Blood Perfusion and Microenvironment of Human Tumors: Implications for Clinical Radiooncology

by Molls, M.; Vaupel, Peter; Brady, Luther W.; Heilmann, H. P.

• ISBN13: 9783540669944
• ISBN10: 3540669949
• Edition: 1st
• Format: Paperback
• Copyright: 2000-06-01
• Publisher: Springer Verlag

Summary

This text explores the most recent advances in research on adaptations and responses to the physical environment among the major plant groups found in tropical ecosystems. Fundamental processes provide the organizational framework for the book. Its four main sections include: i) acquisition, transport and loss of water, ii) carbon acquisition and regulation of photosynthetic gas exchange, iii) nutrient acquisition and use, iv) energy balance and adaptation to temperature extremes. Concise but informative explanations of fundamental concepts at the beginning of each chapter allow those not familiar with the spcialized terminology to grasp the nuances of each topic before becoming immersed in the more detailed analyses processes and case studies taht follow. The book ends by suggesting that the bewildering plant species diversity in tropical ecosystems does not necessarily reflect an intractable range of physiological diversity.

Table of Contents

The Impact of the Tumor Microenvironment on Experimental and Clinical Radiation Oncology and Other Therapeutic Modalities	p. 1
Morphological Aspects of Tumor Angiogenesis and Microcirculation	p. 5
The Role of the Microcirculation in the Treatment of Malignant Tumors: Facts and Fiction	p. 19
Tumor Blood Flow	p. 41
Clinical Investigations on Blood Perfusion in Human Tumors	p. 47
Oxygenation of Human Tumors	p. 63
The Prognostic Significance of Hypoxia in Cervical Cancer: A Radiobiological or Tumor Biological Phenomenon?	p. 73
Changes in Tumor Oxygenation During Radiation Therapy	p. 81
Misonidazole Labeling as a Marker of Cellular Hypoxia	p. 89
Significance of Hemoglobin Concentration for Treatment Outcome	p. 101
Tumour pH	p. 113
Energy Status of Malignant Tumors in Patients and Experimental Animals	p. 121
Therapeutic Significance of Microenvironmental Factors	p. 133
Application of Nuclear Magnetic-Resonance for Investigation of the Tumour Microenvironment	p. 145
The Potential Role of Positron Emission Tomography in Investigation of the Microenvironment	p. 161
Modification of Blood Flow	p. 193
Modification of Oxygen Supply	p. 209
The Potential Benefit of Hypoxic Cytotoxins in Radio-Oncology	p. 219
Subject Index	p. 231
List of Contributors	p. 237
Table of Contents provided by Blackwell. All Rights Reserved.