Biomaterials Engineering and Devices: Human Applications

by Wise, Donald L.; Trantolo, Debra J.; Lewandrowski, Kai-Uwe; Gresser, Joseph D.; Cattaneo, Maurizio V.

• ISBN13: 9780896038585
• ISBN10: 0896038580
• Format: Hardcover
• Copyright: 2000-08-01
• Publisher: Humana Pr Inc

Summary

Authoritative international experts comprehensively review many current state-of-the-art uses of polymers, metals, and ceramics in the human body. A veritable encyclopedia of valuable data and experience, this volume not only fully addresses the major issues of compatibility and functionality, but also provides a technical treatise on the design and evaluation of biomaterials for vascular application and on biomaterials as carriers for bioactive agents. A second volume, Biomaterials Engineering and Devices: Human Applications, Volume 2 is devoted to biomaterials for dental applications, bony biomaterials for grafting applications, and orthopedic fixtures and cements. Extensively illustrated and referenced, Biomaterials Engineering and Devices: Human Applications, Volume 1: Fundamentals and Vascular and Carrier Applications integrates for today's bioengineering professionals the basic science, engineering, and practical medical experience needed to meet the ever-growing demand for new and better biomaterials.

Table of Contents

Preface	p. v
Contributors	p. ix
About the Editors	p. xiii
Contents of Volume 2	p. xv
Compatibility and Functionality Issues in Applied Biomaterials
Molecular Mechanism of Biomaterial-Mediated Phagocyte Responses	p. 3
Hypersensitivity Associated with Metallic Biomaterials	p. 15
Blood-Compatible Bioactive Polymers	p. 25
Novel Modification Method of Bioprosthetic Tissue for Improved Calcification Resistance	p. 49
Biocompatibility of Silicone Gel Breast Implants	p. 57
Endothelialization of Vascular Prostheses	p. 85
Design and Evaluation of Materials for Vascular Applications
Collagen-Based Vascular Prostheses	p. 121
Surface Modifications of Mechanical Heart Vales: Effects on Thrombogenicity	p. 137
The Importance of Radial Forces in Vascular Stent Design	p. 145
Blood Leak-Proof Porous Vascular Grafts	p. 161
Formation of Neointima in Vascular Prosthesis Sealed with Autologous Adipose Tissue Fragments for Femoropopliteal Bypass	p. 181
Clinical Improvement in Patients with Coronary and Peripheral Vascular Diseases Treated by LDL-Adsorption Using the Liposorber LA-15 System	p. 189
Development of a New Hybrid Coronary Stent Design with Optimized Biocompatible Properties	p. 201
Biomaterials as Carriers for Bioactive Agents
Incorporation of Active Agent into Biodegradable Cement: Encapsulation of Agent as Protection from Chemical Degradation During Cure and Effect on Release Profile	p. 225
New Synthetic Degradable Polymers as Carrier Materials for BMP	p. 239
Use of Carrier Materials in Delivery of Bone Inductor Substances	p. 251
Preclinical and Clinical Evaluation of Osteogenic Protein-1 (BMP-7) in Bony Sites	p. 267
Enzyme-Based Artificial Liver Support: A Computerized Expert System for Design, Optimization, and Operation Control	p. 279
Bupivacaine Release from Biopolymeric Depots for the Alleviation of Postoperative Pain	p. 295
Biomaterial Implants for Treatment of Central Nervous System Diseases	p. 307
Index	p. 335
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