Bioinformatics and Biomarker Discovery : Omic Data Analysis for Personalized Medicine

by Editor: William Herman (University of Michigan Medical Center); Co-Editor: Ann Louise Kinmonth (Institute for Public Health ); Co-Editor: Nick Wareham (Institute of Public Health ); Co-Editor: Rhys Williams (Diabetes )

• ISBN13: 9780470682814
• ISBN10: 0470682817
• Format: eBook
• Copyright: 2009-12-01
• Publisher: Wiley

Summary

This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems.The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications.Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarise biological/clinical implications and provide alternative interpretations

Table of Contents

Review Contributors

Foreword

Preface to Third Edition

Preface to First Edition

Diagnosis of Depressive Disorders

Commentaries

Four Questions and an Alternative

The Blurring of Caseness in Depressive Disorders

Fresh Look at Alternatives for Diagnosing Depression

Severity and Subtypes of Depression

Severe Depression and Melancholia

The Need to Functionalise Psychiatric Diagnosis

Pharmacological Treatment of Major Depressive Disorder: A Review

Commentaries

Antidepressants: A Well-Evaluated Class of Medications

Many Variables Affect Clinical Response

Challenges in Concept and Practice

The Relevance to Psychiatry in Developing Countries

New Evidence and Caution

Specific Actions, Patient Subgroups and Stages of Illness

The French Experience

Psychotherapies for Depression in Adults: A Review of Recent Developments

Commentaries

The Paradox of Evidence-Based Psychotherapy

Incorporating the Insights of Psychotherapy Research in Everyday Practice

Psychotherapy for Depressed Patients in Low- and Middle-Income Countries, Particularly in Asia

Research and Synergies across Countries and Cultures

A Wider Cultural Perspective

Depression in Children and Adolescents: A Review

Commentaries

Advances in Understanding Prevention and Treatment and the Needs in Developing Countries

The Risks of Bipolar Disorder

The Need for Specifically Targeted and Precise Treatments Aiming for Remission

Childhood Depression is Distinct from Depression in Adolescents and Adults

Depression in Infants, Children and Adolescents

Depressive Disorders in the Elderly: A Review

Commentaries

Focusing on Asia

Effective Treatments Despite Diagnostic Complexity and Diverse Populations

Depression and Anxiety in Dementia Caregivers

Recognition of Old Age Depression in Chinese

Treatment of Depressive Disorders in Elderly Complicated with Medical Co-morbidities and Multiple Medication Use

Depressive Disorders in Primary Care: A Review

Commentaries

A Paradox of Screening for Mental Disorders in Primary Care and the Importance of Severe Disorders in Developing Countries

Diagnosis, Intervention and the Emergence of the Patient's Voice

Untreated Depression in Mexico - Can Primary Care Make a Difference?

Understanding the Practice of Primary Health Care

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