Biologic Therapy of Cancer

by Devita, Vincent T.; Hellman, Samuel; Rosenberg, Steven A.

• ISBN13: 9780397514168
• ISBN10: 0397514166
• Edition: 2nd
• Format: Hardcover
• Copyright: 1995-03-01
• Publisher: Lippincott Williams & Wilkins

Table of Contents

Principles of Biologic Therapy of Cancer	p. 1
Biology of Cellular Immune Responses	p. 3
Biology of Antibody-Mediated Responses	p. 39
Biology of Tumor Antigens	p. 53
Genes Coding for Tumor Antigens Recognized by T Lymphocytes
Tumor Antigens Recognized by Immune Cells	p. 64
Tumor Antigens Recognized by Monoclonal Antibodies	p. 77
Biology of Cytokines: The Interleukins	p. 87
Principles of Cell Killing by Biologic Agents	p. 95
Immunocompetence and Cancer	p. 103
Biologic Therapy of Cancer	p. 119
Colony-Stimulating Factors: Basic Principles and Preclinical Studies	p. 121
Colony-Stimulating Factors: Clinical Applications	p. 141
Granulocyte-Stimulating Factors	p. 141
Platelet-Stimulating Factors	p. 183
Erythrocyte-Stimulating Factors	p. 190
Macrophage-Colony Stimulating Factor	p. 201
Biologic Therapy with Interleukin-2: Preclinical Studies	p. 207
Biologic Therapy with Interleukin-2: Clinical Applications	p. 235
Principles of Administration and Management of Side Effects	p. 235
Melanoma	p. 250
Renal Cell Cancer	p. 262
Other Cancers	p. 269
Role of IL-4, IL-6, and IL-12 in Cancer Therapy	p. 279
Biologic Therapy with TNF: Preclinical Studies	p. 295
Biologic Therapy with TNF: Systemic Administration and Isolation-Perfusion	p. 329
Biologic Therapy with Interferon-[alpha] and [beta]: Preclinical Studies	p. 347
Biologic Therapy with Interferon-[alpha] and [beta]: Clinical Applications	p. 365
Hairy Cell Leukemia, Chronic Myelogenous Leukemia, and Myeloproliferative Disorders	p. 365
Renal Cell Cancer	p. 373
Melanoma	p. 388
Kaposi's Sarcoma	p. 411
Multiple Myeloma	p. 420
Clinical Applications of Interferon in Other Tumors	p. 427
Biologic Therapy with Interferon-[gamma]	p. 435
Combination Cytokine Therapy	p. 443
Cell Transfer Therapy: Preclinical Studies	p. 467
Cell Transfer Therapy: Clinical Applications	p. 487
Monoclonal Antibodies in Cancer Therapy	p. 507
Basic Principles	p. 507
Immunotoxins and Recombinant Toxins	p. 521
Radioisotope Conjugates	p. 534
Clinical Applications of Monoclonal Antibodies in Cancer	p. 553
B-Cell Lymphomas	p. 553
T-Cell Leukemia/Lymphoma	p. 566
Melanoma	p. 576
Adenocarcinomas	p. 590
Purging of Bone Marrow	p. 596
Antibodies to Growth Factors and Receptors	p. 607
Cancer Vaccines: Preclinical Studies	p. 625
Cancer Vaccines: Clinical Applications	p. 635
Immune Adjuvants	p. 635
Whole Cell Vaccines	p. 648
Viral Oncolysates	p. 659
Partially Purified Tumor Antigen Vaccines	p. 668
Immunization with Synthetic or Highly Purified Tumor Antigens	p. 680
Local Therapy with Biologic Agents	p. 691
Intralesional Therapy	p. 691
Instillation Therapy for Bladder Cancer	p. 705
Gene Therapy of Cancer	p. 713
Basic Principles and Safety Considerations	p. 713
Gene Therapy Using Lymphocyte Modification	p. 727
Gene Therapy Using Stem Cell Modification	p. 738
Gene Therapy Using "Suicide" Genes	p. 746
Gene Therapy by Direct Gene Transfer	p. 750
Antisense Oligodeoxynucleotides	p. 759
Gene Modification of Tumors	p. 774
Other Approaches to Biologic Therapy	p. 785
Chemically Defined Immunomodulators and Interferon Inducers	p. 787
Levamisole	p. 795
Differentiation Agents	p. 803
Tamoxifen	p. 817
Systemic Activation of Macrophages by Liposomes Containing Immunomodulators	p. 829
Thymosin	p. 841
Antimetastatic Therapy	p. 853
Interaction of Biologic Agents with Chemotherapy	p. 863
Regulatory Issues Related to Biologic Agents	p. 877
Development of Biological Therapeutics for Oncologic Use	p. 879
Index	p. 891
Table of Contents provided by Blackwell. All Rights Reserved.