Biodefense Research Methodology and Animal Models, Second Edition

by Swearengen; James R.

• ISBN13: 9781439836323
• ISBN10: 1439836329
• Edition: 2nd
• Format: Hardcover
• Copyright: 2012-02-16
• Publisher: CRC Press

Summary

To ensure that efforts to improve our biodefensive capabilities continue in an efficient manner, this volume presents a thorough review of pertinent research, encouraging researchers to leverage relevant results, rather than duplicate them.& With contributions from those who have developed the animal models presented, this book examines bacterial, viral, and toxic agents considered to pose the greatest threat. Each section on a specific agent provides background, followed by a description of those animal models employed, and a discussion of how the findings translate to human impact. New chapters include Brucellosis, Melioidosis, Rickettsials (R. prowazekiiand R. rickettsii), and Abrin toxin. New guidance provided by the FDA on the implementation of the Animal Efficacy Rule are included.

Table of Contents

Preface	p. ix
Editor	p. xi
Contributors	p. xiii
History-of Biological Agents as Weapons	p. 1
Bioterrorism and Biowarfare: Similarities and Differences	p. 15
Scientific and Ethical Importance of Animal Models in Biodefense Research	p. 27
Development and Validation of Animal Models	p. 45
Infectious Disease Aerobiology: Aerosol Challenge Methods	p. 65
Characterization of New and Advancement of Existing Animal Models of Bacillus anthracis Infection	p. 81
Glanders	p. 99
Plague	p. 113
Tularemia	p. 147
Q Fever	p. 179
Brucellosis	p. 197
Alphaviruses	p. 223
Orthopoxviruses	p. 255
Animal Models for Viral Hemorrhagic Fevers	p. 271
Botulinum Toxins	p. 311
Ricin	p. 333
Staphylococcal and Streptococcal Superantigens: In Vitro and In Vivo Assays	p. 357
Index	p. 391
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