculitic Peripheral Neuropathy to Intravenous Immunoglobulin. By YAIR LEVY, YOSEF UZIEL, GIESELE ZANDMAN, PNINA ROTMAN, HAWARED AMITAL, YANIV SHERER, PNINA LANGEVITZ, BOLECK GOLDMAN, AND YEHUDA SHOENFELD	779	(8)
Involvement of Innate Immunity in the Development of Inflammatory and Autoimmune Diseases. By HELENA TLASKALOVÁ-HOGENOVÁ, LUDMILA TUCKOVÁ, RENATA STEPANKOVÁ, TOMÁS HUDCOVIC, LENKA PALOVÁ-JELINKOVÁ, HANA KOZÁKOVCÁ, PAVEL ROSSMANN, DANIEL SANCHEZ, JANA CINOVÁ, TOMAS HRNCIR, MILOSLAV KVERKA, LENKA FROLOVÁ, HOLM UHLIG, FIONA POWRIE, AND PAUL BLAND	787	(12)
Do We Need New Treatment That Goes beyond Tumor Necrosis Factor Blockers for Rheumatoid Arthritis? By REINHARD E. VOLL AND JOACHIM R. KALDEN	799	(12)
Index of Contributors	811