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9781613243978

Autoimmunity to Neuronal Proteins in Neurological Disorders

by
  • ISBN13:

    9781613243978

  • ISBN10:

    1613243979

  • Edition: 1st
  • Format: Paperback
  • Copyright: 2011-07-01
  • Publisher: NOVA SCIENCE PUBLISHERS INC
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List Price: $59.00

Summary

The brain is often thought of as an immune-privilege site, implying that trafficking of immune cells and molecules into the central nervous system is limited or controlled so as to prevent collateral damage. Nevertheless, there is increasing evidence demonstrating complex interactions between the immune system and the nervous systems. The increasing evidence for the role of auto-immunity to neuronal proteins in both peripheral and central nervous system disorders has led to the development of animal models and in vitro systems to probe human disorders. This book reviews evidence for auto-immunity to neurons and axons in neurological diseases, discusses the animal models that are used to study the mechanisms of disease and indicates how such auto-immunity is relevant for therapies in these disorders

Table of Contents

Preface
Neurons & Axons as Targets of the Immune Response
Disorders of the Neuromuscular Junction
Immune-Mediated Peripheral Neuropathies
Paraneoplastic Neurological Disorders
Movement Disorders
Amyotrophic Lateral Sclerosis & Alzheimer's Disease
Other Neurological Disorders
Multiple Sclerosis
Mechanisms of Immune-Mediated Neurological Damage
Perspectives for Therapy
Index
Table of Contents provided by Publisher. All Rights Reserved.

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