Biotherapeutic Agents and Infectious Diseases

by Elmer, Gary W.; McFarland, Lynne V.; Surawicz, Christina M.

• ISBN13: 9780896036475
• ISBN10: 0896036472
• Format: Hardcover
• Copyright: 1999-01-01
• Publisher: Humana Pr Inc

Summary

Authoritative investigators active in the discovery, development, and application of biological anti-infective agents concisely review their use and potential in preventing and treating human disease. Focusing on biotherapeutic entities that have been tested in controlled studies, the prominent experts illuminate the scientific underpinnings of their therapeutic power, assess their possible risks in the treatment of infectious diseases, and outline the research needed to better define their effectiveness. In addition, they also consider how biotherapeutic agents may be genetically engineered for maximum intestinal and vaginal production of bioactive substances in vivo. Biotherapeutic Agents and Infectious Diseases brings together all the evidence needed to understand and capitalize on the considerable promise of this significant new class of biotherapeutic entities.

Table of Contents

Preface	v	(6)
Contributors	xi
1 Quality Control and Regulatory Issues for Biotherapeutic Agents	1	(26)
Lynne V. McFarland
2 Mechanisms of Action of Biotherapeutic Agents	27	(20)
Jean-Paul Buts
3 Pharmacokinetics of Biotherapeutic Agents	47	(38)
Steven W. Martin
Anne C. Heatherington
Gary W. Elmer
4 Influences on the Normal Microbial Flora	85	(36)
Kerstin Orrhage
Carl Erik Nord
5 Immunological Effects of Biotherapeutic Agents	121	(24)
Phillippe Marteau
Christophe Cellier
6 Biotherapeutic Agents in the Prevention of Antibiotic-Associated Diarrhea	145	(14)
Christina M. Surawicz
7 Biotherapeutic Agents for Clostridium difficile-Associated Disease	159	(36)
Lynne V. McFarland
8 Biotherapeutic Agents in the Management of Pediatric Diarrheal Disease	195	(12)
Jose M. Saavedra
9 Biotherapeutic Agents and Adult Diarrhea	207	(14)
S. Salminen
E. Isolauri
E. Salminen
10 Biotherapeutic Agents as Therapy for Vaginitis	221	(24)
J. D. Sobel
11 Biotherapeutic Agents to Prevent Cystitis in Women	245	(18)
Gregor Reid
Vladimir Smeianov
Andrew W. Bruce
12 Risks of Biotherapeutic Agents	263	(6)
Christina M. Surawicz
Lynne V. McFarland
13 Future Directions for Research on Biotherapeutic Agents: Contribution of Genetic Approaches on Lactic Acid Bacteria	269	(36)
Gerard Corthier
Pierre Renault
Index	305