A Biologic Approach to Environmental Assessment and Epidemiology

by Smith, Thomas J.; Kriebel, David

• ISBN13: 9780195141566
• ISBN10: 0195141563
• Format: Hardcover
• Copyright: 2010-07-02
• Publisher: Oxford University Press

Summary

Environmental chemical hazards are a highly contentious topic in modern life. Nearly every nation on earth has faced its own environmental crises, and also shares perspectives on the possibility of global catastrophes. Of the many global concerns we face, the environmental issue is unique in many ways. The greatest of these is the fundamental scientific nature of the issue, and the extent to which our opinions are formed based on high-level scientific inquiry and assessment. The two key fields of study on this issue, environmental epidemiology and exposure assessment, are still given separate names because of their separate historical roots and scientific traditions, but are seen increasingly as inseparable aspects of the same basic investigation. In this book, Thomas J. Smith and David Kriebel assert that important advances in the quantification of environmental risks can only come through a true synthesis of the two fields. They have built a common biologic model of exposure, physiologic response, and disease, a synthesis of the various existing models which serves to both simplify and improve the application of environmental epidemiology and exposure assessment to current and future environmental chemical risks. When exposure assessor and epidemiologist agree from the start on the model for their study, the conceptual framework for the study they design and the analyses they carry out are much more likely to yield useful exposure-risk information. An explicit biologic model of the apparent processes linking exposure to disease should form the basis for any study seeking to quantify risk from environmental chemicals.

Author Biography

Thomas J. Smith, Ph.D., is Professor of Industrial Hygiene in the Department of Environmental Health, Harvard School of Public Health. He has more than 30 years of experience developing exposure assessments for health studies in a wide variety of occupational and environmental settings, including development of methods to estimate long-term past exposures for studies of cancer and chronic diseases, and exposure-based models of tissue dose and responses.
David Kriebel, SC. D., is Professor and Chair in the Department of Work Environment, University of Massachusetts Lowell. Dr. Kriebel is also Co-Director of the Lowell Center for Sustainable Production and is an environmental and occupational epidemiologist with 25 years of experience in the design and analysis of epidemiologic studies. He is a co-author, with Harvey Checkoway and Neil Pearce, of Research Methods in Occupational Epidemiology, 2nd edition (Oxford University Press, 2004).

Table of Contents

Introduction - Relating Disease to Exposure

Exposure and Disease in Individuals

Characteristics of Exposure

Exposure Characterization for Epidemiology

Personal Exposure-Tissue Concentration Relationships

Biomarkers as Indicators of Exposure

Disease Process Models

Exposure and Disease in Populations

Epidemiologic Evaluation of Environmental Hazards

Uncertainty in Measuring Risk

Dosimetry in Epidemiology

Practical Applications of Disease Process Models

Modeling Proportional Disease Processes

Effects of Ammonia and Ozone on Respiratory Symptoms: Examples of Reversible Proportional Disease Processes

Neurobehavioral Effects of Mercury and Popcorn Workers' Lung: Examples of Irreversible Proportional Diseases Processes

Modeling Discrete Disease Processes

Asthma & Indoor Air, Dermatitis & Metalworking Fluids: Examples of Discrete Reversible Disease Processes

Irreversible Discrete Processes

Where Do We Go From Here?

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