Biomaterials Science

This second edition of Biomaterials Science leads the field by providing a balanced, insightful view of biomaterials. Contributions from pre-eminent researchers and practitioners from diverse academic and professional backgrounds have been integrated into a cohesive curriculum which includes pertinent principles of cell biology, immunology and pathology focusing on the clinical uses of biomaterials as components of implants, devices, and artificial organs, and their uses in biotechnology. The materials science and engineering of synthetic and natural biomaterials and the characterization of their physical, chemical, biochemical and surface properties, and mechanisms and evaluation of interactions with tissue, are also addressed in detail. Book jacket.

Editors and Lead Contributors	p. ix
Preface	p. xi
Biomaterials Science: A Multidisciplinary Endeavor	p. 1
A History of Biomaterials	p. 10
Materials Science and Engineering
Properties of Materials
Introduction	p. 23
Bulk Properties of Materials	p. 23
Finite Element Analysis	p. 32
Surface Properties and Surface Characterization of Materials	p. 40
Role of Water in Biomaterials	p. 59
Classes of Materials Used in Medicine
Introduction	p. 67
Polymers	p. 67
Silicone Biomaterials: History and Chemistry	p. 80
Medical Fibers and Biotextiles	p. 86
Hydrogels	p. 100
Applications of "Smart Polymers" as Biomaterials	p. 107
Bioresorbable and Bioerodible Materials	p. 115
Natural Materials	p. 127
Metals	p. 137
Ceramics, Glasses, and Glass-Ceramics	p. 153
Pyrolytic Carbon for Long-Term Medical Implants	p. 170
Composites	p. 181
Nonfouling Surfaces	p. 197
Physicochemical Surface Modification of Materials Used in Medicine	p. 201
Textured and Porous Materials	p. 218
Surface-Immobilized Biomolecules	p. 225
Biology, Biochemistry, and Medicine
Some Background Concepts
Background Concepts	p. 237
The Role of Adsorbed Proteins in Tissue Response to Biomaterials	p. 237
Cells and Cell Injury	p. 246
Tissues, the Extracellular Matrix, and Cell-Biomaterial Interactions	p. 260
Mechanical Forces on Cells	p. 282
Host Reactions to Biomaterials and Their Evaluation
Introduction	p. 293
Inflammation, Wound Healing, and the Foreign-Body Response	p. 296
Innate and Adaptive Immunity: The Immune Response to Foreign Materials	p. 304
The Complement System	p. 318
Systemic Toxicity and Hypersensitivity	p. 328
Blood Coagulation and Blood-Materials Interactions	p. 332
Tumorigenesis and Biomaterials	p. 338
Biofilms, Biomaterials, and Device-Related Infections	p. 345
Biological Testing of Biomaterials
Introduction to Testing Biomaterials	p. 355
In Vitro Assessment of Tissue Compatibility	p. 356
In Vivo Assessment of Tissue Compatibility	p. 360
Evaluation of Blood-Materials Interactions	p. 367
Large Animal Models in Cardiac and Vascular Biomaterials Research and Testing	p. 379
Microscopy for Biomaterials Science	p. 396
Degradation of Materials in the Biological Environment
Introduction: Degradation of Materials in the Biological Environment	p. 411
Chemical and Biochemical Degradation of Polymers	p. 411
Degradative Effects of the Biological Environment on Metals and Ceramics	p. 430
Pathological Calcification of Biomaterials	p. 439
Application of Materials in Medicine, Biology, and Artificial Organs
Introduction	p. 455
Nonthrombogenic Treatments and Strategies	p. 456
Cardiovascular Medical Devices	p. 470
Implantable Cardiac Assist Devices	p. 494
Artificial Red Blood Cell Substitutes	p. 507
Extracorporeal Artificial Organs	p. 514
Orthopedic Applications	p. 527
Dental Implantation	p. 556
Adhesives and Sealants	p. 573
Ophthalmological Applications	p. 584
Intraocular Lens Implants: A Scientific Perspective	p. 592
Burn Dressings and Skin Substitutes	p. 603
Sutures	p. 615
Drug Delivery Systems	p. 629
Bioelectrodes	p. 649
Cochlear Prostheses	p. 658
Biomedical Sensors and Biosensors	p. 670
Diagnostics and Biomaterials	p. 685
Medical Applications of Silicones	p. 698
Tissue Engineering
Introduction	p. 709
Overview of Tissue Engineering	p. 712
Immunoisolation	p. 728
Synthetic Bioresorbable Polymer Scaffolds	p. 735
Practical Aspects of Biomaterials
Implants, Devices, and Biomaterials: Issues Unique to this Field
Introduction	p. 753
Sterilization of Implants and Devices	p. 754
Implant and Device Failure	p. 760
Correlation, Surfaces and Biomaterials Science	p. 765
Implant Retrieval and Evaluation	p. 771
New Products and Standards
Introduction	p. 783
Voluntary Consensus Standards	p. 783
Development and Regulation of Medical Products Using Biomaterials	p. 788
Ethical Issues in the Development of New Biomaterials	p. 793
Legal Aspects of Biomaterials	p. 797
Perspectives and Possibilities in Biomaterials Science	p. 805
Properties of Biological Fluids	p. 813
Properties of Soft Materials	p. 819
Chemical Compositions of Metals Used for Implants	p. 823
The Biomaterials Literature	p. 825
Index	p. 831
Table of Contents provided by Rittenhouse. All Rights Reserved.

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