Basic Immunology : The Functions and Disorders of the Immune System

by Abbas, Abul K.; Lichtman, Andrew H.

• ISBN13: 9780721602417
• ISBN10: 072160241X
• Edition: 2nd
• Format: Paperback
• Copyright: 2004-01-01
• Publisher: Elsevier Science Health Science div

Summary

The 2nd edition of this popular text emphasizes the fundamental concepts and principles of human immunology that students need to know, without overwhelming them with extraneous material. It leads the reader to a firm understanding of basic principles, using full-color illustrations; short, easy-to-read chapters; color tables that summarize key information clinical cases; and much more-all in a conveniently sized volume that's easy to carry. The New Edition has been thoroughly updated to reflect the many advances that are expanding our understanding of the field. Presents all of the most important principles that govern the function of the immune system. Extrapolates key concepts from the vast amount of experimental data that has emerged. Focuses on cellular interactions in immune responses rather than describing in detail many of the underlying biochemical and molecular mechanisms. Emphasizes immune responses in human rather than experimental animals, drawing upon parallels with experimental situations only when necessary. Uses clear, crisp illustrations, diagrams, figures, charts and tables to highlight important principles. Illustrates how the principles of immunology may be applied to common human diseases through clinical cases in the Appendix. Features an easy-to-read layout; summarizes chapter content in bulleted lists accompanied by review questions; and offers a list of selected readings. all of the scientific advances that are expanding the knowledge base in this rapidly evolving field.

Author Biography

Abul K. Abbas, MBBS: Professor and Chair University of California, San Francisco, School of Medicine Andrew H. Lichtman, MD, PhD: Harvard Medical School; Brigham and Women's Hospital, Boston, Massachusetts

Table of Contents

Introduction to the Immune System: The Nomenclature, General Properties, and Components of the Immune System	p. 1
Innate Immunity: The Early Defense Against Infections	p. 21
Antigen Capture and Presentation to Lymphocytes: What Lymphocytes See	p. 41
Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and the Development of Immune Repertoires	p. 63
Cell-Mediated Immune Responses: Activation of T Lymphocytes by Cell-Associated Microbes	p. 83
Effector Mechanisms of Cell-Mediated Immunity: Eradication of Intracellular Microbes	p. 105
Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies	p. 123
Effector Mechanisms of Humoral Immunity: The Elimination of Extracellular Microbes and Toxins	p. 143
Immunologic Tolerance and Autoimmunity: Self-Nonself Discrimination in the Immune System and Its Failure	p. 161
Immune Responses Against Tumors and Transplants: Immunity to Noninfectious Transformed and Foreign Cells	p. 177
Hypersensitivity Diseases: Disorders Caused by Immune Responses	p. 193
Congenital and Acquired Immunodeficiencies: Diseases Caused by Defective Immune Responses	p. 209
Suggested Readings	p. 225
Principal Features of CD Molecules	p. 229
Glossary	p. 263
Clinical Cases	p. 291
Index	p. 301
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