Blood and Bone Marrow Pathology

This book will be the most complete and authoritative benchside reference text on the pathologic interpretation and diagnosis of blood and bone marrow disease. The book will cover all of the pathologic conditions that are likely to be encountered in daily practice. The text incorporate the latest knowledge on the molecular basis of inherited red cell and coagulation disorders. The organizational structure of each chapter will follow a consistent format: incidence/epidemiology, pathogenesis, brief clinical presentation, histologic and cytologic appearance, testing techniques, differential diagnosis and a brief section on clinical behavior and outcome. Detailed descriptions of the pathologic features of blood and bone marrow in combination with over 1,000 high quality illustrations provide the reader with a single, comprehensive resource to assist in accurate diagnosis. Histologic and cytologic appearances are correlated throughout to provide the clinician with a complete and integrated approach to diagnostic interpretation and reporting. An emphasis on differential diagnosis and diagnostic pitfalls provides the clinician with a quick, practical solution to reporting difficult and problematic specimens. Focus on the practical techniques of diagnostic laboratory testing reflects the realities of the pathologist's everyday work environment. Consistent and logical organizational structure will enable the clinician to locate essential information quickly and easily.

Preface

vii

List of contributors

ix

SECTION 1 Normal blood and bone marrow cells

Normal blood cells

3

(20)

S.N. Wickramasinghe

Normal bone marrow cells: development, cytology and ultrastructure

23

(30)

S.N. Wickramasinghe

Normal bone marrow: histology, histochemistry and immunohistochemistry

53

(18)

R. Bartl

B. Frisch

Regulation of hematopoiesis

71

(18)

C. Verfaillie

SECTION 2 Pathology of the marrow

General considerations

89

(42)

S.N. Wickramasinghe

B.J. Bain

SECTION 3 Disorders affecting erythroid cells

Investigation and classification of anemia

131

(10)

S.N. Wickramasinghe

Abnormalities of the red cell membrane

141

(8)

J. Delaunay

Erythroenzyme disorders

149

(10)

D.M. Layton

D.R. Roper

Abnormalities of the structure and synthesis of hemoglobin

159

(26)

S.L. Thein

Acquired hemolytic anemias

185

(18)

J.G. Kelton

H. Chan

N. Heddle

S. Whittaker

Iron deficiency anemia, anemia of chronic disorder and iron overload

203

(26)

M.J. Pippard

Macrocytic anemia

229

(20)

S.N. Wickramasinghe

Aplastic anemia

249

(16)

E.C. Gordon-Smith

Pure red cell aplasia and sideroblastic anemias

265

(8)

S.N. Wickramasinghe

Congenital dyserythropoietic anemias

273

(10)

S.N. Wickramasinghe

Polycythemia (the erythrocytoses)

283

(16)

M. Messinezy

J.D. van der Walt

T.C. Pearson

SECTION 4 Disorders affecting leukocyte lineages

Abnormalities in leucocyte morphology and number

299

(22)

S.N. Wickramasinghe

Disorders of phagocyte function

321

(10)

J.R. Brown

A.J. Thrasher

Myelodysplastic disorders

331

(20)

T.J. Hamblin

B.S. Wilkins

Acute leukemias

351

(30)

D.M. Swirsky

S.J. Richards

P.A.S. Evans

The chronic lymphoid and myeloid leukemias and systemic mastocytosis

381

(24)

D.M. Clark

B.J. Bain

Lymphoma

405

(32)

B.S. Wilkins

D. Oscier

Abnormalities in immunoglobulin synthesising cells

437

(36)

F. Davies

K. Anderson

SECTION 5 Abnormalities of hemostasis

Hemostasis: principles of investigation

473

(20)

D.H. Bevan

Disorders affecting megakarocytes and platelets: inherited conditions

493

(32)

J.G. White

Acquired disorders affecting megakaryocytes and platelets

525

(32)

D. Provan

A.C. Newland

Inherited disorders of coagulation

557

(20)

C.A. Lee

Acquired bleeding disorders

577

(22)

D.J. Perry

Natural anticoagulants and thrombophilia

599

(16)

M.A. Laffan

SECTION 6 Immunohematology

Blood groups on red cells, platelets and neutrophils

615

(22)

G. Daniels

A. Hadley

Transfusion medicine for pathologists

637

(28)

J. McCullough

Histocompatibility: HLA and other systems

665

(44)

P.E. Posch

R.J. Hartzman

C.K. Hurley

Index

709

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