Breast Cancer Management and Molecular Medicine

by Piccart, Martine J.; Wood, William C.; Hung, Mien-Chie; Solin, Lawrence J.; Cardoso, Fatima

• ISBN13: 9783540282655
• ISBN10: 3540282653
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-03-15
• Publisher: Springer Verlag

Summary

Molecular-based medicine is taking center stage due to the increasing knowledge of breast cancer molecular biology. Treatment tailoring is no longer a dream for the future, but the main goal of current research.This book provides an overview of the most recent techniques, agents and approaches for breast cancer that contribute to the individualization of treatment. Current biomedical research focuses on facilitating the transfer of molecular biology knowledge into the clinical management of patients, leading to increased survival as well as improved quality of life. Particular attention is given in this book to organ-specific tailored approaches, specific populations, patients' preferences and rehabilitation. Also discussed in depth are the respective roles of pharmacotherapeutics modelling, functional imaging, molecular staging, genomics and proteomics and their impact on the "re-classification" of breast cancer, as well as the clinical applications of basic science. The crucial issue of how to optimally integrate biological markers, new technologies and new diagnostic and therapeutic approaches into clinical trials and clinical practice is addressed.Combining the contributions from authors who are well known experts in these fields with editorial comments, this book provides an overview of the latest achievements in breast cancer and their use in clinical practice.

Table of Contents

Role of modeling in pharmacotherapeutics	p. 3
PET and nuclear medicine imaging of the breast	p. 31
Functional radiologic imaging in breast cancer	p. 43
Prevention of breast cancer	p. 63
DCIS : pathology and molecular markers	p. 99
Ductal carcinoma in situ : a modern approach to patient management	p. 125
Ductal carcinoma in situ : systemic treatment	p. 137
Tailored surgery for early breast cancer : surgical techniques	p. 161
Tailored surgery for early breast cancer : biological aspects	p. 183
Tailored surgery for early breast cancer : the very young woman	p. 199
Tailored surgery for older women with breast cancer	p. 215
Tailored radiotherapy for breast cancer stages I and II : technical aspects	p. 235
Breast cancer management in the era of molecular medicine : tailored radiotherapy - clinical and biological aspects	p. 257
Early breast cancer (stage I and II) : tailored radiotherapy for very young women	p. 279
The elderly and breast cancer radiotherapy	p. 291
Early breast cancer (stage I and stage II) : tailored systemic therapy for endocrine-resistant breast cancer	p. 309
Early breast cancer (stage I and stage II) : tailored systemic therapy for endocrine-responsive breast cancer	p. 327
Tailored therapy for breast cancer in very young women	p. 349
Tailored systemic therapy for the elderly woman	p. 375
Locoregional therapy following neoadjuvant chemotherapy : an evolving paradigm of treatment individualization	p. 401
Medical therapy of locally advanced breast cancer	p. 427
Metastatic breast cancer : tailored endocrine therapy for premenopausal women	p. 451
Metastatic breast cancer : tailored endocrine therapy for postmenopausal women	p. 465
Metastatic breast cancer : tailored chemotherapy for the elderly woman	p. 479
Treatment of brain metastases from breast cancer	p. 505
Surgical management of breast cancer liver metastases	p. 525
Individualization of bisphosphonate therapy	p. 545
Breast cancer metastases to the eye	p. 565
Organ-specific approaches : pain management	p. 569
Genomic and molecular classification of breast cancer	p. 595
Applications of proteomics to clinical questions in breast cancer	p. 623
Targeting the HER family of receptors in the treatment of advanced breast cancer	p. 643
Biological therapies for metastatic breast cancer : antiangiogenesis	p. 671
Breast cancer gene therapy	p. 705
Innovative rational-derived, target-based and cytotoxic therapies for breast cancer and other malignancies	p. 741
Mechanisms of breast cancer resistance to chemotherapy	p. 783
Mechanisms of resistance to hormone therapy	p. 805
Novel signaling pathways in breast cancer	p. 823
Mechanisms of apoptosis resistance in breast cancer	p. 841
Breast cancer and pregnancy	p. 863
Hormone replacement therapy after breast cancer	p. 879
Male breast cancer	p. 903
Patients' preferences : what makes treatments worthwhile?	p. 925
Breast cancer : the impact of depression and its treatment	p. 945
Molecular profiling in breast cancer	p. 977
Clinical trials in the era of treatment tailoring	p. 1007
Table of Contents provided by Blackwell. All Rights Reserved.