Biomedical Optics Principles and Imaging

by Wang, Lihong V.; Wu, Hsin-i

• ISBN13: 9780471743040
• ISBN10: 0471743046
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-05-29
• Publisher: Wiley-Interscience

Summary

This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues will be covered. The imaging modalities will include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging.  The basic physics and engineering of each imaging technique will be emphasized. 

Author Biography

Lihong V. Wang, PhD, is Gene K. Beare Distinguished Professor in the Department of Biomedical Engineering and Director of the Optical Imaging Laboratory at Washington University in St. Louis. Dr. Wang is Chair of the International Biomedical Optics Society. His?Monte Carlo model of photon transport in biological tissues has been used worldwide. He has published more than 120 peer-reviewed journal articles and patents.

HSIN-I WU, PhD, is Professor of Biomedical Engineering at Texas A&M University. He has published more than fifty peer-reviewed journal articles. Dr. Wu was a senior Fulbright scholar and is listed in Outstanding Educators of America. He serves on the Editorial Advisory Board of Biocomplexity and the Editorial Board of BioMedical Engineering OnLine.

Table of Contents

Preface

Introduction

Motivation for optical imaging

General behavior of light in biological tissue

Basic physics of light-matter interaction

Absorption and its biological origins

Scattering and its biological origins

Polarization and its biological origins

Fluorescence and its biological origins

Image characterization

References

Further readings

Problems

Rayleigh Theory And Mie Theory For A Single Scatterer

Introduction

Summary of the Rayleigh theory

Numerical example of the Rayleigh theory

Summary of the Mie theory

Numerical example of the Mie theory

Appendix 2.A

Appendix 2.B

References

Further readings

Problems

Monte Carlo Modeling Of Photon Transport In Biological Tissue

Introduction

Monte Carlo method

Definition of problem

Propagation of photons

Physical quantities

Computational examples

Appendix 3.A

Appendix 3.B

References

Further readings

Problems

Convolution For Broadbeam Responses

Introduction

General formulation of convolution

Convolution over a Gaussian beam

Convolution over a top-hat beam

Numerical solution to convolution

Computational examples

Appendix 4.A

References

Further readings

Problems

Radiative Transfer Equation And Diffusion Theory

Introduction

Definitions of physical quantities

Derivation of the radiative transport equation

Diffusion theory

Boundary conditions

Diffuse reflectance

Photon propagation regimes

References

Further readings

Problems

Hybrid Model Of Monte Carlo Method And Diffusion Theory

Introduction

Definition of problem

Diffusion theory

Hybrid model

Numerical computation

Computational examples

References

Further readings

Problems

Sensing Of Optical Properties And Spectroscopy

Introduction

Collimated transmission method

Spectrophotometry

Oblique-incidence reflectometry

White-light spectroscopy

Time-resolved measurement

Fluorescence spectroscopy

Fluorescence modeling

References

Further readings

Problems

Ballistic Imaging And Microscopy

Introduction

Characteristics of ballistic light

Time-gated imaging

Spatial-frequency filtered imaging

Polarization-difference imaging

Coherence-gated holographic imaging

Optical heterodyne imaging

Radon transformation and computed tomography

Confocal microscopy

Two-photon microscopy

Appendix 8.A. Holography

References

Further readings

Problems

Optical Coherence Tomography

Introduction

Michelson interferometry

Coherence length and coherence time

Time-domain OCT

Fourier-domain rapid scanning optical delay line

Fourier-domain OCT

Doppler OCT

Group velocity dispersion

Monte Carlo modeling of OCT

References

Further readings

Problems

Mueller Optical Coherence Tomography

Introduction

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