Biomedical Aspects of Histamine

by Khardori, Nancy; Shahid, Mohammed; Khan, Rahat Ali; Tripathi, Trivendra

• ISBN13: 9789048193486
• ISBN10: 9048193486
• Edition: 1st
• Format: Hardcover
• Copyright: 2010-10-29
• Publisher: Springer Verlag

Summary

Since its identification by Sir Henry H. Dale a century ago, histamine has become one of the most important multifunctional biogenic amines in the field of biomedicine. The pharmacological effects of histamine are mediated through four types of membrane histamine receptors; H1R, H2R, H3R and H4R, which are all heptahelical G-protein-coupled receptors. It has been known to play the broadest spectrum of activities in various physiological and pathological conditions including cell proliferation, differentiation, hematopoiesis, embryonic development, regeneration, wound healing, aminergic neurotransmission and numerous brain functions, secretion of pituitary hormones, regulation of gastrointestinal and circulatory functions, cardiovascular system, as well as inflammatory reactions, modulation of the immune response, endocrine function and homeostasis, and other important areas. This book is a compendium of the current state of established and investigational literature on Histamine, its receptors and their Agonists and antagonists. It provides a comprehensive overview of histamine biology in the field of biochemistry, cell biology, molecular biology, immunology, allergy, neurobiology, pharmacology, microbiology and reproductive biology. The first section on Histamine biology and physiology leads into subsequent sections on enzymology, pharmacology, regulation of the immune system and cell proliferation and role in allergic and other diseases including acid peptic diseases, inflammatory diseases, autoimmune and cancer diseases, nervous system, reproductive functions and hematopoiesis. The compilation of chapters in the book presents the most recent advances in histamine research and bridges the basic and clinical aspects of histamine biology.

Table of Contents

Histamine Biology and Physiology
An Overview of Histamine Synthesis, Regulation and Metabolism, and its Clinical Aspects in Biological System	p. 3
Regulation of Mammalian Histamine Synthesis: Histidine Decarboxylase	p. 15
Enzymology in Histamine Biology
Enzymology in Histamine Biogenesis	p. 33
Pharmacology of Histamine Noble Receptors and Their Ligands in Drug Development
Biological and Pharmacological Aspects of Histamine Receptors and Their Ligands	p. 61
Histamine Role in Immune Modulation and Regulation
The Role of Histamine in Immunoregulation in Context of T-Regulatory and Invariant NKT Cells	p. 103
Immune Regulation by Various Facets of Histamine in Immunomodulation and Allergic Disorders	p. 133
Histamine in Regulation of Cell Proliferation and Differentiation
Effects of Histamine on Lymphocytes	p. 151
Histamine Aspects in Acid Peptic Diseases and Cell Proliferation	p. 175
Histamine Role in Pathogenesis and Diagnosis of Allergic, Inflammatory, Autoimmune and Cancer Diseases
Histamine: Role in Pathogenesis of Autoimmune, Allergic, Inflammatory and Malignant Diseases	p. 201
Biological Characteristics of Histamine Receptors in Airways Disease Management	p. 227
Histamine Role in Inflammation and Allergy
Mast Cells as a Source and Target for Histamine	p. 247
Histamine H1 Receptor Gene Expression Mechanism as a Novel Therapeutic Target of Allergy	p. 285
Histamine in the Nervous System
The Neuronal Histamine and it's Receptors as New Therapeutic Targets for Food Intake and Obesity	p. 299
Implications of Histaminergic System in Brain Histamine Dysfunction	p. 315
Histamine H3 Receptor: A Target for Momentous Brain Research
Pre-Synaptic Control by Histamine H3 Receptors of Neurotransmitter Release	p. 339
Histamine H4 Receptor: A Noble Target for Inflammatory and Immune Research
Expression of Histamine H4 Receptor in Human Synovial Cells and Dermal Tissues	p. 371
Role of Histamine in Reproductive Function
Novel Role for Histamine Through Classical H1 and H2 Receptors: Regulation of Leydig Cell Steroidogenesis and its Implications for Male Reproductive Function	p. 383
Possible Effect of Histamine in Physiology of Female Reproductive Function: An Updated Review	p. 395
Other Biomedical Aspects of Histamine Agonists, Antagonists, and Inverse Agonists
Histamine Role in Malaria	p. 409
Histamine-Cytokine and Histamine-Antibody Network in Immune Regulation	p. 421
Subject Index	p. 437
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