Brain-cancer Associated Tumor Marker Genes Expression Pattern in Humans

by Said, Harun M.

• ISBN13: 9781617280115
• ISBN10: 1617280119
• Edition: 1st
• Format: Paperback
• Copyright: 2011-03-01
• Publisher: NOVA SCIENCE PUBLISHERS INC

Summary

Hypoxia is an important phenomenon possessing a significant correlation with tumour progression, treatment results and the overall disease prognosis. Tumour oxygenation state leads to a series of genomic changes, enabling tumour cells survival or overcoming the oxygen deficient environment conditions. Tumour tissue growth requires a sufficient oxygen and nutrients supply. Tumour cell responses to hypoxic stress include adaptive proteomic changes allowing the cells to overcome nutritive deprivation or to escape their hostile environment by proliferation, invasion, or metastatic spread. Tumour cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides. This book will supply information regarding this pattern in brain cancer.

Table of Contents

Introduction & Background

Biochemistry of Human Brain Tumor Cells: Metabolism in Human Brain Tumor Cells

Potential Role of Glycolytic Inhibitors in Human Brain Cancer Treatment

Potential Role of Chemical Inhibitors in Human Brain Cancer Treatment

Glucose Metabolism in Human Cancer Cells

Metabolic Control Analysis in Human Brain Tumors

Glycolytic Regulation in Human Brain Tumors Involvement of Glucose Availability in Hypoxia Induced Gene Expression

Hypoxia Induced HiF-1 Gene Regulation in Human Glioblastoma

Hypoxia Induced Ca9 Expression in Human Brain Tumor Cells

Role of VEGF in Human Brain Tumors under Hypoxic Conditions

Hypoxia Induced OPN Expression in Human Brain Tumors Cells

Hypoxia Induced Epo Expression in Human Brain Tumors Cells

Hypoxia Induced NDRG1 Expression in Human Brain Tumor cells

Regulation via other Hypoxia Gene Regulators

Conclusions

Index

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