Brain Edema XI

by Mendelow, A. D.

• ISBN13: 9783211835616
• ISBN10: 321183561X
• eBook ISBN(s): 9783709163467
• Format: Hardcover
• Copyright: 2001-12-01
• Publisher: Springer Verlag
• More Book Details
• Purchase Benefits

Summary

Brain edema is found in a wide variety of clinical disorders including stroke, intracerebral haemorrhage, subarachnoid haemorrhage, head injury, brain tumors and hydrocephalus.This volume brings together clinical and basic scientists from all over the world. Their expertise in the understanding of brain edema and shifts in brain water compartments has led to a further significant step in our understanding of those diseases characterized by brain edema. This book has also drawn on the expertise of the International Advisory Board of the Brain Edema Society, who have carefully summarized each section, thus providing an easy-to-read summary of the latest advances in each subject. The book is therefore much more than a collection of papers: it represents a critical appraisal and puts each paper into modern scientific context.The greatest advances have come from the rapid development of modern imaging techniques, especially with magnetic resonance imaging (MRI). Imaging can now produce 'œwater maps' and 'œmetabolic profiles' that bring brain metabolism and water content right into every clinic with access to MRI.This book provides the background knowledge to understand these pathophysiological changes.

Table of Contents

Imaging	1	(27)
H-MR Spectroscopic Monitoring of Posttraumatic Metabolism Following Controlled Cortical Impact Injury: Pilot Study	1	(8)
M. U. Schuhmann
D. Stiller
S. Thomas
T. Brinker
M. Samii
Heterogeneous Mechanisms of Early Edema Formation in Cerebral Contusion: Diffusion MRI and ADC Mapping Study	9	(4)
T. Kawamata
Y. Katayama
N. Aoyama
T. Mori
Metabolic Changes in Pericontusional Oedematous Areas in Mild Head Injury Evaluated by 1H MRS	13	(4)
B. C. Son
C. -K. Park
B. -G. Choi
E. -N. Kim
B.-Y. Choe
K. -S. Lee
M.-C. Kim
J.-K. Kang
Malignancy of Brain Tumors Evaluated by Proton Magnetic Resonance Spectroscopy (1H-MRS) in Vitro	17	(4)
Z. Czernicki
D. Horsztynski
W. Jankowski
P. Grieb
J. Walecki
rCBF in Hemorrhagic, Non-Hemorrhagic and Mixed Contusions After Severe Head Injury and its Effect on Perilesional Cerebral Blood Flow	21	(6)
B. M. Hoelper
M. M. Reinert
A. Zauner
E. Doppenberg
R. Bullock
Molecular Mechanisms	27	(88)
Glutathione Homeostasis and Leukotriene-Induced Permeability in Human Blood-Brain Barrier Endothelial Cells Subjected to in Vitro Ischemia	29	(6)
A. Muruganandam
C. Smith
R. Ball
T. Herring
D. Stanimirovic
Comparison of NAA Measures by MRS and HPLC	35	(4)
P. P. Fatouros
D. L. Heath
A. Beaumont
F. D. Corwin
S. Signoretti
R. H. AL-Samsam
B. Alessandri
P. Lazzarino
R. Vagnozzi
B. Tavazzi
R. Bullock
A. Marmarou
Influence of the Bradykinin B1/B2-Receptor-Antagonist B 9428 on the Cerebral Microcirculation and Outcome of Gerbils from Global Cerebral Ischemia	39	(4)
J. Lehmberg
J. Beck
A. Baethmann
E. Uhl
Evolution of Energy Failure after Repeated Cerebral Ischemia in Gerbils	43	(4)
T. Kuroiwa
U. Ito
Y. Hakamata
