Brain Norepinephrine

by Ordway, Gregory A., Ph.D.; Schwartz, Michael A., M.D.; Frazer, Alan

• ISBN13: 9781107407411
• ISBN10: 1107407419
• Edition: Reprint
• Format: Paperback
• Copyright: 2012-09-19
• Publisher: Cambridge Univ Pr

Summary

This book was first published in 2007. Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

Table of Contents

Introduction: Revision of an Old Transmitter

The Neurobiology of Norepinephrine

Neuroanatomical and chemical organization of the locus coeruleus

Interactions of norepinephrine with other neurotransmitter systems: anatomical basis and pharmacology

Receptors for norepinephrine and signal transduction pathways

Regulation of gene transcription in the central nervous system by norepinephrine

The norepinephrine transporter and regulation of synaptic transmission

Norepinephrine and Behavior

Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep wake cycle

Locus coeruleus and regulation of behavioral flexibility and attention: clinical implications

Norepinephrine and long-term memory function

Norepinephrine and stress

The Biology of Norepinephrine in CNS Pathology

Animal models of psychopathology: focus on norepinephrine

Neuropathology of central norepinephrine in psychiatric disorders: postmortem research

Norepinephrine in mood disorders

Noradrenergic pathology and pain

Norepinephrine in cognitive disorders

Norepinephrine in neurological disorders

Genetics of noradrenergic neurobiology

Psychopharmacology of Norepinephrine

Actions of antidepressant and other drugs on norepinephrine systems

The clinical role of norepinephrine antidepressants in depression and anxiety disorders

Norepinephrine in attention deficit hyperactivity disorder

Psychopharmacology of norepinephrine in eating disorders

Role of norepinephrine in substance abuse

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