Biomaterials For Delivery And Targeting of Proteins And Nucleic Acids

by Mahato; Ram I.

• ISBN13: 9780849323348
• ISBN10: 0849323347
• Format: Hardcover
• Copyright: 2004-12-28
• Publisher: CRC Press

Summary

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

Table of Contents

Structure, properties, and characterization of polymeric biomaterials

Step-growth and ring-opening polymerization

Copolymers, block copolymers, and stimuli-sensitive polymers

Polymer solution properties, micelles, dendrimers, and hydrogels

Protein conjugation, cross-linking, and PEGylation

Complement activation by injectable colloidal drug carriers

Biological membranes and barriers

Pharmacokinetics of protein- and nucleotide-based drugs

In vivo fate of polymeric gene carriers

Subcellular fate of proteins and nucleic acids

Stability of proteins and nucleic acids

Formulation, stability, and characterization of protein and peptide drugs

Micro- and nanoparticulate polymeric delivery systems for nucleic acid-based medicine

Liposomal delivery of protein and peptide drugs

Mechanisms of cellular drug resistance and strategies to overcome it

Transporters as molecular targets for drug delivery and disposition

Protein transduction domain as a novel tool for delivery of proteins, peptides and nucleic acids

Introduction to therapeutic nucleic acids

Antisense and antigene oligonucleotides : structure, stability and delivery

Artificial nucleic acid chaperones

Basic components of plasmid-based gene expression systems

Design elements of polymeric gene carriers

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