S. Hanyu
G. Mies
D. Hermann
Indomethacin and Cyclosporin a Inhibit in Vitro Ischemia-Induced Expression of ICAM-1 and Chemokines in Human Brain Endothelial Cells	47	(8)
W. Zhang
C. Smith
R. Monette
J. Hutchison
D. B. Stanimirovic
The Selectin Superfamily: The Role of Selectin Adhesion Molecules in Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage	55	(6)
J. J. Nissen
D. Mantle
A. Blackburn
J. Barnes
T. Wooldridge
B. Gregson
A. D. Mendelow
Traumatic Brain Injury in Mice Deficient in Poly-ADP(Ribose) Polymerase: A Preliminary Report	61	(4)
M. J. Whalen
R. S. B. Clark
C. E. Dixon
P. Robichaud
D. W. Marion
V. Vagni
S. Graham
L. Virag
G. Hasko
R. Stachlewitz
C. Szabo
P. M. Kochanek
Increased Immunolocalization of Nitric Oxide Synthases During Blood-Brain Barrier Breakdown and Cerebral Edema	65	(4)
S. Nag
P. Picard
D. J. Stewart
Biological Functions of Extravasated Serum IgG in Rat Brain	69	(4)
E. Kadota
Y. Muramatsu
K. Nonaka
M. Karasuno
K. Nishi
K. Dote
S. Hashimoto
Possible Reverse Transport of β-Amyloid Peptide Across the Blood-Brain Barrier	73	(6)
R. Pluta
A. Misicka
M. Barcikowska
S. Spisacka
A. W. Lipkowski
S. Januszewski
Reducing Conditions Produce a Loss of Neuroprotective Efficacy of Competitive but not Non-Competitive Antagonists in a Model of NMDA-Mediated Excitotoxicity in Organotypic Hippocampal Slice Cultures	79	(2)
A. K. Pringle
J. Self
F.Iannotti
Role of Nitric Oxide in Blood-Brain Barrier Permeability, Brain Edema and Cell Damage Following Hyperthermic Brain Injury. An Experimental Study Using EGB-761 and Gingkolide B Pretreatment in the Rat	81	(6)
H. S. Sharma
K. Drieu
P. Alm
J. Westman
Extracts of Ginkgo Biloba and Panax Ginseng Protect Brain Proteins from Free Radical Induced Oxidative Damage in Vitro	87	(4)
M. S. Siddique
F. Eddeb
D. Mantle
A. D. Mendelow
p-Chlorophenylalanine, an Inhibitor of Serotonin Synthesis Reduces Blood-Brain Barrier Permeability, Cerebral Blood Flow, Edema Formation and Cell Injury Following Trauma to the Rat Brain	91	(6)
H. S. Sharma
T. Winkler
E. Stalberg
S. Mohanty
J. Westman
S-100 Serum Levels and Outcome After Severe Head Injury	97	(4)
R. D. Rothoerl
C. Woetgen
A. Brawanski
A Microstructural Study of Spinal Cord Edema	101	(4)
H. Naruse
K. Tanaka
A. Kim
Vasogenic Oedema and Brain Infarction in an Experimental Penumbra Model	105	(6)
M. Haseldonckx
D. van Bedaf
M. van de Ven
J. van Reempts
M. Borgers
Effects of Chronic Deep Hypoxia on the Expression of Nitric Oxide Synthase in the Rat Brain	111	(4)
J. V. Lafuente
B. Adan
J. Cervos-Navarro
Cellular Mechanisms	115	(70)
Adrenergic Mediation of TNFα-Stimulated ICAM-1 Expression on Human Brain Microvascular Endothelial Cells	117	(4)
Y. Ohara
R. M. McCarron
T. T. Hoffman
H. Sugano
J. Bembry
F. A. Lenz
M. Spatz
Time Course of Apoptotic Cell Death After Experimental Neurotrauma	121	(4)
M. Barth
L. Schilling
P. Schmiedek
The Permissive Nature of Blood Brain Barrier (BBB) Opening in Edema Formation Following Traumatic Brain Injury	125	(6)
A. Beaumont
A. Marmarou
K. Hayasaki
P. Barzo
P. Fatouros
F. Corwin
C. Marmarou
J. Dunbar
