Autoimmunity, Part A Basic Principles and New Diagnostic Tools, Volume 1109

by Gershwin, M. Eric; Shoenfeld, Yehuda

• ISBN13: 9781573316637
• ISBN10: 1573316636
• Edition: 1st
• Format: Paperback
• Copyright: 2007-09-04
• Publisher: Wiley-Blackwell

Summary

The incidence of autoimmune diseases is increasing worldwide, and the search for better management of these diseases and even for a cure is being pursued by scientists from many disciplines. Tools from the areas of genetics, neuroscience, cell biology, virology, and infectious disease are being applied to the problem and are yielding useful results.This volume contains the first section of the proceedings of a large, comprehensive meeting held in Sorrento, Italy. Because the meeting focused on such an important area of human health, four volumes have been dedicated to it: Part A presents new principles in autoimmunity, including the roles of key players such as designed ankyrin repeat proteins, SLAM-associated protein, interleukin-12, human proteinase 3, the complement system, IgG, disturbances in cytokine synthesis, and IFN-γ blockers. The second section of the volume takes a look at new diagnostic tools, including screening of endothelial expression libraries, electrical skin impedance, and IgA anti-tissue transglutaminase antibody assays.Autoimmunity, Part B continues the presentation of basic research and its applications with a focus on genetics. Parts C and D present the clinical research in various manifestations of autoimmune disease and its treatments.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Author Biography

M. Eric Gershwin is the editor of Autoimmunity, Part A: Basic Principles and New Diagnostic Tools, Volume 1109, published by Wiley. Yehuda Shoenfeld is an Israeli physician and autoimmunity researcher.

Table of Contents

Foreword

New Principles of Autoimmunity

The Nature and Nurture of Common Autoimmunity

Designed Ankyrin Repeat Proteins as Anti-Idiotypic Binding Molecules

SLAM-Associated Protein (SAP) Solves a Mystery of Autoimmunity

Standardization of Autoimmune Diagnostics in Germany - Activities of the German Group in the European Autoimmune Standardisation Initiative

Autoimmunity and Time Entanglement

The Pro- and Anti-Inflammatory Potential of Interleukin-12

NKG2D and Natural Cytotoxicity Receptors Are Involved in Natural Killer Cell Interaction with Self-Antigen Presenting Cells and Stromal Cells

The Role of Toll-Like Receptors in HMGB1 Release from Macrophages

Immune Complex Pathophysiology

Human Proteinase 3 (PR3) and Its Binding Molecules: Implications for Inflammatory and PR3-Related Autoimmune Responses

Loss of Self-Control in the Complement System and Innate Autoreactivity

Immunodeficiency and Autoimmune Phenomena in Female Hyper IgM Syndrome (HIGM)

Autoimmune Diseases of Domestic Animals

Prediction and Prevention of Autoimmune Disease: A Personal Perspective

Alterations of Th1/Th2 Reactivity by Heavy Metals: Possible Consequences Include Induction of Autoimmune Diseases

EASI - The European Autoimmunity Standardisation Initiative: A New Initiative That Can Contribute to Agreed Diagnostic Models of Diagnosing Autoimmune Disorders Throughout Europe

Effector Memory CD8+ T Cells Are Resistant to Apoptosis

Two-Step Mechanism of Virus-Induced Autoimmune Hemolytic Anemia

Autoimmune Reactions After Electro-Oxidation of IgG from Healthy Persons

Relevance of Electric Current and Antioxidants

Autoimmune Diseases Are Connected With Disturbances In Cytokine Synthesis and Therapy With IFN-g Blockers Is Their Main Pathogenetic Treatment

New Tools in Diagnosis

Screening of Endothelial Expression Libraries for the Identification of Novel Autoantigens Involved in Distinct Autoimmune Diseases Characterized by Endothelial Dysfunction

Diagnosing Diseases by Mesurement of Electrical Skin Impedance: A Novel Technique

Antigen Preparation for Immunological Studies in Systemic Autoimmune Diseases

Comparison of Two Elisa Assays for Anti-SP100 Determination

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