The Biology of Disease

by Phillips, Jonathan; Murray, Paul G.; Kirk, Paul

• ISBN13: 9780632054046
• ISBN10: 0632054042
• Edition: 2nd
• Format: Paperback
• Copyright: 2001-05-08
• Publisher: Wiley-Blackwell

Summary

The second edition of The Biology of Disease is an introductory level text on the biological principles of human disease. The book is aimed at medical students in degree courses in biomedical science.The book fuses the biological (physiological and biochemical) processes which underlie the clinical manifestations of disease. As such, it brings together material which is conventionally dealt with by several books. The authors have covered the fundamentals of each topic in a readable manner, which should encourage students to develop a fuller understanding, where necessary, by reference to more comprehensive texts. Integrates basic science and clinical medicine. Detailed case studies at the end of each chapter which emphasise the clinical setting. New chapters on transplantation immunology, anaemia, toxicology & poisoning. The use of non-technical language for the descriptions in the case studies to ensure that all students will comprehend the underlying principles.

Author Biography

Jonathan Phillips is Professor of Crusading History at Royal Holloway, University of London. Paul G. Murray is the editor of The Biology of Disease, 2nd Edition, published by Wiley.

Table of Contents

List of Contributors	vii
Preface to the Second Edition	xi
Preface to the First Edition	xii
The Nature of Disease	1	(4)
Psychological and Social Aspects of Disease	5	(5)
Principles of Epidemiology	10	(18)
The epidemiology of colorectal cancer	22	(4)
Epidemic asthma days in Barcelona	26	(2)
The Molecular Basis of Cell Reproduction, Senescence and Death	28	(11)
The Inflammatory Response	39	(10)
The Immune System	49	(11)
Principles of Infectious Disease	60	(9)
Bacterial Infection	69	(8)
Virus Infections	77	(12)
Hypersensitivity	89	(9)
Autoimmunity	98	(9)
Immunodeficiency	107	(8)
Transplantation Immunology	115	(9)
Anaemia	124	(9)
Nutritional Disorders	133	(9)
Disorders of Haemostasis	142	(9)
Atherosclerosis	151	(5)
Toxicology and Poisoning	156	(9)
Inherited Single Gene Disorders	165	(10)
Chromosome Abnormalities	175	(8)
Principles of Neoplasia	183	(10)
The Molecular Basis of Cancer	193	(11)
Tumour Viruses and Human Cancer	204	(10)
Cancer: Invasion and Metastasis	214	(88)
Case Studies
Neurotic symptoms following a road traffic accident	222	(2)
Depressive illness in pregnancy	224	(1)
Fever, vomiting and neck stiffness in a child	225	(2)
Shortness of breath and vaginal discharge	227	(4)
Fever with chills and rigors	231	(3)
Fever, confusion and breathlessness	234	(3)
Coughing up of blood by a retired coal miner	237	(2)
Persistent coughing up of blood and ankle swelling	239	(2)
Breathlessness in a young man	241	(1)
Diarrhoea, jaundice and rash	242	(2)
Protein in the urine and high blood pressure	244	(2)
Fever and cervical lymph node enlargement	246	(2)
Neutropenia and recurrent infection in a patient with rheumatoid arthritis	248	(2)
Fever and leg ulcer	250	(3)
Chest pain radiating to the left arm	253	(2)
Unexpected death in a young man	255	(2)
Easy bruising and recurrent nose bleeds	257	(4)
Diarrhoea and abdominal distension	261	(2)
Abdominal pain and diarrhoea	263	(1)
Recurrent epigastric pain with abnormal liver function tests	264	(3)
Sudden onset of severe pain in the leg	267	(2)
Rectal bleeding with diarrhoea	269	(2)
Heart murmur and cleft plate	271	(3)
Seizures, aggressive behaviour,; Rett syndrome---affected sister	274	(1)
Recurrent miscarriage	275	(3)
Neonate with dysmorphic features and high-pitched cry	278	(2)
Meconium ileus in a newborn	280	(2)
Back pain, lethargy and weight loss	282	(2)
Addendum: Approaches to cancer therapy	284	(2)
Essay bruising, weight loss and abdominal discomfort	286	(2)
Bledding from the nose and gums with fever	288	(2)
Nights sweats and cervical lymph node enlargement	290	(3)
Hoarseness and weight loss	293	(3)
Burning sensation during urination, weight loss and skeletal pain	296	(3)
Change of bowel habit and bleeding from the rectum	299	(3)
Case Study Answers	302	(10)
Appendix	312	(3)
Index	315