Biocatalysis for the Pharmaceutical Industry Discovery, Development, and Manufacturing

by Tao, Junhua (Alex); Lin, Guo-Qiang; Liese, Andreas

• ISBN13: 9780470823149
• ISBN10: 0470823143
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-10-31
• Publisher: Wiley

Summary

Taking the latest breakthroughs in genomics and proteomics into consideration, the present book discusses modern application of biocatalysis in drug discovery, development and manufacturing. A concise but comprehensive approach is used to cover enzyme discovery, applications of enzymatic transformations for development of pharmaceutically active compounds, biocatalysis in synthesizing, screening, identifying and characterizing human drug metabolites, combinatorial biosynthesis of active natural products for drug discovery, application of metabolic engineering, optimization of production hosts for efficient development of biopharmaceuticals and applying biocatalysis for the development of green chemistry. Each chapter is written by leading experts in respective fields. Concise yet comprehensive and systematic discussion with latest developments in genomics and proteomics. Coverage on emerging fields such as metabolic engineering, combinatorial biosysnthesis and green chemistry Up-to-date integrated with latest developments in genomics and proteomics Concise but comprehensive, systematic and practical

Author Biography

Dr. Junhua Tao is co-founder and Chief Scientific Officer at BioVerdant, Inc.USA. He was the Head of the Biotransformation Group at Pfizer Global R&D from 2000 to 2005. Trained in synthetic organic chemistry, Dr. Tao has published over 50 papers and serve as an advisory board member of Engineering in Life Sciences

Prof. Guo-Qiang Lin is a professor at Shanghai Institute of Organic Chemistry, the Chinese Academy of Sciences, China. With over 150 publications, Prof. Lin is well recognized in synthetic organic chemistry and medicinal chemistry. He is associate editors for three journals in the fields and an Executive Board Member for Tetrahedron.

Prof. Andreas Liese is Professor of Technical Biochemistry and Head of Institute of Technical Biocatalysis, Hamburg University of Technology, Germany. Worked in both academia and pharmaceutical industry, Prof. Liese has made significant contributions to industrial biotransformations, enzyme technology and biochemical engineering. He is a member of the editorial board, Journal of Molecular Catalysis B and has published over 50 papers and 2 books.

Table of Contents

Preface

Enzyme discovery, development and manufacturing

Enzyme directed evolution and high throughput screening

Retrosynthetic biotransformations and applications of reaction engineering

Practical synthesis of pharmaceutical intermediates using hydrolases

Synthetic applications of ketoreductases and alcohol oxidases

Applications of glycosyltransferases for drug discovery and development

Enantioselective synthesis by aldolases, amine oxidases, transaminases and oxynitrilases

Biosynthesis of drug metabolites for drug discovery

Metabolic engineering for development and manufacturing of pharmaceuticals

Combinatorial biosynthesis of pharmaceutical natural products and modification

Biopharmaceutical and enzyme production: expression and host optimization

Biocatalysis and green chemistry development of pharmaceuticals

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