Endothelin-1 and Nitric Oxide Affect Human Cerebromicrovascular Endothelial Responses and Signal Transduction	131	(6)
Y. Chen
C. R. M. McCarron
N. Azzam
J. Bembry
C. Reutzler
F. A. Lenz
M. Spatz
LF16-0687 A Novel Non-Peptide Bradykinin B2 Receptor Antagonist Reduces Vasogenic Brain Edema from a Focal Lesion in Rats	137	(4)
J. Schulz
N. Plesnila
J. Eriskat
M. Stoffel
D. Pruneau
A. Baethmann
AT1 Receptor Antagonist Prevents Brain Edema Without Lowering Blood Pressure	141	(6)
H. Ito
K. Takemori
J. Kawai
T. Suzuki
The Effects of Dopamine on Edema Formation in two Models of Traumatic Brain Injury	147	(6)
A. Beaumont
K. Hayasaki
A. Marmarou
P. Barzo
P. Fatouros
F. Corwin
A New Antioxidant Compound H-290/51 Attenuates Upregulation of Constitutive Isoform of Heme Oxygenase (HO-2) Following Trauma to the Rat Spinal Cord	153	(6)
H. S. Sharma
P. Alm
P.-O. Sjoquist
J. Westman
A Bradykinin BK2 Receptor Antagonist HOE-140 Attenuates Blood-Spinal Cord Barrier Permeability Following a Focal Trauma to the Rat Spinal Cord	159	(6)
H. S. Sharma
Combined Therapy Utilizing a Novel Na+/H+ Exchange Inhibitor (SM-20220) and THAM for Ischemic Brain Edema	165	(6)
Y. Hakamata
U. Ito
T. Kuroiwa
S. Hanyu
N. Ohashi
I. Nakano
Bradykinin 2 Receptor Antagonist LF 16-0687 Ms Reduces Posttraumatic Brain Edema	171	(6)
J. F. Stover
N. -K. Dohse
A. W. Unterberg
Influence of Alcohol Exposure on S-100b Serum Levels	177	(4)
P. Biberthaler
T. Mussack
E. Wiedemann
K. G. Kanz
T. Gilg
C. Gippner-Steppert
M. Jochum
Laser Doppler Scanning: How Many Measurements are Required to Assess Regional Cerebral Blood Flow?	181	(4)
M. Soehle
A. Heimann
O. Kempski
Experimental Studies/Models	185	(52)
Assessment of 2-Chloroadenosine Treatment After Experimental Traumatic Brain Injury in the Rat Using Arterial Spin-Labeled MRI: A Preliminary Report	187	(4)
C. L. Robertson
K. S. Hendrich
P. M. Kochanek
E. K. Jackson
J. A. Melick
S. H. Graham
D. W. Marion
D. S. Williams
C. Ho
Time Course of Trace of Diffusion Tensor [Trace(D)] and Histology in Brain Edema	191	(4)
T. Kuroiwa
T. Nagaoka
N. Miyasaka
H. Akimoto
F. Zhao
I. Yamada
M. Ueki
S. Ichinose
L-Histidine but not D-Histidine Attenuates Brain Edema Following Cryogenic Injury in Rats	195	(4)
Y. Ikeda
Y. Mochizuki
H. Matsumoto
Y. Nakamura
K. Dohi
H. Jimbo
M. Shimazu
M. Hayashi
K. Matsumoto
Oxygen Delivery and Oxygen Tension in Cerebral Tissue During Global Cerebral Ischaemia A Swine Model	199	(4)
S. Rossi
M. Balestreri
D. Spagnoli
G. Bellinzona
V. Valeriani
P. Bruzzone
M. Maestri
N. Stocchetti
ICP and MABP Following Traumatic Subarachnoid Hemorrage in the Rat	203	(4)
S. Thomas
F. Tabibnia
M. U. Schuhmann
T. Brinker
M. Samii
Real Time Monitoring of Glutamate Following Fluid Percussion Brain Injury with Hypoxia in the Rat	207	(6)
Y. Matsushita
K. Shima
H. Nawashiro
K. Wada
N. Tsuzuki
T. Miyazawa
The Synergistic Effect of Acute Subdural Hematoma Combined with Diffuse Traumatic Brain Injury on Brain Edema	213	(4)
Y. Tomita
S. Sawauchi
A. Beaumont
A. Marmarou
Mitogen-Activated Protein Kinase Plays an Important Role in Hemolysate-Induced Contraction in Rabbit Basilar Artery	217	(6)
A. Y. Zubkov
K. Ogihara
A. Patllola
A. D. Parent
