Biocatalysis for the Pharmaceutical Industry : Discovery, Development, and Manufacturing

by Junhua Tao (BioVerdant, Inc. USA); Guo-Qiang Lin (Shanghai Institute of Organic Chemistry, China); Andreas Liese (Forschungszentrum Julich, Germany)

• ISBN13: 9780470823156
• ISBN10: 0470823151
• Format: eBook
• Copyright: 2009-07-01
• Publisher: Wiley

Summary

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field.Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniquesBiocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Table of Contents

Enzymes and Their Synthetic Applications: An Overview

Expression hosts for enzyme discovery and production

Directed Enzyme Evolution and High Throughput Screening

Applications of reaction engineering to industrial biotransformations

Chiral synthesis of pharmaceutical intermediates using oxynitrilases

Expanding the Scope of Aldolases as Tools for Organic Synthesis

Synthetic Applications of Ketoreductases and Alcohol Oxidases

Applications of Nitrile Hydratases and Nitrilases

Biosynthesis of drug metabolites

Application of Whole Cell Biotransformation in Pharmaceutical Industry

Combinatorial Biosynthesis of Pharmaceutical Natural Products

Metabolic engineering for the development and manufacturing of pharmaceuticals

Multimodular Synthases and Supporting Enzymes for Chemical Production

Green Chemistry with Biocatalysis for Production of Pharmaceuticals

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