Berries and Cancer Prevention

by Stoner, Gary D.; Seeram, Navindra P.

• ISBN13: 9781441975539
• ISBN10: 1441975535
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-12-30
• Publisher: Springer Verlag

Summary

Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.

Table of Contents

Berry Composition, Bioavailability, Metabolism and Biological Effects
Contribution of Berry Anthocyanins to Their Chemopreventive Properties	p. 3
Ursolic Acid and Other Pentacyclic Triterpenoids: Anticancer Activities and Occurrence in Berries	p. 41
The Effects of Berry Extracts on Cell Signaling Pathways: Leading to Cellular Transformation	p. 51
Antioxidant Capacity of Berry Components
Correlation of Antioxidants and Antioxidant Enzymes to Oxygen Radical Scavenging Activities in Berries	p. 79
Chemopreventive Effects of Berries and Berry Components in Animal Model Systems
Berries in the Prevention of Esophageal Adenocarcinoma	p. 101
Endothelial Cell Tumor Prevention with Berry Extracts: Clinical Problems, Molecular Mechanisms and Therapeutic Opportunities	p. 117
Effects of Black Raspberries on UV-Induced Cutaneous Inflammation and Tumor Development	p. 131
Chemopreventive Effects of Berries and Berry Components in the Rodent Esophagus	p. 143
Chemopreventive Effects of Berries and Berry Components in Animal Models: Prevention of Estrogen-Mediated Mammary Tumors in ACI Rats by Berries	p. 163
Inhibition of Oral Cancer in Animal Models by Black Raspberries and Berry Components	p. 189
Prevention of Cancer with Pomegranate and Pomegranate Anthocyanins	p. 209
Chemoprevention of Chronic Inflammatory Bowel Disease-Induced Carcinogenesis in Rodent Models by Berries	p. 227
Berry Chemoprevention in High-Risk Populations
Cancer Prevention in Humans at High-Risk for Development of Cancer: Prevention of Oral Dysplasia in Humans by Berry Formulations	p. 247
Cancer Prevention in Populations High At-Risk for the Development of Oral Cancer: Clinical Trials with Black Raspberries	p. 259
Effects of Black Raspberries on Cellular and Epigenetic Biomarkers of Colon Cancer Development in Humans	p. 281
Index	p. 305
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