Autoimmune Rheumatic Disease

by Morrow, John; Nelson, J. Lee; Watts, Richard; Isenberg, David

• ISBN13: 9780192628831
• ISBN10: 0192628836
• Edition: 2nd
• Format: Hardcover
• Copyright: 1999-04-22
• Publisher: Oxford University Press

Summary

This is a new fully revised edition of an award winning title. It fills a gap in the literature in that no other book bridges the divide between the clinical characterisation and treatment of autoimmune rheumatic diseases on the one hand and an understanding of laboratory-based research anddisease pathogenesis on the other. This second edition is especially important because it describes and explains advances in molecular biological techniques which have brought about major changes in understanding. It also covers the new therapies which have been developed for many autoimmunerheumatic diseases.

Table of Contents

Introduction:the immune system-order and disorder
Introduction	1	(1)
The normal immune response	1	(8)
Organisation of the lymphoid system	9	(1)
The cell of the immune system	9	(5)
HLA genes and molecules	14	(5)
Immune tolerance	19	(2)
The immune system in concert	21	(2)
References	23	(1)
Immunological methodology
Introduction	24	(1)
Fundamental of practical immunology	24	(8)
Immunological tests used for evaluation of the autoimmune rheumatic diseases	32	(10)
Summary	42	(1)
References	42	(1)
Therapeutic manipulation of the immune system
Introduction	43	(1)
Established non-selective immunotherapy	44	(2)
Non-selective therapies under investigation	46	(2)
Selective immunotherapy	48	(4)
Summary	52	(1)
References	52	(4)
Systematic lupus erythematosus
Introduction	56	(1)
Milestones in the history of Sle	56	(1)
Definition and classification	57	(1)
Epidemiology and natural history	57	(1)
Clinical feature	58	(10)
Sle in children	68	(1)
Sle and pregnancy	69	(1)
Lupus in other situations	69	(1)
Immunogenetics	70	(3)
Experimental models of SLE	73	(3)
Immunopathology of SLE	76	(1)
Cellular dysregulation	76	(15)
Management of SLE	91	(5)
Summary	96	(1)
References	96	(8)
Rheumatoid arthritis
Introduction	104	(1)
Milestones in the history of RA	104	(1)
Classification	105	(1)
Epidemiology and outcome	105	(1)
The clinical picture	106	(5)
Clinical assessment of patients	111	(1)
Complications and associated disorders	111	(2)
Investigations in RA	113	(3)
Immunogenetics	116	(5)
Animal models	121	(4)
Immunopathogenesis of RA	125	(6)
Management of RA	131	(8)
Summary	139	(1)
References	140	(7)
Sjogrens syndrome
Introduction	147	(1)
Milestones in the history of Sjogren's syndrome	147	(1)
Classification of Sjogren's syndrome	148	(1)
The clinical picture	148	(9)
Immunogenetics	157	(2)
Experimental models	159	(2)
Aetiopathogenesis	161	(4)
Treatment	165	(1)
Summary	166	(1)
References	166	(4)
Polymyositis
Introduction	170	(1)
Milestones in the history of myositis	170	(1)
The clinical picture	170	(3)
Systemic feature	173	(3)
Laboratory investigations	176	(7)
Aetiology and pathogenesis	183	(1)
Immunogenetics	184	(1)
Animal Models	185	(1)
Pathogenic mechanisms	186	(3)
Treatment of myositis in adults	189	(1)
Summary	190	(1)
References	190	(4)
Scleroderma
Introduction	194	(1)
Milestones in the history of scleroderma	194	(1)
Clinical features	194	(11)
Outcome	205	(1)
Immunogenetics	205	(2)
Animal models	207	(2)
Pathogenesis of scleroderma	209	(1)
Treatment	210	(2)
Summary	212	(1)
Reference	213	(3)
Primary anti-phospholipid antibody syndrome
Introduction	216	(1)
Milestone in the history of APS	216	(2)
Clinical features	218	(2)
Anti-phospholipid antibody syndrome in children	220	(1)
Immunogenetics	220	(2)
Animal models of APS	222	(2)
Immunopathology, including laboratory tests	224	(4)
Management of APS	228	(1)
Summary	229	(1)
References	229	(4)
Overlap syndromes
Introduction	233	(1)
Milestones in the history of overlap syndromes	233	(1)
Mixed connective tissue disease	233	(5)
tRNA synthetase syndrome	238	(1)
Scleroderma/polymyositis overlap	238	(1)
SLE/Sjogren's syndrome overlap	239	(1)
Rhupus	239	(1)
Immunogenetics	239	(1)
Summary	239	(1)
Reference	239	(3)
Vasculitis
Introduction	242	(1)
Milestone in the history of systemic vasculitis	242	(1)
Systemic vasculities in humans	243	(1)
Diagnostic criteria for individual diseases	243	(2)
Epidemiology	245	(1)
The clinical picture	245	(8)
Vasculities in children	253	(2)
Investigation of vasculities	255	(1)
Aetiopathogenesis	255	(3)
Animal model	258	(1)
Immunogenetics	259	(3)
Prognosis and mortality	262	(1)
Management and treatment	263	(2)
Summary	265	(1)
References	265	(6)
Index	271