Bone Marrow Pathology

by Bain, Barbara J.; Clark, David M.; Wilkins, Bridget S.

• ISBN13: 9781444309782
• ISBN10: 1444309781
• Edition: 4th
• Format: eBook
• Copyright: 2009-11-26
• Publisher: Wiley-Blackwell

Summary

Bone Marrow Pathology has been extensively revised to reflect the significant advances which have occurred in the application of cytogenetics and in particular, molecular genetics in the diagnosis, classification and understanding of haematological disorders. This comprehensive book not only provides information on all common disease entities, but also covers rare disorders in which bone marrow examination is useful. It is designed as practical resource with ‘Problems and Pitfalls’ sections throughout to aid laboratory diagnosis.

This fourth edition:

• Incorporates the recommendations of the 2008 WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
• Covers key diagnostic techniques such as flow cytometric immunophenotyping, immunohistochemistry and cytogenetic and molecular genetic analysis
• Includes new diagnostic algorithms and summary boxes
• Contains 550 colour illustrations including high-quality digital photomicrographs 

Haematologists and histopathologists will find this book an invaluable desktop reference when performing daily blood and bone marrow investigations.

Author Biography

Barbara J. Bain, MBBS, FRACP, FRCPath
Professor of Diagnostic Haematology, St Mary's Hospital Campus of Imperial College, Faculty of Medicine, Imperial College, London and Honorary Consultant Haematologist, St Mary's Hospital, London, UK

David M. Clark, MD, MRCP(UK), FRCPath
Consultant Histopathologist, Path Links, N Lincolnshire and Goole Hospitals NHS Foundation Trust; Honorary Consultant Histopathologist, Nottingham University Hospitals, and Special Lecturer in Pathology, University of Nottingham, UK

Bridget S. Wilkins, DM, PhD, FRCPath
Consultant in Haematopathology, Guy's and St Thomas' Hospitals NHS Foundation Trust, London; Honorary Senior Lecturer in Haematopathology, King's College, London

Table of Contents

Preface to the fourth edition, vi

Acknowledgements, vii

Abbreviations, viii

1 The normal bone marrow, 1

2 Special techniques applicable to bone marrow diagnosis, 54

3 Infection and reactive changes, 100

4 Acute myeloid leukaemia, mixed phenotype acute leukaemia, the myelodysplastic syndromes and histiocytic neoplasms, 166

5 Myeloproliferative and myelodysplastic/myeloproliferative neoplasms and related conditions, 239

6 Lymphoproliferative disorders, 300

7 Plasma cell neoplasms, 421

8 Disorders of erythropoiesis, granulopoiesis and thrombopoiesis, 461

9 Miscellaneous disorders, 500

10 Metastatic tumours, 549

11 Diseases of bone, 587

Appendix, 601

Index, 611