Bioinformatics: A Practical Approach

by Ye; Shui Qing

• ISBN13: 9781584888109
• ISBN10: 1584888105
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-08-20
• Publisher: Chapman & Hall/

Summary

An emerging, ever-evolving branch of science, bioinformatics has paved the way for the explosive growth in the distribution of biological information to a variety of biological databases, including the National Center for Biotechnology Information. For growth to continue in this field, biologists must obtain basic computer skills while computer specialists must possess a fundamental understanding of biological problems. Bridging the gap between biology and computer science, Bioinformatics: A Practical Approach assimilates current bioinformatics knowledge and tools relevant to the omics age into one cohesive, concise, and self-contained volume.Written by expert contributors from around the world, this practical book presents the most state-of-the-art bioinformatics applications. The first part focuses on genome analysis, common DNA analysis tools, phylogenetics analysis, and SNP and haplotype analysis. After chapters on microarray, SAGE, regulation of gene expression, miRNA, and siRNA, the book presents widely applied programs and tools in proteome analysis, protein sequences, protein functions, and functional annotation of proteins in murine models. The last part introduces the programming languages used in biology, website and database design, and the interchange of data between Microsoft Excel and Access.Keeping complex mathematical deductions and jargon to a minimum, this accessible book offers both the theoretical underpinnings and practical applications of bioinformatics.

Table of Contents

Preface	p. ix
Editor	p. xiii
Contributors	p. xv
Abbreviations	p. xix
Genome Analysis	p. 1
Two Common DNA Analysis Tools	p. 55
Phylogenetic Analysis	p. 81
SNP and Haplotype Analyses	p. 107
Gene Expression Profiling by Microarray	p. 131
Gene Expression Profiling by SAGE	p. 189
Regulation of Gene Expression	p. 219
MicroRNoma Genomewide Profiling by Microarray	p. 251
RNAi	p. 271
Proteomic Data Analysis	p. 285
Protein Sequence Analysis	p. 333
Protein Function Analysis	p. 379
Functional Annotation of Proteins in Murine Models	p. 425
Application of Programming Languages in Biology	p. 449
Web Site and Database Design	p. 505
Microsoft Excel and Access	p. 545
Selected Web sites	p. 583
Glossary	p. 587
Index	p. 599
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