Biodefense Research Methodology and Animal Models, Second Edition

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  • Edition: 2nd
  • Format: Hardcover
  • Copyright: 2012-02-16
  • Publisher: CRC Press

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To ensure that efforts to improve our biodefensive capabilities continue in an efficient manner, this volume presents a thorough review of pertinent research, encouraging researchers to leverage relevant results, rather than duplicate them.& With contributions from those who have developed the animal models presented, this book examines bacterial, viral, and toxic agents considered to pose the greatest threat. Each section on a specific agent provides background, followed by a description of those animal models employed, and a discussion of how the findings translate to human impact. New chapters include Brucellosis, Melioidosis, Rickettsials (R. prowazekiiand R. rickettsii), and Abrin toxin. New guidance provided by the FDA on the implementation of the Animal Efficacy Rule are included.

Table of Contents

Prefacep. ix
Editorp. xi
Contributorsp. xiii
History-of Biological Agents as Weaponsp. 1
Bioterrorism and Biowarfare: Similarities and Differencesp. 15
Scientific and Ethical Importance of Animal Models in Biodefense Researchp. 27
Development and Validation of Animal Modelsp. 45
Infectious Disease Aerobiology: Aerosol Challenge Methodsp. 65
Characterization of New and Advancement of Existing Animal Models of Bacillus anthracis Infectionp. 81
Glandersp. 99
Plaguep. 113
Tularemiap. 147
Q Feverp. 179
Brucellosisp. 197
Alphavirusesp. 223
Orthopoxvirusesp. 255
Animal Models for Viral Hemorrhagic Feversp. 271
Botulinum Toxinsp. 311
Ricinp. 333
Staphylococcal and Streptococcal Superantigens: In Vitro and In Vivo Assaysp. 357
Indexp. 391
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