Bioinformatics - From Genomes to Drugs, 2 Volume Set,

by Editor: Thomas Lengauer (Max-Planck-Institute for Informatics, Saarbruecken, Germany); Series Editor: Raimund Mannhold (Inst. f. Lasermedizin, Dü; sseldorf, Germany); Series Editor: Hugo Kubinyi (BASF AG, Ludwigshafen, Germany); Series Editor:

• ISBN13: 9783527299881
• ISBN10: 3527299882
• Format: Hardcover
• Copyright: 2002-03-01
• Publisher: Wiley-VCH

Summary

Bioinformatics - the use of computers to retrieve, process, analyze and simulate biological information - promises to revolutionize the process of drug discovery and development. This book provides a broad, application-oriented overview of this technology. Contributions by internationally renowned specialists in the field afford a detailed insight into single bioinformatics components and algorithmic methods. In addition, the state-of-the-art in bioinformatics is evaluated equally from a global view by introducing real application scenarios such as genome projects that require the use of a whole set of bioinformatics tools. The profound knowledge on bioinformatics presented here not only enables readers to go beyond a mere push-button approach to using bioinformatics software and interpreting the data generated appropriately. It is also essential to assess the potential and limitations of today's bioinformatics software and future challenges. Directed to all those involved in the use or development of new bioinformatics tools - scientists and managers from the fields of molecular biotechnology, pharmaceutics, and medicinal chemistry - this book will lead one step further on the way to rational drug design

Author Biography

Thomas Lengauer (born 1952) studied Mathematics and Informatics at Berlin and Stanford. After a brief stay at the Bell Laboratories, he held various academic positions at the universities of Saarbruecken, Paderborn, and Bonn. From 1992 to 2001, he headed the Institute for Algorithms and Scientific Computing at the GBM in Sankt Augustin (Germany). Since 2001, he is director at the Max-Planck-Institute for Informatics in Saarbruecken (Germany).<br> Professor Lengauer has recently been awarded the Konrad-Zuse-Medal, the highest honor of the German Informatics Society.<br>

Table of Contents

VOLUME I: BASIC TECHNOLOGIES

List of Contributors.

Foreword.

From Genomes to Drugs with Bioinformatics.

Sequence Analysis.

Structure, Properties and Computer Identification of Eukaryotic Genes.

Analyzing Regulatory Regions in Genomes.

Homology Modeling in Biology and Medicine.

Protein Structure Prediction.

Protein-Ligand Docking in Drug Design.

Modelling Protein-Protein and Protein-DNA Docking.

Appendix: Glossary of Algorithmic Terms in Bioinformatics.

Subject Index.

Name Index

VOLUME II: APPLICATIONS.

List of Contributors.

Foreword.

Integrating and Accessing Molecular Biology Resources.

Bioinformatics Support of Genome Sequencing Projects.

Analysis of Sequence Variations.

Proteome Analysis.

Target Finding in Genomes and Proteomes.

Screening of Drug Databases.

Future Trends.

Subject Index.

Name Index