Basic Clinical Radiobiology

by Steel, G. Gordon

• ISBN13: 9780340807835
• ISBN10: 0340807830
• Edition: 3rd
• Format: Hardcover
• Copyright: 2002-09-26
• Publisher: Hodder Education Publishers

Summary

This concise, but comprehensive textbook sets out all the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology. The fully updated 3rd edition continues to discuss the basis of radiation therapy and presents the principles andsignificant scientific developments that underlie current attempts to improve the radiotherapeutic management of all cancers. New topics in the 3rd edition include chapters on volume effects in normal tissues and the L-Q approach in clinical practice, with major revisions to sections on cell proliferation, radiation cytogenetics, radiotherapy-related morbidity, hyperfractionation and individualization of radiotherapy. Thebook continues to provide invaluable advice for residents and practicing radiation oncologists from a team of internationally respected contributors and draws on the considerable experience of the Editor, gained during his time as Course Director of the annual ESTRO course in Basic ClinicalRadiobiology. Key Features: * Builds on the success and reputation of previous successful editions * The gold standard European text for training in this subject, adopted by ESTRO as a course book * Restructured and new chapters incorporated to bring the text in line with all recentdevelopments * Continues to adopt a clear and concise style, appropriate for residents and also practicing radiation oncologists requiring a ready reference to the subject * Draws on the considerable teaching experience of an international author team * Highly illustrated to improveunderstanding

Author Biography

G. Gordon Steel is Emeritus Professor of Radiobiology Applied to Radiotherapy, Department of Radiotherapy Research, The Institute of Cancer Research, Sutton, Surrey, UK.

Table of Contents

List of contributors	vii
Preface	ix
Introduction: the significance of radiobiology for radiotherapy	1	(7)
GG Steel
Cell proliferation and growth rate of tumours	8	(15)
AC Begg
GG Steel
Proliferative and cellular organization of normal tissues	23	(7)
FA Stewart
AJ van der Kogel
Radiation response and tolerance of normal tissues	30	(12)
AJ van der Kogel
Volume effects in normal tissues	42	(10)
FA Stewart
AJ van der Kogel
Cell servival as a determinant of tumour response	52	(12)
GG Steel
Models of radiation cell killing	64	(7)
MC Joiner
DNA damage and cell killing	71	(13)
TJ McMillan
GG Steel
Genetic control of the cellular response to ionizing readiation	84	(10)
TJ McMillan
AC Begg
Dose--response relationships in radiotherapy	94	(11)
SM Bentzen
Clinical manifestations of normal-tissue damage	105	(15)
M Baumann
SM Bentzen
Time-dose relationships: the linear-quadratic approach	120	(14)
MC Joiner
SM Bentzen
The linear-quadratic model in clinical practice	134	(13)
SM Bentzen
M Baumann
Modified fractionation	147	(11)
M Baumann
MI Saunders
MC Joiner
The oxygen effect and tumour microenvironment	158	(11)
MR Horsman
J Overgaard
Overcoming tumour radioresistance resulting from hypoxia	169	(13)
MR Horsman
J Overgaard
The radiobiology of tumours	182	(10)
GG Steel
The dose rate effect: brachytherapy and targeted radiotherapy	192	(13)
GG Steel
Particle beams in radiotherapy	205	(12)
MC Joiner
The combination of radiotherapy and chemotherapy	217	(14)
FA Stewart
H Bartelink
Retreatment tolerance of normal tissues	231	(10)
FA Stewart
Individualization of therapy	241	(12)
AC Begg
CML West
Glossary	253	(5)
Index	258