Biomedical Nanotechnology

by Hurst, Sarah J.

• ISBN13: 9781617790515
• ISBN10: 1617790516
• Format: Hardcover
• Copyright: 2011-04-06
• Publisher: Humana Pr Inc

Summary

Due to their unique size-dependent properties, nanomaterials have the potential to revolutionize the detection, diagnosis, and treatment of disease by offering superior capabilities compared to conventionally-used materials.  Biomedical Nanotechnology: Methods and Protocols brings together experts from a wide variety of fields to provide a practical overview of biomedical nanotechnology, from the conception of novel materials in the laboratory to the application of such structures in the clinic. After a brief introductory chapter, the first section consists of protocol chapters which provide hands-on information on the synthesis of a variety of solution-phase and surface-bound nanomaterials and their application in sensing, imaging, and/or therapeutics, while the second section consists of a series of case studies and review chapters that discuss the toxicology of nanomaterials, the regulatory pathways to US Food and Drug Administration (FDA) approval of these materials, their patenting, marketing, and commercialization, and the legal and ethical issues surrounding their use.  Written in the highly successful Methods in Molecular Biology'„¢ series format, many chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and insightful tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Biomedical Nanotechnology: Methods and Protocols surveys this exciting field from the most vital angles in order to provide a comprehensive reference for scientists and researchers of all different backgrounds looking to utilize the numerous versatile applications of nanomaterial technologies.

Table of Contents

Preface	p. v
Contributors	p. ix
Biomedical Nanotehnology	p. 1
Using Nanomaterials in Sensing, Imaging, and Therapeutics
Multiplexed Detection of Oligonucleotides with Biobarcoded Gold Nanoparticle Probes	p. 17
Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance	p. 33
Real-Time Quantum Dot Tracking of Single Proteins	p. 51
Titanium Dioxide Nanoparticles in Advanced Imaging and Nanotherapeutics	p. 63
Surface Modification and Biomolecule Immobilization on Polymer Spheres for Biosensing Applications	p. 77
Multivalent Conjugation of Peptides, Proteins, and DNA to Semiconductor Quantum Dots	p. 95
A Single Sno2 Nanowire-Based Microelectrode	p. 111
Biosensing Using Nanoelectromechanical Systems	p. 119
Nano ôFly Paperö Technology for the Capture of Circulating Tumor Cells	p. 141
Polymeric Nanoparticles for Photodynamic Therapy	p. 151
Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles	p. 179
Antibacterial Application of Engineered Bacteriophage Nanomedicines: Antibody-Targeted, Chloramphenicol Prodrug Loaded Bacteriophages for Inhibiting the Growth of Staphylococcus aureus Bacteria	p. 187
Viruses as Nanomaterials for Drug Delivery	p. 207
Applications of Carbon Nanotubes in Biomedical Studies	p. 223
Electrospun Nanofibrous Scaffolds for Engineering Soft Connective Tissues	p. 243
Peptide Amphiphiles and Porous Biodegradable Scaffolds for Tissue Regeneration in the Brain and Spinal Cord	p. 259
Computational Simulations of the Interaction of Lipid Membranes with DNA-Functionalized Gold Nanoparticles	p. 283
Translating Nanoscience and Technology from the Lab to the Clinic
Cytotoxic Assessment of Carbon Nanotube Interaction with Cell Cultures	p. 299
Nanoparticle Toxicology: Measurements of Pulmonary Hazard Effects Following Exposures to Nanoparticles	p. 313
Nanoparticle Therapeutics: FDA Approval, Clinical Trials, Regulatory Pathways, and Case Study	p. 325
Legislating the Laboratory? Promotion and Precaution in a Nanomaterials Company	p. 339
Navigating the Patent Landscapes for Nanotechnology: English Gardens or Tangled Grounds?	p. 359
Scientific Entrepreneurship in the Materials and Life Science Industries	p. 379
Applying the Marketing Mix (5 Ps) to Bionanotechnology	p. 393
Managing the ôKnown Unknownsö: Theranostic Cancer Nanomedicine and Informed Consent	p. 413
Index	p. 431
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