Basic And Clinical Aspects of Neuroendocrine Immunology in Rheumatic Diseases

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  • Edition: 1st
  • Format: Paperback
  • Copyright: 2006-07-11
  • Publisher: Wiley-Blackwell
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Neuroimmunoendocrine aspects of the pathophysiology of rheumatic diseases are presented in this volume, and new approaches to diagnosis and therapeutic intervention are suggested.Topics presented include gene polymorphisms and the neuroendocrine immune system in rheumatic diseases, anti-TNF strategies and effects on neuroendocrine immune mechanisms in rheumatic diseases, new perspectives on therapeutic use of glucocorticoids, nerve fibers and rheumatoid arthritis, stimulation tests of the stress axes, and sex hormones and lipid metabolism in rheumatic diseases.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Table of Contents

Overview Article for Basic and Clinical Aspects of Neuroendocrine Immunology in Rheumatic Diseases xiii
Robert G. Lahita
Neuroendocrine Immune System Involvement in Rheumatology xviii
Johannes W.J. Bijlsma
Alfonse Masi
Rainer H. Straub
Robert Lahita
Maurizio Cutolo
Part I. The Role of Genetics: Gene Polymorphisms and the Neuroendocrine Immune System in Rheumatic Diseases
The Physiology of Human Glucocorticoid Receptor β (hGRβ) and Glucocorticoid Resistance
Laura J. Lewis-Tuffin
John A. Cidlowski
Angiotensin-Converting Enzyme in Systemic Sclerosis: From Endothelial Injury to a Genetic Polymorphism
Serena Guiducci
Cinzia Fatini
Veronica Rogai
Marina Cinelli
Elena Sticchi
Rosanna Abbate
Marco Matucci Cerinic
Sequence Variants of the CRH 5'-Flanking Region: Effects on DNA-Protein Interactions Studied by EMSA in PC12 Cells
Uta Wagner
Matthias Wahle
Olga Malysheva
Ulf Wagner
Holm Hantzschel
Christoph Baerwald
Genetic Variation in the Endothelin System: Do Polymorphisms Affect the Therapeutic Strategies?
Gian Paolo Rossi
Gisella Pitter
Part II. The Central Nervous System: Stimulation Tests of the Stress Axis and Its Involvement in Rheumatic Diseases
Stress in Autoimmune Disease Models
M.S. Harbuz
L.J. Richards
A.J. Chover-Gonzalez
O. Marti-Sistac
D.S. Jessop
Stress System Activity, Innate and T Helper Cytokines, and Susceptibility to Immune-Related Diseases
Emanuele Calcagni
Ilia Elenkov
The Impact of Stressors on Health Status and Hypothalamic-Pituitary-Adrenal Axis and Autonomic Nervous System Responsiveness in Rheumatoid Arthritis
Rinie Geenen
Henriet Van Middendorp
Johannes W.J. Bijlsma
Hypoglycemia, an Old Tool for New Findings in the Adrenomedullary Hormonal System in Patients with Rheumatic Diseases
Richard Imrich
Increased Neural Sympathetic Activation in Fibromyalgia Syndrome
Piercarlo Sarzi-Puttini
Fabiola Atzeni
Alessandro Diana
Andrea Doria
Raffaello Furlan
Anti-Endothelial Antibodies and Neuropsychiatric Systemic Lupus Erythematosus
Guido Valesini
Cristiano Alessandri
Domenico Celestino
Fabrizio Conti
Neuroendocrine-Immune Interactions: The Role of Cortistatin/Somatostatin System
Diego Ferone
Mara Boschetti
Eugenia Resmini
Massimo Giusti
Valeria Albanese
Umberto Goglia
Manuela Albertelli
Lara Vera
Federico Bianchi
Francesco Minuto
Prolactin and Growth Hormone Responses to Hypoglycemia in Patients with Systemic Sclerosis and Psoriatic Arthritis
Jozef Rovensky
Helena Raffayova
Richard Imrich
Zofia Radikova
Adela Penesova
Ladislav Macho
Jozef Lukac
Marco Matucci-Cerinic
Milan Vigas
Part III. The Peripheral Nervous System: Nerve Fibers, Neuropeptides, and Clinical Links in Arthritis
Innervation of the Joint and Role of Neuropeptides
Yrjo T. Konttinen
Veli-Matti Tiainen
Enrique Gomez-Barrena
Mika Hukkanen
Jari Salo
Neurogenic Inflammation and Arthritis
Jon D. Levine
Sachia G. Khasar
Paul G. Green
Effects of Testosterone, 17β-Estradiol, and Downstream Estrogens on Cytokine Secretion from Human Leukocytes in the Presence and Absence of Cortisol
David Janele
Thomas Lang
Silvia Capellino
Maurizio Cutolo
Jose Antonio P. Da Silva
Rainer H. Straub
Microsomal Prostaglandin E Synthase-I, Ephrins, and Ephrin Kinases as Suspected Therapeutic Targets in Arthritis: Exposed by ``Criminal Profiling.''
