Biomimetic Organic Synthesis, 2 Volume Set

by Poupon, Erwan; Nay, Bastien

• ISBN13: 9783527325801
• ISBN10: 3527325808
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-06-07
• Publisher: Wiley-VCH

Summary

In this first book on the topic, important key definitions and general concepts will be provided in a tutorial way. Natural product synthesis will be classified according to main biosynthetic pathways (e.g. terpenes, alkaloids, polyketides). A focus will be the biomimetic efforts towrds the total synthesis of natural products.Key features include:- Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming and there is a definite need for this book. - Unifying both synthetic and biosynthetic aspects this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry. - Over 248000 hits in Google on Biomimetic Synthesis and 2000 hits in ISI Web of Knowledge.

Author Biography

Erwan Poupon is a pharmacist, he obtained his PhD in organic chemistry under the supervision of Dr. Nicole Kunesch and Prof. Henri-Philippe Husson in 2000 at Paris-Descartes University. He was subsequently a post-doctoral fellow at the University of California at San Diego working with Prof. Emmanuel Theodorakis. He then joined the faculty at the School of Pharmacy of Paris-Sud University where he is now Professor of pharmacognosy and natural product chemistry. His fields of interest relate to the chemistry of natural products, including biomimetic synthesis and chemical biology.

Bastien Nay obtained his diploma of Pharmacy in 1998 and his PhD in organic chemistry in 2000 under the guidance of Prof. Joseph Vercauteren at the School of Pharmacy of Bordeaux, France. He then joined Prof. J. Stephen Clark's group as a post-doctoral fellow at the University of Nottingham, UK. In 2003 he was appointed research scientist at the CNRS, now working and teaching at the National Museum of Natural History in Paris, where he is managing the natural product chemistry team. His research interests non only concern the synthetic strategies towards natural products, but also their origin and raion d'?tre.

Table of Contents

Foreword

Introduction

Biomimetic Chemistry, Biomimetic Synthesis

On the Structure of the Book: Reading Guidelines

Biomimetic Synthesis of Terpenoids and Polyprenylated Natural Compounds

Key Biosynthesis Elements

Isoprenoid Polyene Electrophilic Cyclizations

Complex Terpenoids from Rearrangements

Polyprenylated Xanthones and Phloroglucinols

Biomimetic Synthesis of Polyketides

Key Biosynthetic Elements

Polyketide Assembly Mimics and Biomimetic Access to Aromatic Rings

Polycyclic Aliphatic Polyketides

Biomimetic Polyepoxide Openings, Polyether Natural Substances

Biomimetic Electrocyclizations towards Polyketides

Biomimetic Total Synthesis of Alkaloids

Key Biosynthesis Elements

Alkaloids Derived from Ornithine and Lysine

Alkaloids Derived from Tyrosine

Alkaloids Derived from Tryptophan: Indolomonoterpenic Alkaloids

Alkaloids Derived from Tryptophan: Diketopiperazine Alkaloids

Alkaloids Derived from Tryptophan: Miscellaneous Indole Alkaloids

Biomimetic Synthesis of Marine Manzamine-Type Alkaloids

Biomimetic Synthesis of Marine Pyrrole-Imidazole and Guanidinium Alkaloids

Alkaloids Derived by Amination

Miscellaneous Natural Products

Miscellaneous Biomimetic Syntheses of Natural Products

Artifacts: Natural Substances Formed Spontaneously

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