Autoimmunity : Concepts and Diagnosis at the Cutting Edge

by Gershwin, M. Eric; Shoenfeld, Yehuda

• ISBN13: 9781573315173
• ISBN10: 1573315176
• Format: Paperback
• Copyright: 2005-06-24
• Publisher: Wiley-Blackwell

Summary

Only 40 years ago, the first textbook on autoimmunity was published, and at that time many scientists and clinicians were unconvinced that a process such as autoimmunity even existed. Today, the field is exploding with advances in our understanding of the major histocompatibility complexes, the production of monoclonal antibodies and the resulting identification of distinct cell phenotypes and demonstration of accessory and secondary molecules and messengers, including complement, cytokines, chemokines, and the cognate receptors, to name a few.Both novel scientific (basic immunology) and clinical aspects of autoimmunity and autoimmune diseases are presented in this volume and in Volume 1051 (Autoimmune Disease and Treatment: Organ-Specific and Systemic Disorders) in papers written by the world's leading autoimmunologists.Topics covered in this volumes include etiology and pathogenesis, genetics, mechanisms, tolerance, diagnostics, the role of hormones, infection, animal models, individual autoimmune diseases, therapy, and the art and science of predicting autoimmunity.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Table of Contents

Foreword

Principles of Autoimmunity

Posttranslational Modifications of Self-Antigens

Expression and Reexpression of Recombination Activating Genes: Relevance to the Development of Autoimmune States

B Lymphocytes Are Required for Development and Treatment of Autoimmune Diseases

BAFF Overexpression Is Associated with Autoantibody Production in Autoimmune Diseases

Histo-Blood Group Antigens as Allo- and Autoantigens

The Mechanism of Molecular Redundancy in Autoimmune Inflammation in the Context of CD44 Deficiency

Functional Genomics in Early Autoimmunity

IgE and FcRI Regulation

Interspecific Structural Differences in Nucleosome as Revealed by Heteroimmunization in Mice with Human Nucleosome

Differential Regulation of the IL-10 Gene in Th1 and Th2 T Cells

Central Memory and Effector Memory Subsets of Human CD4+ and CD8+ T Cells Display Differential Sensitivity to TNF--Induced Apoptosis

Non-Antigen-Specific CD8+ T Suppressor Lymphocytes in Diseases Characterized by Chronic Immune Responses and Inflammation

Long-Lived Plasma Cells and Their Contribution to Autoimmunity

What Makes an Autoantigen an Autoantigen?

DNA Lesions and Repair in Immunoglobulin Class Switch Recombination and Somatic Hypermutation

Diagnostic Considerations of Autoimmunity

Cross-Reactivity of IgM and IgG Anticardiolipin Antibodies with Oxidized-Low Density Lipoproteins

The Anti-Alpha-Actinin Test Completes Anti-DNA Determination in Systemic Lupus Erythematosus

The Relevance of Autoantigen Source and Cutoff Definition in Antichromatin (Nucleosome) Antibody Immunoassays

Value of a New Automated Fluorescence Immunoassay (EliA) for PR3 and MPO-ANCA in Monitoring Disease Activity in ANCA-Associated Systemic Vasculitis

Anti-C1q Autoantibodies in Lupus Nephritis: Prevalence and Clinical Significance

Anti-Endothelial Cell Antibodies Determination by Cyto-ELISA: A Comparative Study between Three Cell Types Used as Substrates: Nabil Sakly

Prevalence of IgG Anti--Fodrin Antibodies in Sj?gren's Syndrome

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