Andrej A. Romanovsky
Andrei I. Ivanov
Scott R. Petersen
Sympathetic Nervous System Influence on the Innate Immune Response
Georges J.M. Maestroni
Alexithymia and Neuroendocrine-Immune Response in Patients with Autoimmune Diseases: Preliminary Results on Relationship between Alexithymic Construct and TNF-α Levels
R. Bruni
F.M. Serino
S. Galluzzo
G. Coppolino
F. Cacciapaglia
M. Vadacca
S. Nilo
N. Terminio
A. Afeltra
Part IV. The Role of Gonadal Hormones: Sex Hormones and Rheumatic Diseases
Epidemiological Aspects of Rheumatoid Arthritis: The Sex Ratio
Tore K. Kvien
Till Uhlig
Sigrid Ødegard
Marte S. Heiberg
Sex Hormones and Risks of Rheumatoid Arthritis and Developmental or Environmental Influences
Alfonse T. Masi
Jean C. Aldag
Robert T. Chatterton
Inflammation and Sex Hormone Metabolism
Martin Schmidt
Heidrun Naumann
Claudia Weidler
Martina Schellenberg
Sven Anders
Rainer H. Straub
Estrogens in Pregnancy and Systemic Lupus Erythematosus
Andrea Doria
Luca Iaccarino
Piercarlo Sarzi-Puttini
Anna Ghirardello
Sandra Zampieri
Silvia Arienti
Maurizio Cutolo
Silvano Todesco
Androgen and Prolactin (Prl) Levels in Systemic Sclerosis (SSc): Relationship to Disease Severity
Luisa Mirone
Angela Barini
Antonella Barini
Role of Estrogens in Inflammatory Response: Expression of Estrogen Receptors in Peritoneal Fluid Macrophages from Endometriosis
Silvia Capellino
Paola Montagna
Barbara Villaggio
Alberto Sulli
Stefano Soldano
Simone Ferrero
Valentino Remorgida
Maurizio Cutolo
Part V. Glucocorticoids as Endogenous Neuroendocrine Immune Modulators: New Perspectives in the Therapy of Rheumatic Diseases
Are Glucocorticoids DMARDs?
Johannes W.J. Bijlsma
Jos N. Hoes
Amalia A. Van Everdingen
Suzan M.M. Verstappen
Johannes W.G. Jacobs
Revisiting the Toxicity of Low-Dose Glucocorticoids: Risks and Fears
Jose A. P. Da Silva
Johannes W. G. Jacobs
Johannes W. J. Bijlsma
Circadian Rhythms: Glucocorticoids and Arthritis
Maurizio Cutolo
Alberto Sulli
Carmen Pizzorni
Maria Elena Secchi
Stefano Soldano
Bruno Seriolo
Rainer H. Straub
Kati Otsa
Georges J. Maestroni
Oral Pulsed Dexamethasone Therapy in Early Rheumatoid Arthritis: A Pilot Study
Eric-Jan A. Kroot
A. Margriet Huisman
Jende Van Zeben
Jacques M.G.W. Wouters
Henk C. Van Paassen
Glucocorticoid Effects on Adrenal Steroids and Cytokine Responsiveness in Polymyalgia Rheumatica and Elderly Onset Rheumatoid Arthritis
Alberto Sulli
Carlo Maurizio Montecucco
Roberto Caporali
Lorenzo Cavagna
Paola Montagna
Silvia Capellino
Laura Fazzuoli
Bruno Seriolo
Calvia Alessandro
Maria Elena Secchi
Maurizio Cutolo
Is the Course of Steroid-Treated Polymyalgia Rheumatica More Severe in Women?
Marco A. Cimmino
Massimiliano Parodi
Roberto Caporali
Carlomaurizio Montecucco
Part VI. Clinical Aspects: The Neuroendocrine and Immune Systems in Rheumatology
Predicting and Preventing Autoimmunity, Myth or Reality?
