Biological Regulation of the Chondrocytes

by Adolphe; Monique

• ISBN13: 9780849367335
• ISBN10: 0849367336
• eBook ISBN(s): 9781351463935
• Format: Hardcover
• Copyright: 1992-06-16
• Publisher: CRC Press
• More Book Details

Summary

Biological Regulation of the Chondrocytes provides a comprehensive examination of the various regulations in which cartilaginous cells are involved. The book's introductory chapter provides an overview of the different types of chondrocyte, while following chapters discuss the various biological regulations implicated in chondrocyte functions, especially the modulation of differentiative properties. Chapters 2 and 3 examine the extracellular matrix components, and Chapter 4 discusses the special case of cultured chondrocytes and the usefulness of in vitro approaches. The following three chapters focus on the complex role of cartilaginous growth factors and cytokines (FGF, TGFB, IGF, and IL1) on the modulation of the chondrocyte properties. Chapter 9 discusses the synoviocyte, and the last four chapters examine the biochemical and molecular perturbations that appear during repair, aging, rheumatic disease, and cancer.Biological Regulation of the Chondrocytes will benefit rheumatologists, pharmaceutical researchers, physiologists, connective tissue specialists, and students and other researchers in the osteoarticular field.

Table of Contents

The Different Types of Chondrocytes and Their Function In Vivo	p. 1
Cartilage Collagens	p. 33
Proteoglycan, Hyaluronan, and Noncollagenous Matrix Protein Metabolism by Chondrocytes	p. 85
Different Types of Cultured Chondrocytes--The In Vitro Approach to the Study of Biological Regulation	p. 105
Roles of Fibroblast Growth Factor and Transforming Factor-[Beta] Families in Cartilage Formation	p. 141
Role of IGF in the Regulation of Chondrocytes	p. 161
Regulation of Chondrocytes by Cytokines	p. 191
Intercellular Regulation by Synoviocytes	p. 205
Articular Cartilage Repair: Potential Role of Growth and Differentiation Factors	p. 227
Regulation of Chondrocytes in Aging	p. 237
Regulation of Chondrocytes in Rheumatoid Arthritis	p. 275
Regulation of Chondrocytes in Osteoarthrosis	p. 295
Regulation of Tumor Derived and Immortalized Chondrocytes	p. 321
Index	p. 339
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