Biochemistry The Molecular Basis of Life

by McKee, Trudy; McKee, James R.

• ISBN13: 9780195305753
• ISBN10: 0195305752
• Edition: 4th
• Format: Hardcover
• Copyright: 2008-04-28
• Publisher: Oxford University Press

Summary

Biochemistry: The Molecular Basis of Life is an intermediate, one-semester text written for students on degree pathways in Chemistry, Biology and other Health and Life Sciences. Aimed at students who have a previous knowledge of organic chemistry, the text focuses on essential biochemicalprinciples that underpin the modern life sciences, and offers the most balanced coverage of chemistry and biology of any text on the market. Biochemistry: The Molecular Basis of Life provides a complete view of the living state by explaining the functional and structural properties of biomoleculesin the context of their biochemical reactions and impact on living organisms. It also places strong emphasis on critical thinking to help students diagnose real biochemical problems, and integrates fascinating applications of Biochemistry to the fields of Health, Agriculture, Engineering andForensics in order to relate concept to experience and show students the relevance of their learning.

Table of Contents

New to this edition

Preface

What Is Life?

The Living World

Bacteria

Archaea

Eukarya

Biomolecules

Functional Groups of Organic Biomolecules

Major Classes of Small Biomolecules

Is the Living Cell a Chemical Factory?

Biochemical Reactions

Energy

Overview of Metabolism

Biological Order

Systems Biology

Emergence

Robustness

Modularity

Biochemistry in the Lab: An Introduction

Summary

Suggested Readings

Key Words

Review Questions

Thought Questions

Living Cells

Basic Themes

Water

Biological Membranes

Self-Assembly

Molecular Machines

Macromolecular Crowding

Signal Transduction

Structure of Prokaryotic Cells

Cell Wall

Plasma Membrane

Cytoplasm

Pili and Flagella

Structure of Eukaryotic Cells

Plasma Membrane

Endoplasmic Reticulum

Golgi Apparatus

Nucleus

Vesicular Organelles

Mitochondria

Peroxisomes

Biochemistry in Perspective: Organelles in Human Disease

Plastids

Cytoskeleton

Ribosomes

Biochemistry in the Lab: Cell Technology

Summary

Suggested Readings

Key Words

Review Questions

Thought Questions

Water: The Matrix Of Life

Molecular Structure of Water

Noncovalent Bonding

Ionic Interactions

Hydrogen Bonds

Van der Waals Forces

Thermal Properties of Water

Solvent Properties of Water

Hydrophilic Molecules

Hydrophobic Molecules and the Hydrophobic Effect

Amphipathic Molecules

Osmotic Pressure

Ionization of Water

Acids, Bases, and pH

Buffers

Physiological Buffers

Biochemistry in Perspective: Water, Abiotic Stress, and Compatible Solutes

Biochemistry in the Lab: Dialysis

Available online

Biochemistry in Perspective: Cell Volume Regulation and Metabolism

Summary

Suggested Readings

Key Words

Review Questions

Thought Questions

Energy

Thermodynamics

The First Law of Thermodynamics

Second Law of Thermodynamics

Free Energy

Standard Free Energy Changes

Coupled Reactions

The Hydrophobic Effect Revisited

Biochemistry in Perspective: Non-Equilibrium Thermodynamics

The Role of ATP

Biochemistry in Perspective: The Extremophiles: Organisms that Make a Living in Hostile Environments

Summary

Suggested Readings

Key Words

Review Questions

Thought Questions

Amino Acids, Peptides, And Proteins

Amino Acids

Amino Acid Classes

Biologically Active Amino Acids

Modified Amino Acids in Proteins

Amino Acid Stereoisomers

Titration of Amino Acids

Amino Acid Reactions

Peptides

Proteins

Protein Structure

Biochemistry in Perspective: Molecular Machines

The Folding Problem

Biochemistry in Perspective: Protein Folding and Human Disease

Fibrous Proteins

Globular Proteins

Biochemistry in the Lab: Protein Technology

Summary

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