Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

by Mathiowitz; Edith

• ISBN13: 9780824719951
• ISBN10: 0824719956
• Edition: 1st
• Format: Hardcover
• Copyright: 1999-07-13
• Publisher: CRC Press

Summary

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs. Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport! Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles describes vaginal, nasal, buccal, ocular, and transdermal drug delivery reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts explores issues of product development, clinical testing, and production and more! Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologists; chemical, polymer, and plastics engineers; biochemists; physical, surface, and colloid chemists; biologists; and upper-level undergraduate and graduate students in these disciplines.

Table of Contents

Preface	iii
Contributors	xi
I. Fundamentals of Bioadhesion
Definitions, Mechanisms, and Theories of Bioadhesion	1	(10)
Donald E. Chickering III
Edith Mathiowitz
The Role of Water Movement and Polymer Hydration in Mucoadhesion	11	(14)
John D. Smart
A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels	25	(42)
Carla Marcella Caramella
Silvia Rossi
Maria Cristina Bonferoni
Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina	67	(18)
Udo Schumacher
Dietlind Schumacher
Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins	85	(46)
Barry James Campbell
II. Methods of Evaluating Bioadhesive Interactions
Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres	131	(16)
Donald E. Chickering III
Camilla A. Santos
Edith Mathiowitz
Novel Magnetic Technique to Measure Bioadhesion	147	(28)
Benjamin A. Hertzog
Edith Mathiowitz
Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems	175	(22)
Michael Horstmann
Walter Muller
Bodo Asmussen
Force Microscopy of Cells to Measure Bioadhesion	197	(26)
E. zur Muhlen
P. Koschinski
S. Gehring
Robert Ros
Louis Tiefenhauer
Eleonore Haltner
Claus-Michael Lehr
Uwe Hartmann
Falk Schwesinger
A. Pluckthun
Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems	223	(38)
James Schneider
Matthew Tirrell
A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction	261	(38)
Cheng Zhu
James W. Piper
Robert A. Swerlick
III. Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems
Multifunctional Polymers for the Peroral Delivery of Peptide Drugs	299	(42)
Henrik L. Luessen
J. Coos Verhoef
A. (Bert) G. de Boer
H. E. Junginger
Bas J. de Leeuw
Gerrit Borchard
Claus-Michael Lehr
Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia	341	(46)
A. F. Kotze
Henrik L. Luessen
M. Thanou
J. Coos Verhoef
A. (Bert) G. de Boer
H. E. Junginger
Claus-Michael Lehr
Plant Lectins for Oral Drug Delivery to Different Parts of the Gastrointestinal Tract	387	(22)
Arpad Pusztai
Susan Bardocz
Stanley W. B. Ewen
Bacterial Invasion Factors and Lectins as Second-Generation Bioadhesives	409	(24)
James H. Easson
Eleonore Haltner
Claus-Michael Lehr
Dieter Jahn
Novel PEG-Containing Acrylate Copolymers with Improved Mucoadhesive Properties	433	(26)
Amir H. Shojaei
Xiaoling Li
Bioadhesive, Bioerodible Polymers for Increased Intestinal Uptake	459	(18)
Gerardo P. Carino
Jules S. Jacob
C. James Chen
Camilla A. Santos
Benjamin A. Hertzog
Edith Mathiowitz
IV. Development Issues of Bioadhesive Drug Delivery Systems: Products and Clinical Trials
Novel Formulation Approaches to Oral Mucoadhesive Drug Delivery Systems	477	(30)
Yohko Akiyama
Naoki Nagahara
Bioadhesive Formulations for Nasal Peptide Delivery	507	(34)
Lisbeth Illum
Development of Bioadhesive Buccal Patches	541	(22)
Jian-Hwa Guo
Karsten Cremer
Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations	563	(38)
Julie L. Richardson
Trevor I. Armstrong
Ocular Bioadhesive Drug Delivery Systems	601	(40)
Marco Fabrizio Saettone
Susi Burgalassi
Patrizia Chetoni
Bioadhesive Preparations as Topical Dosage Forms	641	(18)
Yoshiharu Machida
Tsuneji Nagai
Index	659