J. Zhang
Morphological Presentation of Posttraumatic Vasospasm	223	(4)
A. Y. Zubkov
A. S. Pilkington
A. D. Parent
J. Zhang
Role of Tyrosine Kinase in Fibroblast Compaction and Cerebral Vasospasm	227	(4)
A. Patlolla
K. Ogihara
A. Zubkov
K. Aoki
A. D. Parent
J. H. Zhang
Toxin-Induced Vasogenic Cerebral Oedema in a Rat Model	231	(6)
M. N. Ghabriel
C. Zhu
P. L. Reilly
P. C. Blumbergs
J. Manavis
J. W. Finnie
Experimental Ischaemia	237	(46)
Expression of Water Channel mRNA Following Cerebral Ischemia	239	(4)
S. Sato
F. Umenishi
G. Inamasu
M. Sato
M. Ishikawa
M. Nishizawa
T. Oizumi
Brain Oxygen Tension During Hyperoxia in a Swine Model of Cerebral Ischaemia	243	(4)
S. Rossi
L. Longhi
M. Balestreri
D. Spagnoli
A. deLeo
N. Stocchetti
The Synergistic Effect of High K+ and Hypoxia on Extracellular Concentrations of Neuroactive Amino Acid in Hippocampus	247	(4)
Y. Matsushita
K. Shima
H. Katoch
H. Nawashiro
Spreading Depression Induces Permanent Cell Swelling Under Penumbra Conditions	251	(6)
O. Kempski
H. Otsuka
T. Seiwert
A. Heimann
Cerebral Blood Flow and the Secondary Growth of Brain Tissue Necrosis After Trauma	257	(4)
D. H. Friedrich
N. Plesnila
J. Eriskat
M. Stoffel
A. Baethmann
The Role of Proteolytic Enzymes in Focal Ischaemic Brain Damage	261	(4)
M. Davis
D. Mantle
A. D. Mendelow
Effect of Intracerebral Lesions Detected in Early MRI on Outcome After Acute Brain Injury	265	(4)
B. M. Hoelper
F. Soldner
L. Chone
T. Wallenfang
Effects of Brain Oedema in the Measurement of Ischaemic Brain Damage in Focal Cerebral Infarction	269	(4)
C.-K. Park
S.-G. Kang
Characterizing Edema Associated with Cortical Contusion and Secondary Insult Using Magnetic Resonance Spectroscopy	273	(4)
G. Portella
A. Beaumont
F. Corwin
P. Fatouros
A. Marmarou
Plasminogen Activator Inhibitor-1 in Patients with Ischemic Stroke	277	(2)
E. Haapaniemi
T. Tatlisumak
L. Soinne
M. Syrjala
M. Kaste
Experimental Study on Brain Oxygenation in Relation to Tissue Water Redistribution and Brain Oedema	279	(4)
E. Titovets
N. Nechipurenko
T. Griboedova
P. Vlasyuk
Pharmacology/Therapy	283	(64)
Mn-SOD and Bcl-2 Expression After Repeated Hyperbaric Oxygenation	285	(6)
K. Wada
T. Miyazawa
N. Nomura
A. Yano
N. Tsuzuki
H. Nawashiro
K. Shima
Neurotrophic Factors Attenuate Alterations in Spinal Cord Evoked Potentials and Edema Formation Following Trauma to the Rat Spinal Cord	291	(6)
T. Winkler
H. S. Sharma
E. Stalberg
R. D. Badgaiyan
Spinal Cord Injury Induced c-fos Expression is Reduced by p-PCA, a Serotonin Synthesis Inhibitor. An Experimental Study Using Immunohistochemistry in the Rat	297	(6)
H. S. Sharma
J. Westman
T. Gordh
F. Nyberg
Lipocortin-1 Fails to Ameliorate Ischemic Brain Edema in the Cat	303	(4)
T. Mima
T. Shigeno
Lipocortin-1 Fails to Ameliorate Cold-Injury Brain Edema in the Rat	307	(4)
T. Mima
T. Shigeno
Hepatocyte Growth Factor Reduces Infarct Volume After Transient Focal Cerebral Ischemia in Rats	311	(6)
N. Tsuzuki
T. Miyazawa
K. Matsumoto
T. Nakamura
K. Shima
H. Chigasaki
Clinical Use of Lidocaine for Control of Stroke Oedema in the Posterior Cranial Fossa Accompanied by Acute Hydrocephalus	317	(6)