Michal Harel
Yehuda Shoenfeld
Autoimmunity and Pregnancy: Autoantibodies and Pregnancy in Rheumatic Diseases
Angela Tincani
Monica Nuzzo
Mario Motta
Sonia Zatti
Andrea Lojacono
David Faden
Cytokines and Pregnancy in Rheumatic Disease
Monika Østensen
Frauke Forger
Peter M. Villiger
Anti-Beta-2 Glycoprotein I Antibodies Affect Bcl-2 and Bax Trophoblast Expression without Evidence of Apoptosis
Nicoletta Di Simone
Roberta Castellani
Elena Raschi
M. Orietta Borghi
Pier Luigi Meroni
Alessandro Caruso
Endocrine Regulation of Suppressor Lymphocytes: Role of the Glucocorticoid-Induced TNF-Like Receptor
Simone Negrini
Daniela Fenoglio
Piercesare Balestra
Marco Fravega
Gilberto Filaci
Francesco Indiveri
Neuroendocrine Manifestations of Phospholipid Antibody Disease Identified by Long-Term Follow-Up Study of Patients with Phospholipid Antibodies
William Traverse
Beatriz Tendler
Charles Galea
Santhanan Lakshminarayan
Ann Parke
Part VII. Clinical Evidence: Anti-TNF Strategies and Effects on Neuroendocrine Immune Mechanisms in Rheumatic Diseases
Anti-TNF and Sex Hormones
Maurizio Cutolo
Alberto Sulli
Silvia Capellino
Barbara Villaggio
Paola Montagna
Carmen Pizzorni
Sabrina Paolino
Bruno Seriolo
Lamberto Felli
Rainer H. Straub
DHEA Metabolism in Arthritis: A Role for the p450 Enzyme Cyp7b at the Immune-Endocrine Crossroad
John Dulos
Annemieke H. Boots
Effects of Anti-TNF-α Treatment on Lipid Profile in Patients with Active Rheumatoid Arthritis
Bruno Seriolo
Sabrina Paolino
Alberto Sulli
Daniela Fasciolo
Maurizio Cutolo
Bone Metabolism Changes During Anti-TNF-α Therapy in Patients with Active Rheumatoid Arthritis
Bruno Seriolo
Sabrina Paolino
Alberto Sulli
Valentino Ferretti
Maurizio Cutolo
Neuroendocrine Modulation Induced by Selective Blockade of TNF-α in Rheumatoid Arthritis
Gabriele Di Comite
Alessandro Marinosci
Paola Di Matteo
Angelo Manfredi
Rovere-Querini Patrizia
Elena Baldissera
Patrizia Aiello
Angelo Corti
Maria Grazia Sabbadini
Nerve Growth Factor and Brain-Derived Neurotrophic Factor Levels in Patients with Rheumatoid Arthritis Treated with TNF-α Blockers
Flavia Del Porto
Luigi Aloe
Bruno Lagana
Viviana Triaca
Italo Nofroni
Raffaele D'amelio
Part VIII. Clinical Perspectives: Lipid Metabolism in Rheumatic Diseases
Adipose Tissue Has Anti-Inflammatory Properties: Focus on IL-1 Receptor Antagonist (IL-IRa)
Jean-Michel Dayer
Rachel Chicheportiche
Cristiana Juge-Aubry
Christoph Meier
Leptin Is a Link between Adipose Tissue and Inflammation
Peter Harle
Rainer H. Straub
Induction of Neutrophil Chemotaxis by Leptin: Crucial Role for p38 and Src Kinases
Fabrizio Montecucco
Giordano Bianchi
Paola Gnerre
Maria Bertolotto
Franco Dallegri
Luciano Ottonello
Part IX. Metabolic/Inflammatory Effects
Cell Stress Response in Skeletal Muscle Myofibers
Elena Tarricone
Anna Ghirardello
Sandra Zampieri
Rampudda Maria Elisa
Andrea Doria
Luisa Gorza
Impact of Thiopurine Methyltransferase Activity and 6-Thioguanine Nucleotide Concentrations in Patients with Chronic Inflammatory Diseases
Jorg Schedel
Andrea Godde
Ekkehard Schutz
Tim A. Bongartz
Bernhard Lang
Jurgen Scholmerich
Ulf Muller-Ladner
Index of Contributors 493

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