Bioinformatics and Functional Genomics, 2nd Edition

by Jonathan Pevsner (Department of Neurology, Kennedy Krieger Institute and Department of Neuroscience and Division of Health Sciences Informatics, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA)

• ISBN13: 9780470451489
• ISBN10: 0470451483
• Format: eBook
• Copyright: 2009-04-01
• Publisher: Wiley-Blackwell
• More Book Details
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Summary

Eagerly awaited, the second edition of the best-selling Bioinformatics and Functional Genomics has been thoroughly updated and enhanced. The text continues to offer the most broad-based introduction to this explosive new discipline, combining theoretical context with practical applications.Bioinformatics and Functional Genomics is a textbook for undergraduate students, graduate students, and anyone involved in biomedical research. The first third of this book covers bioinformatics, a new field at the interface of the ongoing revolutions in molecular biology and computers. A focus of this new discipline is the use of computer databases and computer algorithms to study proteins and genes, including sequence alignment, database searches, and phylogeny. The middle third of this book focuses on functional genomics including approaches such as gene expression profiling and proteomics that are used to study cellular function. The last third of the book is on genomics which is the study of the collection of DNA that comprises an organism, using the tools of bioinformatics. This portion of the book spans the tree of life from viruses to prokaryotes and eukaryotes, including a description of the human genome in health and disease.Highlight features: Attractive two-color design throughout, with a section of full-color figures Lavishly illustrated, featuring over 500 figures and tables with 50 NEW figures and tables in this edition Highlights how the tools of bioinformatics can be used to further our understanding of basic processes in cell and molecular biology and genomics NEW to the second edition: Several fundamentally important proteins (such as histones, insulin, globins, and albumins) are included to better show how to apply bioinformatics tools to basic biological questions Strong focus on the relevance of bioinformatics tools to the understanding of human disease Each chapter includes a Problem Set, Pitfalls section, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading, and a list of freely available SoftwarePraise for the first edition:"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology"... an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering"...highly recommended for academic and medical libraries, and for researchers as an introduction and reference..." E-Streams

Table of Contents

Preface to the Second Edition

Preface to the First Edition

Foreword

Analyzing Dna, Rna, And Protein Sequences In Databases

Introduction

Access to Sequence Data and Literature Information

Pairwise Sequence Alignment

Basic Local Alignment Search Tool (BLAST)

Advanced Database Searching

Multiple Sequence Alignment

Molecular Phylogeny and Evolution

Genomewide Analysis Of Rna And Protein

Bioinformatic Approaches to Ribonucleic Acid (RNA)

Gene Expression: Microarray Data Analysis

Protein Analysis and Proteomics

Protein Structure

Functional Genomics

Genome Analysis

Completed Genomes

Completed Genomes: Viruses

Completed Genomes: Bacteria and Archaea

The Eukaryotic Chromosome

Eukaryotic Genomes: Fungi

Eukaryotic Genomes: From Parasites to Primates

Human Genome

Human Disease

Glossary

Answers to Self-Test Quizzes

Author Index

Subject Index

Table of Contents provided by Publisher. All Rights Reserved.