A. Hirayama
S. Yamasaki
M. Miyata
Usefulness of Niravoline, an Arginine Vasopressin Inhibitor, on Tumour-Origin Brain Oedema	323	(6)
H. Takahashi
H. Hamada
A. Teramoto
Broad-Spectrum Cation Channel Inhibition by LOE 908 MS Reduces Infarct Volume in Vivo and Postmortem in Focal Cerebral Ischemia in the Rat	329	(2)
T. Tatlisumak
R. A. D. Carano
K. Takano
M. R. Meiler
F. Li
C. H. Sotak
U. Pschorn
M. Fisher
A Glycine Site Antagonist ZD9377 Reduces Number of Spreading Depressions and Infarct Size in Rats with Permanent Middle Cerebral Artery Occlusion	331	(4)
T. Tatlisumak
K. Takano
M. R. Meiler
M. Fisher
Effects of Inducible Nitric Oxide Synthase Inhibition on Cerebral Edema in Severe Hypertension	335	(4)
K. Takemori
H. Ito
T. Suzuki
Sphingolipid Biosynthesis by L-PDMP After Rat MCA Occlusion	339	(4)
M. Kubota
M. Nakane
T. Nakagomi
A. Tamura
H. Hisaki
N. Ueta
J. Inokuchi
A. Hirayama
Protective Effect of a Novel Vitamin E Derivative on Experimental Traumatic Brain Edema in Rats - Preliminary Study	343	(4)
Y. Ikeda
Y. Mochizuki
Y. Nakamura
K. Dohi
H. Matsumoto
H. Jimbo
M. Hayashi
K. Matsumoto
T. Yoshikawa
H. Murase
K. Sato
Head Injury	347	(76)
Distinguishing Between Cellular and Vasogenic Edema in Head Injured Patients with Focal Lesions Using Magnetic Resonance Imaging	349	(4)
A. Marmarou
G. Portella
P. Barzo
S. Signoretti
P. Fatouros
A. Beaumont
T. Jiang
R. Bullock
Interstitial Lactate in the Peritraumatic Penumbra of Rat Brain	353	(4)
J. Eriskat
M. Stoffel
N. Plesnila
M. Rinecker
A. Baethmann
Attenuation of Secondary Lesion Growth in the Brain After Trauma by Selective Inhibition of the Inducible No-Synthase	357	(2)
M. Stoffel
M. Rinecker
N. Plesnila
J. Eriskat
A. Baethmann
Evidence for Lactate Uptake After Rat Fluid Percussion Brain Injury	359	(6)
T. Chen. Y. Z. Qian
X. Di
J. P. Zhu
R. Bullock
Topical Application of Brain Derived Neurotrophic Factor Influences Upregulation of Constitutive Isoform of Heme Oxygenase in the Spinal Cord Following Trauma An Experimental Study Using Immunohistochemistry in the Rat	365	(6)
H. S. Sharma
J. Westman
T. Gordh
P. Alm
Time Profile of Neuron Specific Enolase Serum Levels After Experimental Brain Injury in Rat	371	(4)
C. Woertgen
R. D. Rothoerl
A. Brawanski
Isoflurane Doubles Plasma Glutamate and Increases Posttraumatic Brain Edema	375	(4)
J. F. Stover
S. N. Kroppenstedt
U. W. Thomale
O. S. Kempski
A. W. Unterberg
Mechanical Injury Alters Volume Activated Ion Channels in Cortical Astrocytes	379	(6)
X. Di
P. B. Goforth
R. Bullock
E. Ellis
L. Satin
Thyroid Hormones in Comatose Patients with Traumatic Brain Injury	385	(8)
V. D. Tenedieva
A. A. Potapov
E. I. Gaitur
V. G. Amcheslavski
L. V. Micrikova
N. D. Tenedieva
V. G. Voronov
S-100b as a Screening Marker of the Severity of Minor Head Trauma (MHT) - a Pilot Study	393	(4)
T. Mussack
P. Biberthaler
E. Wiedemann
K. G. Kanz
A. Englert
C. Gippner-Steppert
M. Jochum
Influences of Secondary Injury Following Traumatic Brain Injury in Developing Versus Adult Rats	397	(4)
S. Thomas
F. Tabibnia
M. U. Schuhmann
T. Brinker
M. Samii
The Role of Decompressive Craniectomy in the Treatment of Uncontrollable Post-Traumatic Intracranial Hypertension	401	(4)
