Biofilm Infections

by Bjarnsholt, Thomas; Moser, Claus; Jensen, Peter Ostrup; Hoiby, Niels

• ISBN13: 9781441960832
• ISBN10: 144196083X
• Format: Hardcover
• Copyright: 2010-10-30
• Publisher: Springer Verlag

Summary

This book will cover both the evidence for biofilms in many chronic bacterial infections as well as the problems facing these infections such as diagnostics and treatment regimes. A still increasing interest and emphasis on the sessile bacterial lifestyle biofilms has been seen since it was realized that that less than 0.1% of the total microbial biomass lives in the planktonic mode of growth. The term was coined in 1978 by Costerton et al. who defined the term biofilm for the first time.In 1993 the American Society for Microbiology (ASM) recognised that the biofilmmode of growth was relevant to microbiology. Lately many articles have been published on the clinical implications of bacterial biofilms. Both original articles and reviews concerning the biofilm problem are available.

Author Biography

Thomas Bjarnsholt, Ph.D., Falculty of Health Sciences, University of Copenhagen and Dept. of Clinical Microbiology, Rigshospitalet, Denmark Peter strup Jensen, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Claus Moser, MD, Ph.D., Dept. of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark Niels Hiby, Dr. Med. Scient., Falculty of Health Sciences, University of Copenhagen and Dept. of Clinical Microbiology, Rigshospitalet, Denmark

Table of Contents

Introduction to Biofilms	p. 1
Chronic Wound Colonization, Infection, and Biofilms	p. 11
The Relation of Biofilms to Chronic Otitis Media and Other Ear-Related Chronic Infections	p. 25
Human Oral Bacterial Biofilms: Composition, Dynamics, and Pathogenesis	p. 35
Implant-Associated Infection	p. 69
The Role of Bacterial Biofilms in Infections of Catheters and Shunts	p. 91
Osteomyelitis	p. 111
The Importance of Biofilms in Chronic Rhinosinusitis	p. 139
Helicobacter pylori and Biofilm Formation	p. 161
Pseudomonas aeruginosa Biofilms in the Lungs of Cystic Fibrosis Patients	p. 167
Innate Immune Response to Infectious Biofilms	p. 185
Adaptive Immune Responses and Biofilm Infections	p. 201
Antibiotic Tolerance and Resistance in Biofilms	p. 215
Novel and Future Treatment Strategies	p. 231
Different Methods for Culturing Biofilms in Vitro	p. 251
In Vivo Models of Biofilm Infection	p. 267
Summary and Perspectives	p. 291
Index	p. 295
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