Beyond the Synapse: Cell-Cell Signaling in Synaptic Plasticity

by Edited by R. Douglas Fields

• ISBN13: 9780521869140
• ISBN10: 0521869145
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-09-15
• Publisher: Cambridge University Press

Summary

Formation of synapses and the changes in their connections during life are the basis for learning and memory and recovery from brain disease or injury. Much interest has been focused on how synapses function at the molecular level, while the cell-cell interactions controlling the formation receive far less attention. This book expands the scope of inquiry beyond the synaptic cleft to provide a comprehensive insight into how intercellular signalling enables neurons to communicate beyond the synapse, and to interact with other cells in the brain to alter synaptic connections appropriately. There are chapters devoted to consideration of glia, brain cells which have thus far been ignored in the majority of studies of learning and memory. Writing for academic researchers and professionals, contributors to this book reveal that there is much to learning and memory that lies beyond the synapse.

Table of Contents

List of contributors	p. vii
Introduction: Beyond the synapse	p. 1
Spanning Scales of Neural Plasticity	p. 5
Memory beyond the synapse	p. 7
Between synapses and behavior: functional circuitry of the hippocampus	p. 14
Widening the lens: looking beyond the synapse for experience-driven brain plasticity	p. 22
Activity-dependent myelination	p. 36
Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses	p. 43
Novelty, Stress, and Hormones in Plasticity	p. 57
Sleep-dependent memory consolidation and reconsolidation	p. 59
Consolidation and reconsolidation of Pavlovian fear-conditioning: roles for intracellular signaling and extracellular modulation in memory storage	p. 72
Emotional and cognitive reinforcement of rat hippocampal long-term potentiation by different learning paradigms	p. 89
Estrogen and hippocampal synaptic plasticity	p. 97
Steroid-induced hippocampal synaptic plasticity: sex differences and similarities	p. 111
Cell-Cell Signaling Molecules in Synaptic Plasticity	p. 121
MHC class I in activity-dependent structural and functional plasticity	p. 123
Cytokine induction of neuronal receptor trafficking: relevance to synaptic function and excitotoxicity	p. 130
Neurotrophin signaling among neurons and glia during formation of synapses	p. 142
Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory	p. 153
Focal adhesion-like processes underlie induction of long-term potentiation in the Schaffer collateral-CA1 region of the hippocampus	p. 160
Signaling to the nucleus in long-term memory	p. 169
Non-Traditional Transmitters and Glia
Diffusible hydrogen peroxide generated by synaptic activity inhibits axonal dopamine release in striatum	p. 181
D-serine as a putative glial neurotransmitter	p. 193
A dialogue between glia and neurons in the retina: modulation of neuronal excitability	p. 201
Metabotropic glutamate receptors as a target for astrocytic control of inhibitory synaptic transmission in the hippocampus	p. 210
References	p. 219
Index	p. 304
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