G. P. De Luca
L. Volpin
U. Fornezza
P. Cervellini
M. Zanusso
L. Casentini
D. Curri
M. Piacentino
G. Bozzato
F. Colombo
The Impact of Acute Hyponatraemia on Severe Traumatic Brain Injury in Rats	405	(4)
C. Ke
W. S. Poon
H. K. Ng
N. L. S. Tang
Y. Chan
J. Y. Wang
J. N. K. Hsiang
Validation of a Closed Head Injury Model for use in Long-Term Studies	409	(6)
G. De Mulder
K. Van Rossem
J. Van Reempts
M. Borgers
J. Verlooy
Diffuse Axonal Injury with or Without an Evacuated Intracranial Hematoma in Head Injured Patients. Are They Different Lesions?	415	(4)
S. Lubillo
J. Bolanos
J. A. Cardenosa
F. Robaina
P. Ponce
J. Morera
J. L. Manzano
Increased Adrenomedullin in Cerebrospinal Fluid After Traumatic Brain Injury in Children: A Preliminary Report	419	(4)
C. L. Robertson
N. Minamino
R. A. Ruppel
K. Kangawa
P. D. Adelson
T. Tsuji
S. R. Wisniewski
H. Ohta
K. L. Janesko
P. M. Kochanek
Head Injury: Monitoring	423	(72)
Low Extracellular (ECF) Glucose Affects the Neurochemical Profile in Severe Head-Injured Patients	425	(6)
B. Alessandri
M. Reinert
H. F. Young
R. Bullock
On-Line Monitoring of Substrate Delivery and Brain Metabolism in Head Injury	431	(6)
P. J. A. Hutchinson
P. G. Al-Rawi
M. T. O'Connell
A. K. Gupta
L. B. Maskell
D. B. A. Hutchinson
J. D. Pickard
P. J. Kirkpatrick
Extracellular Glutamate and Asparate in Head Injured Patients	437	(2)
S. P. Gopinath
A. B. Valadka
J. C. Goodman
C. S. Robertson
Substrate Delivery and Ionic Balance Disturbance After Severe Human Head Injury	439	(6)
M. Reinert
B. Hoelper
E. Doppenberg
A. Zauner
R. Bullock
Assessment of the Variation in Cerebrovascular Reactivity in Head Injured Patients	445	(6)
S. A. Jackson
I. Piper
L. Dunn
C. Leffler
M. Daley
Non-Invasive Cerebral Perfusion Pressure (nCPP): Evaluation of the Monitoring Methodology in Head Injured Patients	451	(2)
E. A. Schmidt
M. Czosnyka
B. F. Matta
I. Gooskens
S. Piechnik
J. D. Pickard
A Study of the Effects of Using Different Cerebral Perfusion Pressure (CPP) Thresholds to Quantify CPP ``Secondary Insults'' in Children	453	(4)
S. Jackson
I. R. Piper
A. Wagstaff
M. Souter
Does an Increase in Cerebral Perfusion Pressure Always Mean a Better Oxygenated Brain? A Study in Head-Injured Patients	457	(6)
J. Sahuquillo
S. Amoros
A. Santos
M. A. Poca
H. Panzardo
L. Dominguez
S. Pedraza
Continuous Monitoring of ICP and CPP Following ICH and its Relationship to Clinical, Radiological and Surgical Parameters	463	(4)
H. M. Fernandes
S. Siddique
K. Banister
I. Chambers
T. Wooldridge
B. Gregson
A. D. Mendelow
Neuromuscular Blocking Agents in Neurointensive Care	467	(4)
N. Juul
G. F. Morris
S. B. Marshall
L. F. Marshall
The Role of Nitric Oxide in Reoxygenation Injury of Brain Microvascular Endothelial Cells	471	(4)
T. Nagashima
S. Wu
K. Ikeda
N. Tamaki
The Use of Decompressive Craniectomy for the Management of Severe Head Injuries	475	(4)
U. Meier
F. S. Zeilinger
O. Henzka
Transcranial Doppler Ultrasonography (TCD) in Ventilated Head Injured Patients: Correlation with Stable Xenon-Enhanced CT	479	(4)
S. C. P. Ng
W. S. Poon
M. T. V. Chan
J. M. K. Lam
