Biodegradable Systems in Tissue Engineering and Regenerative Medicine

by Reis; Rui L.

• ISBN13: 9780849319365
• ISBN10: 0849319366
• Format: Hardcover
• Copyright: 2004-11-29
• Publisher: CRC Press

Summary

Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health care.The most important materials in development for use in tissue engineering, replacement, and regeneration are based on polymers and on composites reinforced with bioactive ceramics. The first book to address the topic in an integrated manner, Biodegradable Systems in Tissue Engineering and Regenerative Medicine presents an extensive description of biodegradable polymers used in medicine and explores their design, development, and processing. The authors discuss the performance of biodegradable systems and the special requirements that should be taken into account when evaluating their biocompatibility. Included are several methodologies for tailoring cell adhesion and proliferation on the surface of biodegradable polymers.This book represents a coordinated effort by outstanding international experts, and provides an integrated, forward-looking perspective. By joining together the most active groups in the field, the editors offer a unified approach, representing diverse fields of study, to produce a revolution in regenerative medicine.

Table of Contents

PART I Processing and Applications of Biodegradable Systems
Biodegradable Polymers in Medicine	3	(10)
Masakazu Suzuki
Yoshito Ikada
Injectable Biodegradable Systems	13	(16)
L. F. Boesel
Rui L. Reis
Injectable Polymeric Scaffolds for Bone Tissue Engineering	29	(10)
Manuela E. Gomes
Rui L. Reis
Antonios G. Mikos
Totally or Partially Biodegradable Self-Polymerizing Composites for Orthopedic Surgery and Dental Applications	39	(14)
Blanca Vazquez
Gustavo A. Abraham
Carlos Elvira
Julio San Roman
Fiber Bonding and Particle Aggregation as Promising Methodologies for the Fabrication of Biodegradable Scaffolds for Hard-Tissue Engineering	53	(14)
Manuela E. Gomes
Patricia B. Malafaya
Rui L. Reis
Design and Fabrication of Scaffolds via Solid Free-Form Fabrication	67	(24)
Dietmar W. Hutmacher
Biodegradable Composites for Biomedical Applications	91	(24)
N. M. Neves
J. F. Mano
Rui L. Reis
Development of Bioactive Composites Based on Biodegradable Systems for Bone Replacement Applications	115	(12)
I. B. Leonor
R. A. Sousa
Rui L. Reis
Mechanical Characterization of Biomaterials	127	(18)
J. F. Mano
N. M. Neves
Rui L. Reis
Chitosan-Based Microcomposites --- From Biodegradable Microparticles to Self-Curing Hydrogels	145	(18)
Alberto Gallardo
Maria Rosa Aguilar
Carlos Elvira
Carlos Peniche
Julio San Roman
Processing and Biomedical Applications of Degradable Polymeric Fibers	163	(14)
K. Tuzlakoglu
Rui L. Reis
Understanding the Enzymatic Degradation of Biodegradable Polymers and Strategies to Control Their Degradation Rate	177	(28)
Helena S. Azevedo
Rui L. Reis
PART II Production of Biomimetic Coatings on the Surface of Degradable Polymers
Bonelike Apatite Coatings Nucleated on Biodegradable Polymers as a Way to Induce Bone Mineralization: Current Developments and Future Trends	205	(18)
A. L. Oliveira
Rui L. Reis
Biomimetic Coatings, Proteins, and Biocatalysts: A New Approach to Tailor the Properties of Biodegradable Polymers	223	(30)
I. B. Leonor
Helena S. Azevedo
Catarina M. Alves
Rui L. Reis
PART III Systems for Controlled Release of Bioactive Agents
Strategies for Delivering Bone and Cartilage Regenerating Factors	253	(28)
Patricia B. Malafaya
Gabriela A. Silva
Rui L. Reis
Resorbable Polymeric Delivery Systems Based on Physical Absorption/Diffusion versus Chemically Controlled Delivery Systems	281	(20)
Julio San Roman
Alberto Gallardo
Carlos Elvira
Blanca Vazquez
Gustavo A. Abraham
Enzyme Immobilization in Biodegradable Polymers for Biomedical Applications	301	(24)
S. A. Costa
Helena S. Azevedo
Rui L. Reis
Use of Chemically Modified Chitosan and Other Natural-Origin Polymers in Tissue Engineering and Drug Delivery	325	(14)
E. T. Baran
Rui L. Reis
PART IV Biocompatibility and Immunological Responses to Degradable Biomaterials
Cytotoxicity Screening of Biodegradable Polymeric Systems	339	(16)
Gabriela A. Silva
A. P. Marques
Manuela E. Gomes
O. P. Coutinho
Rui L. Reis
Natural-Origin Degradable Materials: The Barrier or the Passage through the Immune System?	355	(22)
A. P. Marques
J. A. Hunt
Rui L. Reis
Mediation of the Cytokine Network in the Implantation of Orthopedic Devices	377	(22)
A. P. Marques
J. A. Hunt
Rui L. Reis
Protein and Cell Interactions with Biodegradable Systems	399	(30)
Catarina M. Alves
Rui L. Reis
Surface Activation and Modification --- A Way for Improving the Biocompatibility of Degradable Biomaterials	429	(28)
I. Pashkuleva
Rui L. Reis
PART V Biodegradable Polymers for the Engineering and Regeneration of Different Tissues
Bone and Articular Cartilage Tissue Engineering: The Biological Components	457	(22)
A. J. Salgado
Manuela E. Gomes
O. P. Coutinho
Rui L. Reis
Tissue Engineering of the Liver	479	(14)
Y. Murat Elcin
Smart Biodegradable Hydrogels with Applications in Drug Delivery and Tissue Engineering	493	(16)
Carlos Elvira
Gustavo A. Abraham
Alberto Gallardo
Julio San Roman
Skin Tissue Engineering Part I --- Review	509	(20)
Dietmar W. Hutmacher
K. W. Ng
H. L. Khor
Skin Tissue Engineering Part II --- The In Vitro Evaluation of Natural and Synthetic 3-D Matrices as Dermal Substrates	529	(20)
K. W. Ng
H. L. Khor
Dietmar W. Hutmacher
Biodegradable Polymers for Guided Nerve Regeneration	549	(8)
K. Tuzlakoglu
Rui L. Reis
Index	557