C. Metreweli
Continuous Assessment of Cerebral Autoregulation - Clinical Verification of the Method in Head Injured Patients	483	(2)
M. Czosnyka
P. Smielewski
S. Piechnik
E. A. Schmidt
H. Seeley
P. Al-Rawi
B. F. Matta
P. J. Kirkpatrick
J. D. Pickard
False Autoregulation (Pseudoautoregulation) in Patients with Severe Head Injury. Its Importance in CPP Management	485	(6)
J. Sahuquillo
S. Amoros
A. Santos
M. A. Poca
H. Valenzuela
M. Baguena
A. Garnacho
Multi-Centre Assessment of the Spiegelberg Compliance Monitor: Preliminary Results	491	(4)
I. Piper
L. Dunn
C. Contant
Y. Yau
I. Whittle
G. Citerio
K. Kiening
W. Schvning
S. Ng
W. Poon
P. Enblad
P. Nilsson
Brain-IT Group
Stroke, Subarachnoid and Intracerebral Haemorrhage	495	(28)
Intracranial Hypertension Influences the Resolution of Vasogenic Brain Edema Following Intracerebral Hemorrhage	497	(4)
M. Holtmannspotter
A. Schoch
A. Baethmann
H.-J. Reulen
E. Uhl
Induction of Colligin may Attenuate Brain Edema Following Intracerebral Hemorrhage	501	(6)
G. Xi
Y. Hua
R. F. Keep
J. T. Hoff
Oxyhemoglobin Produces Necrosis in Cultured Smooth Muscle Cells	507	(4)
K. Ogihara
A. Y. Zubkov
A. D. Parent
J. H. Zhang
Thrombin Preconditioning, Heat Shock Proteins and Thrombin-Induced Brain Edema	511	(6)
G. Xi
R. F. Keep
Y. Hua
J. T. Hoff
Changes in Cerebral Blood Flow as Measured by HMPAO SPECT in Patients Following Spontaneous Intracerebral Haemorrhage	517	(4)
M. S. Siddique
H. M. Fernandes
N. U. Arene
T. D. Wooldridge
J. D. Fenwick
A. D. Mendelow
Surgical Trial in Intracerebral Haemorrhage (S.T.I.C.H)	521	(2)
A. D. Mendelow on behalf of the investigators
Thermal Effects	523	(34)
Postischemic Hypothermia Attenuates Apoptotic Cell Death in Transient Focal Ischemia in Rats	525	(4)
J. Inamasu
S. Suga
S. Sato
T. Horiguchi
K. Akaji
K. Mayanagi
T. Kawase
Effects of Hypothermia on Intracranial Hemodynamics and Ischemic Brain Damage-Studies in the Rat Acute Subdural Hematoma Model	529	(6)
N. Kawai
T. Nakamura
M. Okauchi
S. Nagao
Blockade of Histamine H2 Receptors Attenuate Blood-Brain Barrier Permeability, Cerebral Blood Flow Disturbances, Edema Formation and Cell Reactions Following Hyperthermic Brain Injury in the Rat	535	(6)
R. Patnaik
S. Mohanty
H. S. Sharma
Selective Alteration of Calcitonin Gene Related Peptide in Hyperthermic Brain Injury. An Experimental Study in the Rat Brain Using Immunohistochemistry	541	(6)
H. S. Sharma
J. Westman
F. Nyberg
Protective Effect of Mild Hypothermia on Symptomatic Vasospasm: A Preliminary Report	547	(4)
S. Nagao
K. Irie
N. Kawai
K. Kunishio
T. Ogawa
T. Nakamura
M. Okauchi
Influence of Hypothermia on Cell Volume and Cytotoxic Swelling of Glial Cells in Vitro	551	(6)
E. Mueller
J. Wietzorrek
F. Ringel
S. Guretzki
A. Baethmann
N. Plesnila
Hydrocephalus	557	(10)
Clinical Experiences with the Dual-Switch Valve in Patients with Normal Pressure Hydrocephalus	559	(4)
F. S. Zeilinger
T. Reyer
U. Meier
D. Kintzel
Endoscopic Ventriculostomy Versus Shunt Operation in Normal Pressure Hydrocephalus: Diagnostics and Indication	563	(4)
U. Meier
F. S. Zeilinger
B. Schonherr
Author Index	567	(4)
Index of Keywords	571